Rhodium-Catalyzed Regioselective Double Annulation of Enaminones with Propargyl Alcohols: Rapid Access to Arylnapthalene Lignan Derivatives

Visible-light-induced remote C(sp3)-H sulfonylvinylation: assembly of cyanoalkylated vinyl sulfones

Organic Chemistry Frontiers ◽

10.1039/d1qo00732g ◽

2021 ◽

Author(s):

Ping Bao ◽

Feiyan Yu ◽

Fu-Sheng He ◽

Zhimei Tang ◽

Wei-Ping Deng ◽

...

Keyword(s):

Visible Light ◽

Rapid Access ◽

Three Component Reaction ◽

Propargyl Alcohols

A photoinduced sulfonylvinylation of unactivated C(sp3)-H bond through a three-component reaction of propargyl alcohols, potassium metabisulfite and cycloketone oxime esters is developed. This approach enables rapid access to cyanoalkylated vinyl...

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Weak Bases‐Mediated Modified Favorskii Reaction‐Type Direct Alkynylation/( E )‐Alkenylation: A Unified Rapid Access to α,β‐Unsaturated Ketones and Propargyl Alcohols

Asian Journal of Organic Chemistry ◽

10.1002/ajoc.201900601 ◽

2019 ◽

Vol 8 (12) ◽

pp. 2257-2268 ◽

Cited By ~ 3

Author(s):

Mohit K. Tiwari ◽

Lalit Yadav ◽

Bharti Rajesh Kumar Shyamlal ◽

Sandeep Chaudhary

Keyword(s):

Reaction Type ◽

Unsaturated Ketones ◽

Rapid Access ◽

Weak Bases ◽

Favorskii Reaction ◽

Propargyl Alcohols

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Modern Annulation Strategies for the Synthesis of Cyclo[b]fused Indoles

Synlett ◽

10.1055/s-0037-1610336 ◽

2018 ◽

Vol 30 (03) ◽

pp. 245-251 ◽

Cited By ~ 5

Author(s):

Edgar Haak

Keyword(s):

Broad Spectrum ◽

Biological Activities ◽

Molecular Structures ◽

Selective Synthesis ◽

Indole Derivatives ◽

Rapid Access ◽

Propargyl Alcohols

2,3-Annulated indoles exhibit a broad spectrum of biological activities. Various annulation strategies are applied to generate these scaffolds from prefunctionalized aniline or indole derivatives. Only a few methodologies allow the direct annulation of indole itself, often associated with regioselectivity issues or restrictions on available substitution patterns. More recently, ruthenium-catalyzed cascade transformations of readily available propargyl alcohols have been applied to the selective synthesis of various cyclo[b]fused indoles directly from indole. These efficient processes provide rapid access to intricate molecular structures from simple starting materials and facilitate the preparation of drug-like molecules.

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A district general hospital experience of the rapid access referral for colorectal cancers

Endoscopy ◽

10.1055/s-2005-922878 ◽

2006 ◽

Vol 37 (12) ◽

Author(s):

RK Choudhary ◽

D Debnath ◽

KA Gunning

Keyword(s):

General Hospital ◽

District General Hospital ◽

Colorectal Cancers ◽

Rapid Access ◽

Hospital Experience

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Rapid access digital data acquisition system

10.2514/6.1969-323 ◽

1969 ◽

Author(s):

R. NELSON

Keyword(s):

Data Acquisition ◽

Data Acquisition System ◽

Digital Data ◽

Acquisition System ◽

Rapid Access ◽

Digital Data Acquisition System ◽

Digital Data Acquisition

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Four-year audit on molecular testing in metastatic lung cancer on small biopsy/cytology samples in an Irish rapid access lung cancer centre

10.26226/morressier.578f37fdd462b8028d8901ed ◽

2016 ◽

Author(s):

Aurelie Fabre

Keyword(s):

Lung Cancer ◽

Molecular Testing ◽

Metastatic Lung Cancer ◽

Cancer Centre ◽

Rapid Access ◽

Metastatic Lung

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Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products

10.26434/chemrxiv.7961633.v1 ◽

2019 ◽

Author(s):

De-Wei Gao ◽

Yang Gao ◽

Huiling Shao ◽

Tian-Zhang Qiao ◽

Xin Wang ◽

...

Keyword(s):

Organic Synthesis ◽

Medicinal Chemistry ◽

Proteasome Inhibitors ◽

Building Blocks ◽

Unique Role ◽

Efficient Strategy ◽

Carbon Centers ◽

Rapid Access ◽

Cascade Catalysis ◽

Privileged Scaffolds

Enantioenriched α-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks in organic synthesis. Recently, CuH-catalyzed asymmetric alkene hydrofunctionalization has become a powerful tool to construct stereogenic carbon centers. In contrast, applying CuH cascade catalysis to achieve reductive 1,1-difunctionalization of alkynes remains an important, but largely unaddressed, synthetic challenge. Herein, we report an efficient strategy to synthesize α-aminoboronates via CuH-catalyzed hydroboration/hydroamination cascade of readily available alkynes. Notably, this transformation selectively delivers the desired 1,1-heterodifunctionalized product in favor of alternative homodifunctionalized, 1,2-heterodifunctionalized, or reductively monofunctionalized byproducts, thereby offering rapid access to these privileged scaffolds with high chemo-, regio- and enantioselectivity.

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