Diketopiperazine Formation from FPGnK (n = 1–9) Peptides: Rates of Structural Rearrangements and Mechanisms

2021 ◽  
Author(s):  
Zhichao Zhang ◽  
Christopher R. Conant ◽  
Tarick J. El-Baba ◽  
Shannon A. Raab ◽  
Daniel R. Fuller ◽  
...  
Keyword(s):  
Structural Rearrangements ◽  
Diketopiperazine Formation

Influence of Solvents upon Diketopiperazine Formation of FPG8K

2021 ◽  
Author(s):  
Zhi-chao Zhang ◽  
Shannon A. Raab ◽  
David A. Hales ◽  
David E. Clemmer
Keyword(s):  
Diketopiperazine Formation ◽  
Influence Of Solvents

scholarly journals An antisense noncoding RNA enhances translation via localised structural rearrangements of its cognate mRNA

2021 ◽  
Author(s):  
Rodrigo S Reis ◽  
Jules Deforges ◽  
Romy R Schmidt ◽  
Jos H M Schippers ◽  
Yves Poirier
Keyword(s):  
Antisense Rna ◽  
Noncoding Rna ◽  
Regulatory Region ◽  
Structural Rearrangement ◽  
Start Codon ◽  
Structural Rearrangements ◽  
Eukaryotic Genes ◽  
Inhibitory Region ◽  
Rna Interaction

Abstract A large portion of eukaryotic genes are associated with noncoding, natural antisense transcripts (NATs). Despite sharing extensive sequence complementarity with their sense mRNAs, mRNA-NAT pairs elusively often evade dsRNA-cleavage and siRNA-triggered silencing. More surprisingly, some NATs enhance translation of their sense mRNAs by yet unknown mechanism(s). Here we show that translation enhancement of the rice (Oryza sativa) PHOSPHATE1.2 (PHO1.2) mRNA is enabled by specific structural rearrangements guided by its noncoding antisense RNA (cis-NATpho1.2). Their interaction in vitro revealed no evidence of widespread intermolecular dsRNA formation, but rather specific local changes in nucleotide base-pairing, leading to higher flexibility of PHO1.2 mRNA at a key high GC regulatory region inhibiting translation, approximately 350 nucleotides downstream of the start codon. Sense-antisense RNA interaction increased formation of the 80S complex in PHO1.2, possibly by inducing structural rearrangement within this inhibitory region, thus making this mRNA more accessible to 60S. This work presents a framework for nucleotide-resolution studies of functional mRNA-antisense pairs. One-sentence summary: Interaction between PHO1.2 mRNA and its cis-natural antisense transcript enhances translation via a mechanism involving a local conformational shift and disruption of a key inhibitory region.

Blastocyst conversion rate and ploidy in patients with structural rearrangements

2021 ◽  
Author(s):  
Iris G. Insogna ◽  
A. Lanes ◽  
L. Dobson ◽  
E. S. Ginsburg ◽  
C. Racowsky ◽  
...  
Keyword(s):  
Conversion Rate ◽  
Structural Rearrangements

scholarly journals Structural rearrangements in wheat (1BS)–rye (1RS) recombinant chromosomes affect gene dosage and root length

2021 ◽  
Author(s):  
Gilad Gabay ◽  
Junli Zhang ◽  
German Federico Burguener ◽  
Tyson Howell ◽  
Hanchao Wang ◽  
...  
Keyword(s):  
Root Length ◽  
Gene Dosage ◽  
Structural Rearrangements

Ring formation and structural rearrangements of chromosome 1 as secondary changes in uterine leiomyomas with t(12;14)(q14–15;q23–24)

1988 ◽  
Vol 36 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Mef Nilbert ◽  
Sverre Heim ◽  
Nils Mandahl ◽  
Ulla-Maria Flodérus ◽  
Helena Willén ◽  
...  
Keyword(s):  
Ring Formation ◽  
Uterine Leiomyomas ◽  
Chromosome 1 ◽  
Structural Rearrangements

scholarly journals Structural rearrangements of Ru nanoparticles supported on carbon nanotubes under microwave irradiation

2011 ◽  
Vol 47 (38) ◽  
pp. 10716 ◽  
Author(s):  
Bingsen Zhang ◽  
Xiaojuan Ni ◽  
Wei Zhang ◽  
Lidong Shao ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Microwave Irradiation ◽  
Structural Rearrangements ◽  
Ru Nanoparticles

scholarly journals Low-temperature resonance-Raman spectra of Japanese-lacquer-tree (Rhus vernicifera) laccase, type-2-copper-depleted laccase and H2O2-treated type-2-copper-depleted laccase

1983 ◽  
Vol 213 (2) ◽  
pp. 503-506 ◽  
Author(s):  
G Musci ◽  
A Desideri ◽  
L Morpurgo ◽  
A Garnier-Suillerot ◽  
L Tosi
Keyword(s):  
Raman Spectra ◽  
Strong Dependence ◽  
Resonance Raman ◽  
Local Symmetry ◽  
Structural Rearrangements ◽  
Blue Copper ◽  
Copper Site ◽  
Resonance Raman Spectra ◽  
Rhus Vernicifera

Resonance-Raman spectra of Japanese-lacquer-tree (Rhus vernicifera) laccase, type-2-copper-depleted laccase and the latter form treated with H2O2 were measured in liquid and frozen solution, on excitation into the 600 nm absorption band. Significant changes in intensity and/or frequency of the bands lying in the 370-430 cm-1 region were observed on freezing, indicating local structural rearrangements taking place at the blue copper site. These findings corroborate previous suggestions based on e.p.r. measurements and redox data [Morpurgo, Calabrese, Desideri & Rotilio (1981) Biochem. J. 193, 639-642]. They show the strong dependence of the physical properties of blue copper centres on local symmetry. Some conclusions on the origin of the Raman bands are also drawn.

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