Special Issue in Honor of William Fenical, a Pioneer in Marine Natural Products Discovery and Drug Development

2015 ◽  
Vol 78 (3) ◽  
pp. 347-348
Author(s):  
Bradley S. Moore ◽  
William H. Gerwick
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Marine Natural Products ◽  
Special Issue ◽  
Natural Products Discovery

scholarly journals CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean

2020 ◽  
Vol 49 (D1) ◽  
pp. D509-D515
Author(s):  
Chuanyu Lyu ◽  
Tong Chen ◽  
Bo Qiang ◽  
Ningfeng Liu ◽  
Heyu Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Natural Products ◽  
Terrestrial Plants ◽  
Activity Data ◽  
Related Data ◽  
Free Data ◽  
Pharmacokinetic Properties ◽  
Natural Products Discovery ◽  
User Friendly

Abstract Marine organisms are expected to be an important source of inspiration for drug discovery after terrestrial plants and microorganisms. Despite the remarkable progress in the field of marine natural products (MNPs) chemistry, there are only a few open access databases dedicated to MNPs research. To meet the growing demand for mining and sharing for MNPs-related data resources, we developed CMNPD, a comprehensive marine natural products database based on manually curated data. CMNPD currently contains more than 31 000 chemical entities with various physicochemical and pharmacokinetic properties, standardized biological activity data, systematic taxonomy and geographical distribution of source organisms, and detailed literature citations. It is an integrated platform for structure dereplication (assessment of novelty) of (marine) natural products, discovery of lead compounds, data mining of structure-activity relationships and investigation of chemical ecology. Access is available through a user-friendly web interface at https://www.cmnpd.org. We are committed to providing a free data sharing platform for not only professional MNPs researchers but also the broader scientific community to facilitate drug discovery from the ocean.

Drug development from marine natural products

2008 ◽  
Vol 8 (1) ◽  
pp. 69-85 ◽  
Author(s):  
Tadeusz F. Molinski ◽  
Doralyn S. Dalisay ◽  
Sarah L. Lievens ◽  
Jonel P. Saludes
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Marine Natural Products

Optimized Marine Natural Products Discovery and Screening: Searching for Novel “Superbug” Antibiotics

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
V Macherla ◽  
M Hensler ◽  
H Houson ◽  
P Adhikari ◽  
W Thienphrapa ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Natural Products Discovery

The role of biogeography in marine natural products discovery

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
M Munro ◽  
J Blunt ◽  
S Dabb ◽  
MC Leal ◽  
R Calado
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Natural Products Discovery
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