Liquid–Liquid Equilibria in Aqueous Mixtures of Alkylmethylimidazolium Glutamate with Potassium Carbonate and Some Physicochemical Properties of Aqueous [Cnmim][Glu] (n = 4, 6, 8) Solutions

2016 ◽  
Vol 61 (6) ◽  
pp. 2013-2019 ◽  
Author(s):  
Elena V. Alopina ◽  
Evgenia A. Safonova ◽  
Igor B. Pukinsky ◽  
Natalia A. Smirnova
Keyword(s):  
Physicochemical Properties ◽  
Potassium Carbonate ◽  
Aqueous Mixtures

scholarly journals An Ugi Reaction/Intramolecular Cyclization/Oxidation Cascade towards Tetrazole-Linked Dibenzoxazepines

Synthesis ◽  
2021 ◽  
Author(s):  
Alexander Dömling ◽  
Qiang Zheng ◽  
André Boltjes
Keyword(s):  
Physicochemical Properties ◽  
Intramolecular Cyclization ◽  
Potassium Carbonate ◽  
Ugi Reaction ◽  
Short Sequence

AbstractA series of tetrazole-linked dibenzo[b,f][1,4]oxazepines is synthesized through a short sequence involving an Ugi tetrazole reaction. The intermediate tetrazole undergoes a potassium carbonate mediated SNAr cyclization, followed by oxidation to afford the target tricyclic heterocyclic scaffold. The optimization, scope and limitations of this two-step and efficient methodology are investigated. A 1000-member library of tetrazole-linked dibenzo[b,f][1,4]oxazepines is generated and the physicochemical properties are analyzed. great

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