Formation of Ionomer Microparticles via Polyelectrolyte Complexation

2021 ◽  
Author(s):  
Xiaozheng Duan ◽  
An-Chang Shi ◽  
Lijia An
Keyword(s):  
Polyelectrolyte Complexation

scholarly journals Production and Characterization of Chitosan–Polyanion Nanoparticles by Polyelectrolyte Complexation Assisted by High-Intensity Sonication for the Modified Release of Methotrexate

2020 ◽  
Vol 13 (1) ◽  
pp. 11 ◽  
Author(s):  
Yhors Ciro ◽  
John Rojas ◽  
Maria Alhajj ◽  
Gustavo Carabali ◽  
Constain Salamanca
Keyword(s):  
Zeta Potential ◽  
Maleic Acid ◽  
High Intensity ◽  
Physical Stability ◽  
Release Mechanism ◽  
Diffusion Controlled ◽  
Polyelectrolyte Complexation ◽  
Anticancer Treatment ◽  
Particle Parameters

A promising strategy to improve the effectivity of anticancer treatment and decrease its side effects is to modulate drug release by using nanoparticulates (NPs) as carriers. In this study, methotrexate-loaded chitosan–polyanion nanoparticles were produced by polyelectrolyte complexation assisted by high-intensity sonication, using several anionic polymers, such as the sodium and potassium salts of poly(maleic acid-alt-ethylene) and poly(maleic acid-alt-octadecene), here named PAM-2 and PAM-18, respectively. Such NPs were analyzed and characterized according to particle size, polydispersity index, zeta potential and encapsulation efficiency. Likewise, their physical stability was tested at 4 °C and 40 °C in order to evaluate any change in the previously mentioned particle parameters. The in vitro methotrexate release was assessed at a pH of 7.4, which simulated physiological conditions, and the data were fitted to the heuristic models of order one, Higuchi, Peppas–Sahlin and Korsmeyer–Peppas. The results revealed that most of the MTX-chitosan–polyanion NPs have positive zeta potential values, sizes <280 nm and monodisperse populations, except for the NPs formed with PAM-18 polyanions. Further, the NPs showed adequate physical stability, preventing NP–NP aggregation. Likewise, these carriers modified the MTX release by an anomalous mechanism, where the NPs formed with PAM-2 polymer led to a release mechanism controlled by diffusion and relaxation, whereas the NPs formed with PAM-18 led to a mainly diffusion-controlled release mechanism.

Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell-core microparticles

2015 ◽  
Vol 133 (6) ◽  
pp. n/a-n/a ◽  
Author(s):  
Annalisa Dalmoro ◽  
Alexander Y. Sitenkov ◽  
Gaetano Lamberti ◽  
Anna Angela Barba ◽  
Rouslan I. Moustafine
Keyword(s):  
Ultrasonic Atomization ◽  
Polyelectrolyte Complexation

Stabilisation of fatty acid mono- and multilayers by simultaneous polyelectrolyte complexation and salt formation with cadmium ions

1997 ◽  
Vol 295 (1-2) ◽  
pp. 246-249 ◽  
Author(s):  
F. Feñacorada ◽  
J. Reiche ◽  
T. Zetzsche ◽  
R. Dietel ◽  
L. Brehmer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Salt Formation ◽  
Cadmium Ions ◽  
Polyelectrolyte Complexation

Hydrophilic drug encapsulation in shell-core microcarriers by two stage polyelectrolyte complexation method

2017 ◽  
Vol 518 (1-2) ◽  
pp. 50-58 ◽  
Author(s):  
Annalisa Dalmoro ◽  
Alexander Y. Sitenkov ◽  
Sara Cascone ◽  
Gaetano Lamberti ◽  
Anna Angela Barba ◽  
...  
Keyword(s):  
Two Stage ◽  
Drug Encapsulation ◽  
Hydrophilic Drug ◽  
Polyelectrolyte Complexation

Nanocarrier for Oral Peptide Delivery Produced by Polyelectrolyte Complexation in Nanoconfinement

2015 ◽  
Vol 16 (8) ◽  
pp. 2282-2287 ◽  
Author(s):  
Wei He ◽  
Maria Parowatkin ◽  
Volker Mailänder ◽  
Marion Flechtner-Mors ◽  
Robert Graf ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Oral Peptide Delivery ◽  
Polyelectrolyte Complexation

scholarly journals Chitosan–Carboxymethylcellulose-Based Polyelectrolyte Complexation and Microcapsule Shell Formulation

2018 ◽  
Vol 19 (9) ◽  
pp. 2521 ◽  
Author(s):  
Jagadish Roy ◽  
Ada Ferri ◽  
Stéphane Giraud ◽  
Guan Jinping ◽  
Fabien Salaün
Keyword(s):  
Process Conditions ◽  
Mass Ratio ◽  
Oil Emulsion ◽  
Electrostatic Deposition ◽  
Emulsion Droplets ◽  
Core Content ◽  
Paraffin Oil ◽  
Polyelectrolyte Complexation ◽  
Carboxymethyl Cellulose Sodium ◽  
Shell Formulation

Chitosan (CH)–carboxymethyl cellulose sodium salt (NaCMC) microcapsules containing paraffin oil were synthesized by complex formation, and crosslinked with glutaraldehyde (GTA). The electrostatic deposition of NaCMC onto the CH-coated paraffin oil emulsion droplets was demonstrated by zeta potential and optical microscopy. The optimal process conditions were identified in terms of pH of the aqueous solution (5.5) and CH/NaCMC mass ratio (1:1). Encapsulation of paraffin oil and microcapsule morphology were analyzed by ATR-FTIR and SEM, respectively. The effect of GTA crosslinking on paraffin oil latent heat was investigated by DSC and combined with the values of encapsulation efficiency and core content, supporting the compact shell formation.

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