Gentianelloids A and B: Immunosuppressive 10,11-seco-Gentianellane Sesterterpenoids from the Traditional Uighur Medicine Gentianella turkestanorum

2020 ◽  
Vol 85 (8) ◽  
pp. 5511-5515
Author(s):  
Kai Guo ◽  
Xin Liu ◽  
Ting-Ting Zhou ◽  
Yan-Chun Liu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Traditional Uighur Medicine

scholarly journals Binafuxi Granules in the treatment of common cold with heat syndrome based on traditional Uighur medicine: study protocol for a multicenter randomized controlled trial

2018 ◽  
Author(s):  
Bing Mao ◽  
Jie Min ◽  
Bin She ◽  
Xin Zhang ◽  
Yan Chen
Keyword(s):  
Clinical Trial ◽  
Common Cold ◽  
Dose Group ◽  
Syndrome Differentiation ◽  
Control Group ◽  
Placebo Control ◽  
High Dose ◽  
Traditional Uighur Medicine ◽  
Multicenter Randomized Controlled Trial ◽  
Heat Syndrome

Abstract Background Common cold is a highly prevalent illness with significant impact on society and health care. Common cold with heat syndrome (CCHS) is one of most common type based on traditional Uighur medicine (TUM) syndrome differentiation, which is widely used in Central Asia. This study is designed to explore the efficacy, safety and optimal therapeutic dosage of Binafuxi Granules in treating CCHS. Methods This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. A total of 240 patients will be recruited from 5 centers across China and randomly assigned to the high-dose group, low-dose group or placebo control group in a 1:1:1 ratio. All subjects will receive test drugs twice daily for 3 days. The primary outcome is the time to fever relief. Secondary outcomes include the time to fever clearance, duration of primary symptoms and each symptom, change in TUM symptom score. Discussion This is the first placebo-controlled randomized clinical trial for a Uighur medicine in treating common cold. It will provide robust evidence on the efficacy and safety of Binafuxi Granules in the treatment of CCHS. Trial registration The registration number is ChiCTR-IIR-17013379, which was assigned by the Chinese Clinical Trial Registry on 14 November 2017.

scholarly journals Binafuxi Granules in the treatment of common cold with heat syndrome based on traditional Uighur medicine: study protocol for a multicenter randomized controlled trial

2019 ◽  
Author(s):  
Jie Min ◽  
Bin She ◽  
Xin Zhang ◽  
Bing Mao ◽  
Yan Chen
Keyword(s):  
Clinical Trial ◽  
Common Cold ◽  
Dose Group ◽  
Syndrome Differentiation ◽  
Control Group ◽  
Placebo Control ◽  
High Dose ◽  
Traditional Uighur Medicine ◽  
Multicenter Randomized Controlled Trial ◽  
Heat Syndrome

Abstract Background: Common cold is a highly prevalent illness with significant impact on society and health care. Common cold with heat syndrome (CCHS) is one of most common type based on traditional Uighur medicine (TUM) syndrome differentiation, which is widely used in Central Asia. The study is designed to explore the efficacy, safety and optimal therapeutic dosage of Binafuxi Granules in treating CCHS. Methods: This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. 240 participants will be enrolled from 5 centers across China and randomly assigned to the high-dose group, low-dose group or placebo control group in a 1:1:1 ratio. All eligible patients will receive test drugs twice daily for 3 days. The primary outcome is the time to fever relief. Secondary outcomes include the time to fever clearance, duration of primary symptoms and each symptom, change in TUM symptom score. Discussion: This is the first placebo-controlled randomized clinical trial for a Uighur medicine in treating common cold. It will provide robust evidence on the efficacy and safety of Binafuxi Granules in the treatment of CCHS. Trial registration: The registration number is ChiCTR-IIR-17013379, which was assigned by the Chinese Clinical Trial Registry on 14 November 2017.

scholarly journals Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Nurmuhammat Amat ◽  
Parida Hoxur ◽  
Dang Ming ◽  
Aynur Matsidik ◽  
Anake Kijjoa ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Serum Levels ◽  
Latency Time ◽  
Enhancing Effect ◽  
Traditional Uighur Medicine ◽  
Y Maze ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq ◽  
The Brain ◽  
Memory Enhancing

Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latency time in the step-through test and the decrease of the latency time in the Y-maze test. Treatment with ASMq was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and -endorphin (-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ASMq was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT) and 3,4-dihydroxyphenylalanine (DOPAC). The results obtained from this study suggested that the memory-enhancing effect of ASMq was mediated through regulations of neurochemical and neuroendocrine systems.

Immunosuppressive gentianellane-type sesterterpenoids from the traditional Uighur medicine Gentianella turkestanorum

2021 ◽  
Vol 187 ◽  
pp. 112780
Author(s):  
Kai Guo ◽  
Yan-Chun Liu ◽  
Yan Liu ◽  
Han Zhang ◽  
Wen-Yuan Li ◽  
...  
Keyword(s):  
Traditional Uighur Medicine

scholarly journals Binafuxi Granules in the treatment of common cold with heat syndrome based on traditional Uighur medicine: study protocol for a multicenter randomized controlled trial

2019 ◽  
Author(s):  
Jie Min ◽  
Bin She ◽  
Xin Zhang ◽  
Bing Mao ◽  
Yan Chen
Keyword(s):  
Clinical Trial ◽  
Common Cold ◽  
Dose Group ◽  
Syndrome Differentiation ◽  
Control Group ◽  
Placebo Control ◽  
High Dose ◽  
Traditional Uighur Medicine ◽  
Multicenter Randomized Controlled Trial ◽  
Heat Syndrome

Abstract Background Common cold is a highly prevalent illness with significant impact on society and health care. Common cold with heat syndrome (CCHS) is one of most common type based on traditional Uighur medicine (TUM) syndrome differentiation, which is widely used in Central Asia. The study is designed to explore the efficacy, safety and optimal therapeutic dosage of Binafuxi Granules in treating CCHS. Methods This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. A total of 240 patients will be recruited from 5 centers across China and randomly assigned to the high-dose group, low-dose group or placebo control group in a 1:1:1 ratio. All subjects will receive test drugs twice daily for 3 days. The primary outcome is the time to fever relief. Secondary outcomes include the time to fever clearance, duration of primary symptoms and each symptom, change in TUM symptom score. Discussion This is the first placebo-controlled randomized clinical trial for a Uighur medicine in treating common cold. It will provide robust evidence on the efficacy and safety of Binafuxi Granules in the treatment of CCHS. Trial registration The registration number is ChiCTR-IIR-17013379, which was assigned by the Chinese Clinical Trial Registry on 14 November 2017.

scholarly journals An Assessment Of Traditional Uighur Medicine In Current Xinjiang Region (China)

2014 ◽  
Vol 11 (2) ◽  
pp. 301 ◽  
Author(s):  
ZQ Ma ◽  
H Hu ◽  
TT He ◽  
H Guo ◽  
MY Zhang ◽  
...  
Keyword(s):  
Traditional Uighur Medicine

scholarly journals Antioxidant and Preventive Effects of Extract fromNymphaea candidaFlower onIn VitroImmunological Liver Injury of Rat Primary Hepatocyte Cultures

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jun Zhao ◽  
Tao Liu ◽  
Long Ma ◽  
Ming Yan ◽  
Zhengyi Gu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Antioxidant Capacity ◽  
Antioxidant Activities ◽  
Reducing Power ◽  
Rat Hepatocytes ◽  
Butylated Hydroxytoluene ◽  
Traditional Uighur Medicine ◽  
Cultured Rat Hepatocytes

Nymphaea candidais traditional Uighur medicine that is commonly used to treat head pains, cough, hepatitis and hypertension in Xinjiang of China. In this article, the extract ofN. candidawas measured for antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals scavenging assay and reducing power determination, and compared with those of the positive controls of butylated hydroxytoluene (BHT) and gallic acid (GA). The active extract was further purified by liquid-liquid partition to afford four fractions, of which the ethyl acetate-soluble (EA) fraction (NCE) exhibited the strongest antioxidant capacity with IC50value of 12.6 g/mL for DPPH. Thirteen phenolic compounds were isolated from this fraction, and they all showed significant antioxidant activities in DPPH model system. Furthermore, NCE showed potent antioxidant capacity with IC50value of 59.32 g/mL, 24.48 g/mL and 86.85 g/mL, for ,·OH and H2O2radicals, respectively. Moreover, NCE on BCG plus LPS-induced immunological liver injury was evaluated using primary cultured rat hepatocytes. NCE produced significant hepatoprotective effects as evidenced by decreased supernatant enzyme activities (AST—aspartate transaminase,P<  .01; ALT—alanine transferase,P<  .01) and nitric oxide (NO,P<  .01) production. These results revealed thein vitroantioxidant and hepatoprotective activities of NCE against immunological liver injury. Further investigations are necessary to verify these activitiesin vivo.

scholarly journals Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Sajida Abdureyim ◽  
Nurmuhammat Amat ◽  
Anwar Umar ◽  
Halmurat Upur ◽  
Benedicte Berke ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Bronchoalveolar Lavage Fluid ◽  
Histological Analysis ◽  
Inflammatory Cells ◽  
Lavage Fluid ◽  
Heme Oxygenase 1 ◽  
Asthma Model ◽  
Traditional Uighur Medicine ◽  
Anti Inflammatory ◽  
Marked Suppression

Ravan Napas(RN) is a traditional formula used to treat pulmonary symptoms and diseases such as coughing, breathing difficulty, and asthma in traditional Uighur medicine. The purpose of this study was to investigate the anti-inflammatory, and immuno-modulatory activity of RN in a well-characterized animal model of allergic asthma. Rats were sensitized with intraperitoneal (ip) ovalbumin (OVA) and alum, and then challenged with OVA aerosols. The asthma model rats were treated with RN; saline- and dexamethasone- (DXM-) treated rats served as normal and model controls. The bronchoalveolar lavage fluid (BALF) cellular differential and the concentrations of sICAM-1, IL-4, IL-5, TNF-α, INF-γ, and IgE in serum were measured. Lung sections underwent histological analysis. The immunohistochemistry S-P method was used to measure the expression of ICAM-1 and HO-1 in the lung. RN significantly reduced the number of inflammatory cells in BALF and lung tissues, decreased sICAM-1, IL-4, IL-5, TNF-α, and IgE in serum, and increased serum INF-γ. There was a marked suppression of ICAM-1 and HO-1 expression in the lung. Our results suggest that RN may have an anti-inflammatory and immuneregulatory effect on allergic bronchial asthma by modulating the balance between Th1/Th2 cytokines.

Sign in / Sign up

Export Citation Format

Share Document