Phosphorene as a Template Material for Physisorption of DNA/RNA Nucleobases and Resembling of Base Pairs: A Cluster DFT Study and Comparisons with Graphene

2018 ◽  
Vol 122 (9) ◽  
pp. 4870-4880 ◽  
Author(s):  
Diego Cortés-Arriagada
Keyword(s):  
Dft Study ◽  
Base Pairs ◽  
Template Material

Intercalation of Daunomycin into Stacked DNA Base Pairs. DFT Study of an Anticancer Drug

2008 ◽  
Vol 26 (1) ◽  
pp. 115-129 ◽  
Author(s):  
Giampaolo Barone ◽  
Célia Fonseca Guerra ◽  
Noemi Gambino ◽  
Arturo Silvestri ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Dft Study ◽  
Base Pairs ◽  
Dna Base ◽  
Dna Base Pairs

scholarly journals DFT study on the attacking mechanisms of H and OH radicals to G-C and A-T base pairs in water

2016 ◽  
Author(s):  
N. Okutsu ◽  
K. Shimamura ◽  
E. Shimizu ◽  
S. Shulga ◽  
V. I. Danilov ◽  
...  
Keyword(s):  
Dft Study ◽  
Oh Radicals ◽  
Base Pairs

scholarly journals On the Dimers Stability of Allicin and Its Derivatives Interacting with AT, GC, and DNA Bridge: DFT Study

2017 ◽  
Vol 2017 ◽  
pp. 1-11
Author(s):  
Mindaugas Macernis
Keyword(s):  
Direct Effect ◽  
Base Pair ◽  
Dft Calculation ◽  
Health Benefits ◽  
Dft Study ◽  
Base Pairs ◽  
Potential Health ◽  
Dna Base ◽  
Dna Base Pairs ◽  
Calculation Results

Allicin and its derivatives are physiologically active molecules with many potential health benefits. It is not clear if they have a direct effect on DNA or protein. In order to elucidate the allicin and its derivatives’ effect on DNA base pairs, we investigated various complexes of base pair and its bridge with an allicin and its derivatives. The investigated allicin derivatives were (E)-Ajoene, (Z)-Ajoene, Amz121, and Bmz73 radicals. The DFT calculation results revealed that the investigated molecules would favor binding to bridge of the base pairs instead of directly affecting the base pairs. The Bmz73 radical could break DNA by change bonding in it because the Bmz73 radical significantly affected the P-O bond of the bridge of base pair.

scholarly journals Role of the backbone of nucleic acids in the stability of Hg2+-mediated canonical base pairs and thymine–thymine mispair: a DFT study

RSC Advances ◽  
2020 ◽  
Vol 10 (67) ◽  
pp. 40969-40982
Author(s):  
Surjit Bhai ◽  
Bishwajit Ganguly
Keyword(s):  
Nucleic Acids ◽  
Dft Study ◽  
Base Pairs ◽  
Canonical Base ◽  
The Stability

Hg2+-mediated PNA–PNA mispair duplex (PTTTTP) is more energetically favoured compared to DNA–DNA mispair duplex (DTTTTD).

Detection of the Glanzmann's Thrombasthenia Mutations in Arab and Iraqi-Jewish Patients by Polymerase Chain Reaction and Restriction Analysis of Blood or Urine Samples

1991 ◽  
Vol 66 (04) ◽  
pp. 500-504 ◽  
Author(s):  
H Peretz ◽  
U Seligsohn ◽  
E Zwang ◽  
B S Coller ◽  
P J Newman
Keyword(s):  
Polymerase Chain Reaction ◽  
Base Pair ◽  
Restriction Analysis ◽  
Urine Samples ◽  
Chain Reaction ◽  
Base Pairs ◽  
Glanzmann’S Thrombasthenia ◽  
Glanzmann's Thrombasthenia ◽  
Base Pair Deletion ◽  
Polymerase Chain

SummarySevere Glanzmann's thrombasthenia is relatively frequent in Iraqi-Jews and Arabs residing in Israel. We have recently described the mutations responsible for the disease in Iraqi-Jews – an 11 base pair deletion in exon 12 of the glycoprotein IIIa gene, and in Arabs – a 13 base pair deletion at the AG acceptor splice site of exon 4 on the glycoprotein IIb gene. In this communication we show that the Iraqi-Jewish mutation can be identified directly by polymerase chain reaction and gel electrophoresis. With specially designed oligonucleotide primers encompassing the mutation site, an 80 base pair segment amplified in healthy controls was clearly distinguished from the 69 base pair segment produced in patients. Patients from 11 unrelated Iraqi-Jewish families had the same mutation. The Arab mutation was identified by first amplifying a DNA segment consisting of 312 base pairs in controls and of 299 base pairs in patients, and then digestion by a restriction enzyme Stu-1, which recognizes a site that is absent in the mutant gene. In controls the 312 bp segment was digested into 235 and 77 bp fragments, while in patients there was no change in the size of the amplified 299 bp segment. The mutation was found in patients from 3 out of 5 unrelated Arab families. Both Iraqi-Jewish and Arab mutations were detectable in DNA extracted from blood and urine samples. The described simple methods of identifying the mutations should be useful for detection of the numerous potential carriers among the affected kindreds and for prenatal diagnosis using DNA extracted from chorionic villi samples.

DFT study of the effect of hidrocarbonated chains on the electronic properties of some oligothiophene derivatives

2009 ◽  
Author(s):  
Manuel Fernández-Gómez ◽  
Amparo Navarro ◽  
MªPaz Fernández-Liencres ◽  
Mónica Moral ◽  
José Manuel Granadino-Roldán ◽  
...  
Keyword(s):  
Electronic Properties ◽  
Dft Study
Sign in / Sign up

Export Citation Format

Share Document