ChemInform Abstract: Highly Enantioselective Synthesis of Bisoxindoles with Two Vicinal Quaternary Stereocenters via Lewis Base Mediated Addition of Oxindoles to Isatin-Derived Ketimines.

ChemInform ◽  
2014 ◽  
Vol 46 (3) ◽  
pp. no-no
Author(s):  
Zhongkai Tang ◽  
Yan Shi ◽  
Haibin Mao ◽  
Xuebin Zhu ◽  
Weipeng Li ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Lewis Base ◽  
Quaternary Stereocenters

Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines

2014 ◽  
Vol 12 (32) ◽  
pp. 6085-6088 ◽  
Author(s):  
Zhongkai Tang ◽  
Yan Shi ◽  
Haibin Mao ◽  
Xuebin Zhu ◽  
Weipeng Li ◽  
...  
Keyword(s):  
Efficient Method ◽  
Enantioselective Synthesis ◽  
Lewis Base ◽  
Highly Efficient ◽  
Stereogenic Centers ◽  
Quaternary Stereocenters ◽  
Quaternary Stereogenic Centers

A highly efficient method provides access to the bisoxindole structure moiety with two vicinal quaternary stereogenic centers (>99 : 1 dr, >99% ee).

Enantioselective Synthesis of Dihydropyridines Containing Quaternary Stereocenters Through Dearomatization of Pyridinium Salts

ACS Catalysis ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 51-55 ◽  
Author(s):  
Donovan J. Robinson ◽  
Sean P. Spurlin ◽  
John D. Gorden ◽  
Rashad R. Karimov
Keyword(s):  
Enantioselective Synthesis ◽  
Pyridinium Salts ◽  
Quaternary Stereocenters

scholarly journals Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles

2018 ◽  
Vol 57 (26) ◽  
pp. 7800-7803 ◽  
Author(s):  
Kevin J. Schwarz ◽  
Colin M. Pearson ◽  
Gabriel A. Cintron-Rosado ◽  
Peng Liu ◽  
Thomas N. Snaddon
Keyword(s):  
Palladium Catalysis ◽  
Enantioselective Synthesis ◽  
Lewis Base

Palladium(ii)-catalyzed asymmetric C–H carbonylation to diverse isoquinoline derivatives bearing all-carbon quaternary stereocenters

2020 ◽  
Vol 56 (78) ◽  
pp. 11605-11608
Author(s):  
Yan Li ◽  
Xiu-Fen Cheng ◽  
Fan Fei ◽  
Tian-Rui Wu ◽  
Kang-Jie Bian ◽  
...  
Keyword(s):  
Late Stage ◽  
Enantioselective Synthesis ◽  
One Step ◽  
Quaternary Stereocenters ◽  
Quaternary Stereocenter ◽  
Isoquinoline Derivatives

Enantioselective synthesis of isoquinoline derivatives bearing an all-carbon quaternary stereocenter in one step via asymmetric Pd(ii)-catalyzed C–H activation and multiple late-stage derivatizations.

Recent Progress towards Organocatalyzed Asymmetric (Hetero)Arene Formation

Synthesis ◽  
2020 ◽  
Author(s):  
Tingshun Zhu ◽  
Ke Xu ◽  
Ziyuan Wang
Keyword(s):  
Organic Chemistry ◽  
Hydrogen Bonding ◽  
Recent Progress ◽  
De Novo ◽  
Short Review ◽  
Enantioselective Synthesis ◽  
Lewis Base ◽  
Environmentally Benign ◽  
Tertiary Phosphine ◽  
Target Molecules

AbstractOwing to the importance of arene moieties in organic chemistry, methods for arene construction attract great attention. Besides the traditional substitution strategy from pre-existing arenes, the straightforward formation of arene cores can also provide significant shortcuts towards a wide array of target molecules with different substitution patterns. Among direct arene formation reactions, applying environmentally benign organocatalysis to access arene moieties continues to attract increasing attention. This short review provides a brief summary of recent progress on organocatalyzed de novo (hetero)arene formation and applications in enantioselective synthesis.1 Introduction2 Arene Formation with Non-Covalent Organocatalysts2.1 Arene Formation with Acid Organocatalysts2.2 Arene Formation with Base Organocatalysts2.3 Arene Formation with Hydrogen-Bonding Organocatalysts3 Arene Formation with Covalent Organocatalysts3.1 Arene Formation with Lewis Base Organocatalysts3.1.1 Arene Formation with Secondary Amine Organocatalysts3.1.2 Arene Formation with Tertiary Amine, Tertiary Phosphine and Sulfide Organocatalysts3.1.3 Arene Formation with N-Heterocyclic Carbene Organocatalysts3.2 Arene Formation with Lewis Acid Organocatalysts4 Conclusion

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