Synthesis of the Methyl Analog of 2′-O,4′-C-Ethylene-Bridged 5-Methyluridine via Intramolecular Radical Cyclization and Properties of Modified Oligonucleotides

2019 ◽  
Vol 84 (14) ◽  
pp. 9093-9100 ◽  
Author(s):  
Yuta Ito ◽  
Norika Tsutsui ◽  
Takashi Osawa ◽  
Yoshiyuki Hari
Keyword(s):  
Radical Cyclization ◽  
Modified Oligonucleotides ◽  
Methyl Analog

Click conjugation of 4'-C-modified oligonucleotides

2011 ◽  
Author(s):  
Anu Kiviniemi ◽  
Pasi Virta ◽  
Harri Lönnberg
Keyword(s):  
Modified Oligonucleotides

Fluoride-Catalyzed Addition of PhSCF2SiMe3toN-Substituted Cyclic Imides Followed by Radical Cyclization: General Synthetic Strategy ofgem-Difluoromethylenated 1-Azabicyclic Compounds

2009 ◽  
Vol 74 (10) ◽  
pp. 3798-3805 ◽  
Author(s):  
Teerawut Bootwicha ◽  
Duanghathai Panichakul ◽  
Chutima Kuhakarn ◽  
Samran Prabpai ◽  
Palangpon Kongsaeree ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Synthetic Strategy ◽  
Cyclic Imides ◽  
Azabicyclic Compounds

scholarly journals Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 628
Author(s):  
Dagmara Baraniak ◽  
Jerzy Boryski
Keyword(s):  
Nucleic Acids ◽  
State Of The Art ◽  
Modified Oligonucleotides ◽  
Synthetic Genes ◽  
Chemically Modified ◽  
Amide Linkage ◽  
Dna And Rna ◽  
Modified Dna ◽  
Modified Nucleic Acids ◽  
Non Coding Rnas

This review covers studies which exploit triazole-modified nucleic acids in the range of chemistry and biology to medicine. The 1,2,3-triazole unit, which is obtained via click chemistry approach, shows valuable and unique properties. For example, it does not occur in nature, constitutes an additional pharmacophore with attractive properties being resistant to hydrolysis and other reactions at physiological pH, exhibits biological activity (i.e., antibacterial, antitumor, and antiviral), and can be considered as a rigid mimetic of amide linkage. Herein, it is presented a whole area of useful artificial compounds, from the clickable monomers and dimers to modified oligonucleotides, in the field of nucleic acids sciences. Such modifications of internucleotide linkages are designed to increase the hybridization binding affinity toward native DNA or RNA, to enhance resistance to nucleases, and to improve ability to penetrate cell membranes. The insertion of an artificial backbone is used for understanding effects of chemically modified oligonucleotides, and their potential usefulness in therapeutic applications. We describe the state-of-the-art knowledge on their implications for synthetic genes and other large modified DNA and RNA constructs including non-coding RNAs.

Iron-Catalysed Radical Cyclization to Synthesize Germanium-Substituted Indolo[2,1-a]isoquinolin-6(5H)-ones and Indolin-2-ones

2021 ◽  
Author(s):  
Yani Luo ◽  
Tian Tian ◽  
Yasushi Nishihara ◽  
Leiyang Lv ◽  
Zhiping Li
Keyword(s):  
Radical Cyclization ◽  
One Pot ◽  
Efficient Strategy

A simple and efficient strategy for iron-catalysed cascade radical cyclization was developed, by which an array of germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones were obtained in one pot with germanium hydrides as...

Atom-transfer radical cyclization of α-bromocarboxamides under organophotocatalytic conditions

2021 ◽  
Vol 69 ◽  
pp. 152952
Author(s):  
Naoki Tsuchiya ◽  
Yusei Nakashima ◽  
Goki Hirata ◽  
Takashi Nishikata
Keyword(s):  
Radical Cyclization ◽  
Atom Transfer ◽  
Atom Transfer Radical Cyclization

Regioselective Synthesis of 2,3‐Dihydrobenzo[ f ]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

2021 ◽  
Vol 363 (4) ◽  
pp. 1038-1043
Author(s):  
Ying‐Chun He ◽  
Yan‐Mei Yan ◽  
Zhen‐Xing Ren ◽  
Yong‐Zhao Wang ◽  
Qiang Yu ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis
Sign in / Sign up

Export Citation Format

Share Document