Metal Free C–H Functionalization Enabled Diastereoselective Multicomponent Reaction of N-Heterocycles to Fused Heteropolycycles

2018 ◽  
Vol 83 (16) ◽  
pp. 8874-8887 ◽  
Author(s):  
Sumana Mandal ◽  
Soumita Dwari ◽  
Chandan K. Jana
Keyword(s):  
Multicomponent Reaction ◽  
Metal Free

A transition-metal-free multicomponent reaction towards constructing chiral 2H-1,4-benzoxazine scaffolds

2020 ◽  
Vol 22 (21) ◽  
pp. 7506-7512
Author(s):  
Lixiang Zhu ◽  
Xiaoyu Ren ◽  
Juan Du ◽  
Jia-Hong Wu ◽  
Jian-Ping Tan ◽  
...  
Keyword(s):  
Transition Metal ◽  
Multicomponent Reaction ◽  
Phosphonium Salt ◽  
Cascade Reaction ◽  
Metal Free

A transition-metal-free multicomponent cascade reaction of α-halogenated ketones, ortho-aminophenols, and aldehydes using a dipeptide phosphonium salt catalyst was developed for the construction of various 2H-1,4-benzoxazines.

ChemInform Abstract: Metal-Free, Acid-Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction.

ChemInform ◽  
2014 ◽  
Vol 45 (22) ◽  
pp. no-no
Author(s):  
Chung-Yu Chen ◽  
Wan-Ping Hu ◽  
Pi-Cheng Yan ◽  
Gopal Chandru Senadi ◽  
Jeh-Jeng Wang
Keyword(s):  
Multicomponent Reaction ◽  
Free Acid ◽  
Metal Free ◽  
Imidazole Derivatives

scholarly journals Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

2018 ◽  
Vol 14 ◽  
pp. 2689-2697 ◽  
Author(s):  
Robby Vroemans ◽  
Yenthel Verhaegen ◽  
My Tran Thi Dieu ◽  
Wim Dehaen
Keyword(s):  
Multicomponent Reaction ◽  
Mechanochemical Synthesis ◽  
Solvent Free ◽  
Viable Alternative ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Biologically Relevant ◽  
Metal Free ◽  
Organic Azides ◽  
Solvent Free Conditions

A new metal-free one-pot three-component procedure towards fully substituted triazolochromenes has been developed, starting from commercially available materials. Salicylaldehydes and nitroalkenes were reacted under solvent-free conditions, followed by a 1,3-dipolar cycloaddition of the intermediate 3-nitro-2H-chromenes with organic azides in a one-pot two-step sequence. The triazolochromenes were formed with complete regioselectivity and new biologically relevant structures were synthesized via extension of the developed procedure and via postfunctionalization. The mechanochemical synthesis was carried out for several salicylaldehydes and gave a clear improvement in the yield of the corresponding triazolochromenes and consequently showed to be a viable alternative for solid salicylaldehydes.

scholarly journals Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Shivanand Merugu ◽  
Vijaya Kumar Ponnamaneni ◽  
Ravi Varala ◽  
Syed Farooq Adil ◽  
Mujeeb Khan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Multicomponent Reaction ◽  
Biological Evaluation ◽  
Anhydrous Ethanol ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Metal Free ◽  
Substituted Benzaldehydes

A series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields. The compounds have been synthesized from 3-(2-bromoacetyl)chromen-2-ones (1), 5-amino-1,3,4-thiadiazole-2-thiol (2), and substituted benzaldehydes (3) in anhydrous ethanol and conc. H2SO4. Subsequently, all the synthesized compounds have been screened for their antimicrobial activity and characterized by analytical and spectral data.

scholarly journals A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-f]quinoline]-8,5′-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolines via selective multiple C–C bond formation under metal-free conditions

RSC Advances ◽  
2020 ◽  
Vol 10 (33) ◽  
pp. 19600-19609 ◽  
Author(s):  
Divyang M. Patel ◽  
Hetal J. Patel ◽  
José M. Padrón ◽  
Hitendra M. Patel
Keyword(s):  
Multicomponent Reaction ◽  
Barbituric Acid ◽  
Bond Formation ◽  
Substrate Selectivity ◽  
The Novel ◽  
Metal Free ◽  
Barbituric Acid Derivatives

Substrate selectivity in the novel multi-component reaction of 5-aminoindazole, barbituric acid derivatives and aldehyde is explored.

Beyond conventional routes, an unprecedented metal-free chemoselective synthesis of anthranilate esters via a multicomponent reaction (MCR) strategy

2015 ◽  
Vol 51 (63) ◽  
pp. 12673-12676 ◽  
Author(s):  
Satavisha Sarkar ◽  
Abu T. Khan
Keyword(s):  
Multicomponent Reaction ◽  
Metal Free ◽  
Chemoselective Synthesis

A hitherto unreported route for the synthesis of anthranilate esters is demonstrated using 2-nitrobenzaldehyde, malonitrile and an alcohol or amine via a metal and oxidant free multicomponent reaction (MCR) strategy.

Metal-Free Graphene Oxide Promoted a Novel Multicomponent Reaction for the Synthesis of 3-Substituted Quinazolinones Using DMSO as One Carbon Synthon

2019 ◽  
Vol 4 (4) ◽  
pp. 1176-1179 ◽  
Author(s):  
Sonal Hada ◽  
Mohammed Shahrukh Khan Zai ◽  
Priyanka Roat ◽  
Ved Prakash Verma ◽  
Anuj Kumar Shah ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Multicomponent Reaction ◽  
Metal Free ◽  
Free Graphene
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