Reactive Separation of Benzeneacetic Acid with Tri-n-caprylyl Amine: Equilibrium and Modeling

2016 ◽  
Vol 61 (7) ◽  
pp. 2335-2345 ◽  
Author(s):  
Kanti Kumar Athankar ◽  
Kailas L. Wasewar ◽  
Mahesh N. Varma ◽  
Diwakar Z. Shende
Keyword(s):  
Reactive Separation ◽  
Benzeneacetic Acid

scholarly journals Perspectives on Reactive Separation and Removal of Hydrogen Sulfide

2021 ◽  
pp. 100105
Author(s):  
Kalyani Jangam ◽  
Yu-Yen Chen ◽  
Lang Qin ◽  
Liang-Shih Fan
Keyword(s):  
Hydrogen Sulfide ◽  
Reactive Separation

A Continuous Reactive Separation Process for Ethyl Lactate Formation

2005 ◽  
Vol 9 (5) ◽  
pp. 599-607 ◽  
Author(s):  
Navinchandra Asthana ◽  
Aspi Kolah ◽  
Dung T. Vu ◽  
Carl T. Lira ◽  
Dennis J. Miller
Keyword(s):  
Separation Process ◽  
Ethyl Lactate ◽  
Lactate Formation ◽  
Reactive Separation

The use of ionic liquids as efficient extraction medium in the reactive separation of cycloolefins from cyclohexane

2009 ◽  
Vol 154 (1-3) ◽  
pp. 241-245 ◽  
Author(s):  
Daniel Gorri ◽  
Alicia Ruiz ◽  
Alfredo Ortiz ◽  
Inmaculada Ortiz
Keyword(s):  
Ionic Liquids ◽  
Efficient Extraction ◽  
Reactive Separation

Robust Bijels for Reactive Separation via Silica-Reinforced Nanoparticle Layers

ACS Nano ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Giuseppe Di Vitantonio ◽  
Tiancheng Wang ◽  
Martin F. Haase ◽  
Kathleen J. Stebe ◽  
Daeyeon Lee
Keyword(s):  
Reactive Separation

In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid

Pharmacology ◽  
2018 ◽  
Vol 103 (1-2) ◽  
pp. 10-16 ◽  
Author(s):  
Alessia Cenani ◽  
Robert J. Brosnan ◽  
Heather K. Knych
Keyword(s):  
Gabaa Receptor ◽  
Gabaa Receptors ◽  
Water Solubility ◽  
Plasma Concentrations ◽  
Receptor Activation ◽  
Receptor Interaction ◽  
Dependent Manner ◽  
Benzeneacetic Acid

Background: Propanidid is a γ-aminobutyric acid type A (GABAA) receptor agonist general anesthetic and its primary metabolite is 4-(2-[diethylamino]-2-oxoethoxy)-3-methoxy-benzeneacetic acid (DOMBA). Despite having a high water solubility at physiologic pH that might predict low-affinity GABAA receptor interactions, DOMBA is reported to have no effect on GABAA receptor currents, possibly because the DOMBA concentrations studied were simply insufficient to modulate GABAA receptors. Our objectives were to measure the propanidid and DOMBA concentration responses on ­GABAA receptors and to measure the behavioral responses of DOMBA in mice at concentrations that affect GABAA receptor currents in vitro. Methods: GABAA receptors were expressed in oocytes using clones for the human GABAA α1, β2 and γ2s subunits. The effects of DOMBA (0.2–10 mmol/L) and propanidid (0.001–1 mmol/L) on oocyte GABAA currents were studied using standard 2-electrode voltage clamp techniques. Based on in vitro results, 6 mice received ­DOMBA 32 mg intraperitoneal and were observed for occurrence of neurologic effects and DOMBA plasma concentration was measured by liquid chromatography tandem mass spectrometry. Results: DOMBA both directly activates GABAA receptors and antagonizes its GABA-mediated opening in a concentration-dependent manner at concentrations between 5–10 and 0.5–10 mmol/L respectively. In vivo, DOMBA produced rapid onset sedation at plasma concentrations that correlate with direct GABAA receptor activation. Conclusion: DOMBA modulation of GABAA receptors is associated with sedation in mice. Metabolites of propanidid analogues currently in development may similarly modulate GABAA, and impaired elimination of these metabolites could produce clinically relevant neurophysiologic effects.

Reactive Separation Processes

2019 ◽  
pp. 1-17
Author(s):  
William A. Leet ◽  
Santi Kulprathipanja
Keyword(s):  
Separation Processes ◽  
Reactive Separation

Experimental and modeling of reactive separation of protocatechuic acid

2018 ◽  
Vol 132 ◽  
pp. 593-605 ◽  
Author(s):  
Biswajit S. De ◽  
Kailas L. Wasewar ◽  
Vicky R. Dhongde ◽  
Anjali A. Ingle ◽  
Himangshu Mondal
Keyword(s):  
Protocatechuic Acid ◽  
Reactive Separation
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