Structural Simplification of Marine Natural Products: Discovery of Hamacanthin Derivatives Containing Indole and Piperazinone as Novel Antiviral and Anti-phytopathogenic-fungus Agents

2021 ◽  
Vol 69 (35) ◽  
pp. 10093-10103
Author(s):  
Tienan Wang ◽  
Lin Li ◽  
Yanan Zhou ◽  
Aidang Lu ◽  
Hongyan Li ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Phytopathogenic Fungus ◽  
Natural Products Discovery ◽  
Structural Simplification

scholarly journals CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean

2020 ◽  
Vol 49 (D1) ◽  
pp. D509-D515
Author(s):  
Chuanyu Lyu ◽  
Tong Chen ◽  
Bo Qiang ◽  
Ningfeng Liu ◽  
Heyu Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Natural Products ◽  
Terrestrial Plants ◽  
Activity Data ◽  
Related Data ◽  
Free Data ◽  
Pharmacokinetic Properties ◽  
Natural Products Discovery ◽  
User Friendly

Abstract Marine organisms are expected to be an important source of inspiration for drug discovery after terrestrial plants and microorganisms. Despite the remarkable progress in the field of marine natural products (MNPs) chemistry, there are only a few open access databases dedicated to MNPs research. To meet the growing demand for mining and sharing for MNPs-related data resources, we developed CMNPD, a comprehensive marine natural products database based on manually curated data. CMNPD currently contains more than 31 000 chemical entities with various physicochemical and pharmacokinetic properties, standardized biological activity data, systematic taxonomy and geographical distribution of source organisms, and detailed literature citations. It is an integrated platform for structure dereplication (assessment of novelty) of (marine) natural products, discovery of lead compounds, data mining of structure-activity relationships and investigation of chemical ecology. Access is available through a user-friendly web interface at https://www.cmnpd.org. We are committed to providing a free data sharing platform for not only professional MNPs researchers but also the broader scientific community to facilitate drug discovery from the ocean.

Marine‐natural‐products for biocides development: first discovery of meridianin alkaloids as antiviral and anti‐phytopathogenic‐fungus agents

2019 ◽  
Vol 76 (10) ◽  
pp. 3369-3376 ◽  
Author(s):  
Ji Dong ◽  
Shi‐sheng Huang ◽  
Ya‐nan Hao ◽  
Zi‐wen Wang ◽  
Yu‐xiu Liu ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Phytopathogenic Fungus

Optimized Marine Natural Products Discovery and Screening: Searching for Novel “Superbug” Antibiotics

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
V Macherla ◽  
M Hensler ◽  
H Houson ◽  
P Adhikari ◽  
W Thienphrapa ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Natural Products Discovery

The role of biogeography in marine natural products discovery

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
M Munro ◽  
J Blunt ◽  
S Dabb ◽  
MC Leal ◽  
R Calado
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Natural Products Discovery

The discoipyrroles: A multifaceted approach to understand a novel family of marine natural products

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Multifaceted Approach
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