scholarly journals Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 798
Author(s):  
Xu Yang ◽  
Zhiwei Wang ◽  
Jing Sun
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Uv Irradiation ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Morphological Transitions ◽  
Poly Ethylene ◽  
Copolymer Poly

Photoresponsive polymers have attracted increasing interest for a variety of applications. Here, we report a family of photoresponsive polypeptoid-based copolymer poly(ethylene glycol)-b-poly(N-(S-(o-nitrobenzyl)-thioethyl) glycine)-co-poly(N-(2-phenylethyl) glycine) (PEG-b-PNSN-co-PNPE) synthesized by the controlled ring-opening polymerization (ROP) technique. The key feature of the design is to incorporate both o-nitrobenzyl group moiety to offer the photoresponsive property and phenethyl residues to tune the structural and amphiphilic property of the system. We demonstrate that the cleavage degree of the o-nitrobenzyl group can reach to 100% upon UV-irradiation. With delicate design, a photoresponsive vesicle-to-sphere transition has been observed that facilitates the release of the encapsulants. This work provides a facile approach to prepare a type of photoresponsive polymers with tunable properties for drug delivery.

Synthesis of Poly(ethylene glycol)-Block-Poly(lactide) via Sequential Ring-Opening Polymerization Technique for Preparing Micellar Carriers

2015 ◽  
Vol 749 ◽  
pp. 433-436
Author(s):  
Chih Kuang Chen ◽  
Wen Jen Lin ◽  
Guan You Chen ◽  
Yu Te Lin ◽  
Rong Siou Jhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Chain Length ◽  
Self Assembly ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Material Chemistry ◽  
Poly Ethylene

With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer drug delivery. In this study, a newly developed polymerization technique termed as “sequential ring-opening polymerization (SROP)“ was used to synthesize poly (ethylene glycol)-block-polylactide-block-polylactide (PEG-PLA-PLAs). Utilizing the features of SROP, well-controlled chain length of two different PLA blocks by using PEG as initiator can be achieved. Two types of PEG-PLA-PLAs, PEG-PLA11-PLA11 and PEG-PLA18-PLA18, were successfully synthesized and characterized. Having amphiphilic properties, PEG-PLA-PLAs were used to form micelles through self-assembly. The effects of PLA length on the resultant micelles were thoroughly investigated.

Synthesis and sequence-controlled self-assembly of amphiphilic triblock copolymers based on functional poly(ethylene glycol)

2017 ◽  
Vol 8 (45) ◽  
pp. 6964-6971 ◽  
Author(s):  
Yanxin Qi ◽  
Bin Li ◽  
Yupeng Wang ◽  
Yubin Huang
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Ring Opening ◽  
Glycidyl Ether ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Amphiphilic Triblock Copolymer ◽  
Allyl Glycidyl Ether ◽  
Poly Ethylene ◽  
Copolymer Poly

Given the increasing prosperity of multifunctional poly(ethylene glycol) (mf-PEG), an amphiphilic triblock copolymer, poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly(allyl glycidyl ether) (mPEG-PCL-PAGE), was synthesized by a combination of living ring-opening polymerization (ROP) and click chemistry.

Controlled Release of Proteins from Their Poly(Ethylene Glycol) Conjugates:  Drug Delivery Systems Employing 1,6-Elimination

2003 ◽  
Vol 14 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Richard B. Greenwald ◽  
Karen Yang ◽  
Hong Zhao ◽  
Charles D. Conover ◽  
Stanford Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme

2020 ◽  
Vol 2 (10) ◽  
pp. 4498-4509
Author(s):  
Majed Alghamdi ◽  
Filippo Chierchini ◽  
Dimitri Eigel ◽  
Christian Taplan ◽  
Thomas Miles ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Glioblastoma Multiforme ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Soft and flexible poly(ethylene glycol)-based nanotubes load doxorubicin for controlled release to glioblastoma multiforme.

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