Enantioselective Synthesis of Pyrrolizin-1-ones via Lewis Base Catalyzed N-Allylation of N-Silyl Pyrrole Latent Nucleophiles

2019 ◽  
Vol 85 (2) ◽  
pp. 1259-1269 ◽  
Author(s):  
Markus Lange ◽  
You Zi ◽  
Ivan Vilotijevic
Keyword(s):  
Enantioselective Synthesis ◽  
Lewis Base

scholarly journals Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles

2018 ◽  
Vol 57 (26) ◽  
pp. 7800-7803 ◽  
Author(s):  
Kevin J. Schwarz ◽  
Colin M. Pearson ◽  
Gabriel A. Cintron-Rosado ◽  
Peng Liu ◽  
Thomas N. Snaddon
Keyword(s):  
Palladium Catalysis ◽  
Enantioselective Synthesis ◽  
Lewis Base

Recent Progress towards Organocatalyzed Asymmetric (Hetero)Arene Formation

Synthesis ◽  
2020 ◽  
Author(s):  
Tingshun Zhu ◽  
Ke Xu ◽  
Ziyuan Wang
Keyword(s):  
Organic Chemistry ◽  
Hydrogen Bonding ◽  
Recent Progress ◽  
De Novo ◽  
Short Review ◽  
Enantioselective Synthesis ◽  
Lewis Base ◽  
Environmentally Benign ◽  
Tertiary Phosphine ◽  
Target Molecules

AbstractOwing to the importance of arene moieties in organic chemistry, methods for arene construction attract great attention. Besides the traditional substitution strategy from pre-existing arenes, the straightforward formation of arene cores can also provide significant shortcuts towards a wide array of target molecules with different substitution patterns. Among direct arene formation reactions, applying environmentally benign organocatalysis to access arene moieties continues to attract increasing attention. This short review provides a brief summary of recent progress on organocatalyzed de novo (hetero)arene formation and applications in enantioselective synthesis.1 Introduction2 Arene Formation with Non-Covalent Organocatalysts2.1 Arene Formation with Acid Organocatalysts2.2 Arene Formation with Base Organocatalysts2.3 Arene Formation with Hydrogen-Bonding Organocatalysts3 Arene Formation with Covalent Organocatalysts3.1 Arene Formation with Lewis Base Organocatalysts3.1.1 Arene Formation with Secondary Amine Organocatalysts3.1.2 Arene Formation with Tertiary Amine, Tertiary Phosphine and Sulfide Organocatalysts3.1.3 Arene Formation with N-Heterocyclic Carbene Organocatalysts3.2 Arene Formation with Lewis Acid Organocatalysts4 Conclusion

ChemInform Abstract: Enantioselective Synthesis of 4-Substituted 4,5-Dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis Base Catalyzed Hydrosilylation.

ChemInform ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. no-no
Author(s):  
Xing Chen ◽  
Yongsheng Zheng ◽  
Chang Shu ◽  
Weicheng Yuan ◽  
Bo Liu ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Lewis Base

ChemInform Abstract: Regio- and Enantioselective Synthesis of Azole Hemiaminal Esters by Lewis Base Catalyzed Dynamic Kinetic Resolution.

ChemInform ◽  
2016 ◽  
Vol 47 (38) ◽  
Author(s):  
David W. Piotrowski ◽  
Adam S. Kamlet ◽  
Anne-Marie R. Dechert-Schmitt ◽  
Jiangli Yan ◽  
Thomas A. Brandt ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Lewis Base ◽  
Dynamic Kinetic Resolution

scholarly journals An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

2019 ◽  
Vol 17 (7) ◽  
pp. 1787-1790 ◽  
Author(s):  
W. Rush Scaggs ◽  
Toya D. Scaggs ◽  
Thomas N. Snaddon
Keyword(s):  
Acetic Acid ◽  
Palladium Catalysis ◽  
Enantioselective Synthesis ◽  
Lewis Base ◽  
Acetic Acid Esters ◽  
Acid Esters

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters.

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