Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell-core microparticles

Annalisa Dalmoro; Alexander Y. Sitenkov; Gaetano Lamberti; Anna Angela Barba; Rouslan I. Moustafine

doi:10.1002/app.42976

Ultrasonic atomization and subsequent desolvation for monoclonal antibody (mAb) to the glycoprotein (GP) IIIa receptor into drug eluting stent

Journal of Microencapsulation ◽

10.1080/02652040903046798 ◽

2009 ◽

pp. 090630073114053

Author(s):

G. X. Wang ◽

L. L. Luo ◽

T. Y. Yin ◽

Y. Li ◽

T. Jiang ◽

...

Keyword(s):

Monoclonal Antibody ◽

Drug Eluting Stent ◽

Ultrasonic Atomization ◽

Drug Eluting

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INFLUENCE OF AIR-DRAFT ON FABRICATION OF POLYURETHANE THIN FILMS VIA ULTRASONIC ATOMIZATION

Atomization and Sprays ◽

10.1615/atomizspr.2012004070 ◽

2012 ◽

Vol 22 (1) ◽

pp. 23-35 ◽

Cited By ~ 1

Author(s):

Anandh Balakrishnan ◽

Mrinal C. Saha

Keyword(s):

Thin Films ◽

Ultrasonic Atomization

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CFD simulation of ultrasonic atomization pyrolysis reactor: the influence of droplet behaviors and solvent evaporation

International Journal of Chemical Reactor Engineering ◽

10.1515/ijcre-2020-0229 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Jian Wang ◽

Jichuan Wu ◽

Shouqi Yuan ◽

Wei-Cheng Yan

Keyword(s):

Flow Pattern ◽

Size Distribution ◽

Droplet Size ◽

Cfd Simulation ◽

Collection Efficiency ◽

Great Influence ◽

Droplet Size Distribution ◽

Solvent Evaporation ◽

Droplet Collision ◽

Ultrasonic Atomization

Abstract Previous work showed that particle behaviors in ultrasonic atomization pyrolysis (UAP) reactor have a great influence on the transport and collection of particles. In this study, the effects of droplet behaviors (i.e. droplet collision and breakage) and solvent evaporation on the droplet size, flow field and collection efficiency during the preparation of ZnO particles by UAP were investigated. The collision, breakage and solvent evaporation conditions which affect the droplet size distribution and flow pattern were considered in CFD simulation based on Eulerian-Lagrangian method. The results showed that droplet collision and breakage would increase the droplet size, broaden the droplet size distribution and hinder the transport of droplets. Solvent evaporation obviously changed the flow pattern of droplets. In addition, both droplet behaviors and solvent evaporation reduced the collection efficiency. This study could provide detail information for better understanding the effect of droplet behaviors and solvent evaporation on the particle production process via UAP reactor.

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Production and Characterization of Chitosan–Polyanion Nanoparticles by Polyelectrolyte Complexation Assisted by High-Intensity Sonication for the Modified Release of Methotrexate

Pharmaceuticals ◽

10.3390/ph13010011 ◽

2020 ◽

Vol 13 (1) ◽

pp. 11 ◽

Cited By ~ 3

Author(s):

Yhors Ciro ◽

John Rojas ◽

Maria Alhajj ◽

Gustavo Carabali ◽

Constain Salamanca

Keyword(s):

Zeta Potential ◽

Maleic Acid ◽

High Intensity ◽

Physical Stability ◽

Release Mechanism ◽

Diffusion Controlled ◽

Polyelectrolyte Complexation ◽

Anticancer Treatment ◽

Particle Parameters

A promising strategy to improve the effectivity of anticancer treatment and decrease its side effects is to modulate drug release by using nanoparticulates (NPs) as carriers. In this study, methotrexate-loaded chitosan–polyanion nanoparticles were produced by polyelectrolyte complexation assisted by high-intensity sonication, using several anionic polymers, such as the sodium and potassium salts of poly(maleic acid-alt-ethylene) and poly(maleic acid-alt-octadecene), here named PAM-2 and PAM-18, respectively. Such NPs were analyzed and characterized according to particle size, polydispersity index, zeta potential and encapsulation efficiency. Likewise, their physical stability was tested at 4 °C and 40 °C in order to evaluate any change in the previously mentioned particle parameters. The in vitro methotrexate release was assessed at a pH of 7.4, which simulated physiological conditions, and the data were fitted to the heuristic models of order one, Higuchi, Peppas–Sahlin and Korsmeyer–Peppas. The results revealed that most of the MTX-chitosan–polyanion NPs have positive zeta potential values, sizes <280 nm and monodisperse populations, except for the NPs formed with PAM-18 polyanions. Further, the NPs showed adequate physical stability, preventing NP–NP aggregation. Likewise, these carriers modified the MTX release by an anomalous mechanism, where the NPs formed with PAM-2 polymer led to a release mechanism controlled by diffusion and relaxation, whereas the NPs formed with PAM-18 led to a mainly diffusion-controlled release mechanism.

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Determination of cost-efficient cooling power range for improving the performance of internally cooled ultrasonic atomization liquid desiccant dehumidifiers

Indoor and Built Environment ◽

10.1177/1420326x20913325 ◽

2020 ◽

Vol 29 (9) ◽

pp. 1260-1276

Author(s):

Zili Yang ◽

Lu-An Chen ◽

Ruiyang Tao ◽

Ke Zhong

Keyword(s):

Power Efficiency ◽

Removal Rate ◽

Operating Conditions ◽

Cooling Power ◽

Internal Cooling ◽

Liquid Desiccant ◽

Improvement Rate ◽

Ultrasonic Atomization ◽

Internally Cooled ◽

Cost Efficient

Liquid desiccant dehumidifiers (LDDs) can be improved by adding internal cooling. However, the addition of excessive cooling power may deteriorate the system‘s cost-efficiency, whereas the addition of insufficient cooling power leads to negligible performance improvements. The objective of this study is to determine the suitable cost-efficient cooling power range for improving the performance of internally cooled LDDs (IC-LDDs). A novel method and a set of criteria related to the moisture removal rate, cooling-power efficiency ( ηc) and coefficient of dehumidification performance from cooling power ( DCOPcooling) were proposed to determine cost-efficient cooling power. The internally cooled ultrasonic atomization liquid desiccant system (IC-UADS), together with a well-validated model based on the conservation laws of mass and energy and the sensible heat balance, was adopted to demonstrate the analysis. The results showed that, although the dehumidification performance improves with increasing cooling power, the improvement rate decreases, while ηcand DCOPcoolingdecline quickly (by 87.9%). For cost-efficient improvement, the necessary power proportion of internal cooling to the system‘s target dehumidification capacity tends to be stable, which was about 29% for the IC-UADS, and independent of the operating conditions. The results may help to determine the reasonable cooling power range for cost-efficient improvement of IC-LDDs.

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