Complementary Effects of Host Defense Peptides Piscidin 1 and Piscidin 3 on DNA and Lipid Membranes: Biophysical Insights into Contrasting Biological Activities

2015 ◽  
Vol 119 (49) ◽  
pp. 15235-15246 ◽  
Author(s):  
Robert M. Hayden ◽  
Gina K. Goldberg ◽  
Bryan M. Ferguson ◽  
Mason W. Schoeneck ◽  
M. Daben J. Libardo ◽  
...  
Keyword(s):  
Host Defense ◽  
Lipid Membranes ◽  
Biological Activities ◽  
Host Defense Peptides ◽  
Defense Peptides ◽  
Piscidin 3

Cryptic Host Defense Peptides: Multifaceted Activity and Prospects for Medicinal Chemistry

2020 ◽  
Vol 20 (14) ◽  
pp. 1274-1290
Author(s):  
Bruna de Oliveira Costa ◽  
Octávio Luiz Franco
Keyword(s):  
Host Defense ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Proteolytic Processing ◽  
Biologically Active ◽  
Host Defense Peptides ◽  
Clinical Phase ◽  
Evolutionarily Conserved ◽  
Defense Peptides ◽  
Endogenous Precursor

Host defense peptides (HDPs) comprise a heterogeneous group of evolutionarily conserved and biologically active small molecules that are produced by different organisms. HDPs are widely researched because they often have multiple biological activities, for example antimicrobial, immunomodulatory and anticancer activity. In this context, in this review we focus on cryptic HDPs, molecules derived specifically from proteolytic processing of endogenous precursor proteins. Here, we explore the biological activity of such molecules and we further discuss the development of optimized sequences based on these natural cryptic HDPs. In addition, we present clinical-phase studies of cryptic HDPs (natural or optimized), and point out the possible applicability of these molecules in medicinal chemistry.

scholarly journals Molecular and Biological Properties of Snakins: The Foremost Cysteine-Rich Plant Host Defense Peptides

2020 ◽  
Vol 6 (4) ◽  
pp. 220
Author(s):  
Tao Su ◽  
Mei Han ◽  
Dan Cao ◽  
Mingyue Xu
Keyword(s):  
Host Defense ◽  
Plant Pathogens ◽  
Biological Activities ◽  
Expression Patterns ◽  
Family Members ◽  
Biological Properties ◽  
Plant Host ◽  
Host Defense Peptides ◽  
Wide Range ◽  
Defense Peptides

Plant host defense peptides (HDPs), also known as antimicrobial peptides (AMPs), are regarded as one of the most prevalent barriers elaborated by plants to combat various infective agents. Among the multiple classes of HDPs, the Snakin class attracts special concern, as they carry 12 cysteine residues, being the foremost cysteine-rich peptides of the plant HDPs. Also, their cysteines are present at very highly conserved positions and arranged in an extremely similar way among different members. Like other plant HDPs, Snakins have been shown to exhibit strong antifungal and antibacterial activity against a wide range of plant pathogens. Moreover, they display diversified biological activities in many aspects of plant growth and the development process. This review is devoted to present the general characters of the Snakin class of plant HDPs, as well as the individual features of different Snakin family members. Specifically, the sequence properties, spatial structures, distributions, expression patterns and biological activities of Snakins are described. In addition, further detailed classification of the Snakin family members, along with their possible mode of action and potential applications in the field of agronomy and pathology are discussed.

scholarly journals Impact of Metallation and Oxidized Lipids on the Structure and Membrane Disruptive Effects of Host Defense Peptides Piscidin 1 and Piscidin 3

2018 ◽  
Vol 114 (3) ◽  
pp. 453a-454a
Author(s):  
Myriam Cotten ◽  
Ella Mihailescu ◽  
Anna De Angelis ◽  
Ratan Rai ◽  
Dana Moore ◽  
...  
Keyword(s):  
Host Defense ◽  
Oxidized Lipids ◽  
Host Defense Peptides ◽  
Defense Peptides ◽  
Piscidin 3

Geographically Distinct Expression Profile of Host Defense Peptides in the Skin of the Chinese Odorous Frog, Odorrana margaretae

2014 ◽  
Vol 4 (4) ◽  
pp. 288-297
Author(s):  
LING Guiying ◽  
LI Li ◽  
GAO Jiuxiang ◽  
YU Haining ◽  
WANG Yipeng ◽  
...  
Keyword(s):  
Host Defense ◽  
Expression Profile ◽  
Host Defense Peptides ◽  
Defense Peptides

Human Host Defense Peptides - Role in Maintaining Human Homeostasis and Pathological Processes

2017 ◽  
Vol 24 (7) ◽  
pp. 654-672 ◽  
Author(s):  
Malgorzata Anna Dawgul ◽  
Katarzyna E. Greber ◽  
Wieslaw Sawicki ◽  
Wojciech Kamysz
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Human Host ◽  
Defense Peptides

scholarly journals Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in Streptococcus mitis-oralis

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 404
Author(s):  
Michael R. Yeaman ◽  
Liana C. Chan ◽  
Nagendra N. Mishra ◽  
Arnold S. Bayer
Keyword(s):  
Flow Cytometry ◽  
Host Defense ◽  
Durable Resistance ◽  
Cross Resistance ◽  
Streptococcus Mitis ◽  
Host Defense Peptides ◽  
Strain Pair ◽  
Defense Peptides

Streptococcus mitis-oralis (S. mitis-oralis) infections are increasingly prevalent in specific populations, including neutropenic cancer and endocarditis patients. S. mitis-oralis strains have a propensity to evolve rapid, high-level and durable resistance to daptomycin (DAP-R) in vitro and in vivo, although the mechanism(s) involved remain incompletely defined. We examined mechanisms of DAP-R versus cross-resistance to cationic host defense peptides (HDPs), using an isogenic S. mitis-oralis strain-pair: (i) DAP-susceptible (DAP-S) parental 351-WT (DAP MIC = 0.5 µg/mL), and its (ii) DAP-R variant 351-D10 (DAP MIC > 256 µg/mL). DAP binding was quantified by flow cytometry, in-parallel with temporal (1–4 h) killing by either DAP or comparative prototypic cationic HDPs (hNP-1; LL-37). Multicolor flow cytometry was used to determine kinetic cell responses associated with resistance or susceptibility to these molecules. While overall DAP binding was similar between strains, a significant subpopulation of 351-D10 cells hyper-accumulated DAP (>2–4-fold vs. 351-WT). Further, both DAP and hNP-1 induced cell membrane (CM) hyper-polarization in 351-WT, corresponding to significantly greater temporal DAP-killing (vs. 351-D10). No strain-specific differences in CM permeabilization, lipid turnover or regulated cell death were observed post-exposure to DAP, hNP-1 or LL-37. Thus, the adaptive energetics of the CM appear coupled to the outcomes of interactions of S. mitis-oralis with DAP and selected HDPs. In contrast, altered CM permeabilization, proposed as a major mechanism of action of both DAP and HDPs, did not differentiate DAP-S vs. DAP-R phenotypes in this S. mitis-oralis strain-pair.

scholarly journals Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers

RSC Advances ◽  
2017 ◽  
Vol 7 (31) ◽  
pp. 19081-19084
Author(s):  
Andrea Valsesia ◽  
Patrizia Iavicoli ◽  
Helen Lewis ◽  
Cloé Desmet ◽  
Dora Mehn ◽  
...  
Keyword(s):  
Process Monitoring ◽  
Host Defense ◽  
Phospholipid Bilayers ◽  
Host Defense Peptides ◽  
Defense Peptides ◽  
Membrane Poration

Nanomechanical monitoring of known mechanisms of membrane poration mediated by host defense peptides is reported.

A comparison of host-defense peptides in skin secretions of female Xenopus laevis×Xenopus borealis and X. borealis×X. laevis F1 hybrids

Peptides ◽  
2013 ◽  
Vol 45 ◽  
pp. 1-8 ◽  
Author(s):  
Milena Mechkarska ◽  
Manju Prajeep ◽  
Jérôme Leprince ◽  
Hubert Vaudry ◽  
Mohammed A. Meetani ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Host Defense ◽  
F1 Hybrids ◽  
Host Defense Peptides ◽  
Skin Secretions ◽  
Defense Peptides ◽  
Xenopus Borealis

scholarly journals Host-defense peptides

1996 ◽  
Vol 14 (7) ◽  
pp. 804-804
Author(s):  
Robert L. Erwin
Keyword(s):  
Host Defense ◽  
Host Defense Peptides ◽  
Defense Peptides

Host Defense Peptides as immunomodulators: the other side of the coin

Peptides ◽  
2021 ◽  
pp. 170644
Author(s):  
Ernesto M. Martell ◽  
Melaine González ◽  
Ludger Ständker ◽  
Anselmo J. Otero-González
Keyword(s):  
Host Defense ◽  
The Other ◽  
Host Defense Peptides ◽  
Defense Peptides
Sign in / Sign up

Export Citation Format

Share Document