Absorption Kinetics of the Main Conjugated Linoleic Acid Isomers in Commercial-Rich Oil after Oral Administration in Rats

2017 ◽  
Vol 65 (35) ◽  
pp. 7680-7686 ◽  
Author(s):  
Luís M. Rodríguez-Alcalá ◽  
Irma Ares ◽  
Javier Fontecha ◽  
María-Rosa Martínez-Larrañaga ◽  
Arturo Anadón ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Oral Administration ◽  
Conjugated Linoleic Acid ◽  
Absorption Kinetics ◽  
Kinetics Of

scholarly journals Kinetics of trans-10, cis-12-conjugated linoleic acid transfer to plasma and milk following an abomasal bolus in lactating dairy cows

2018 ◽  
Vol 120 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Natalie L. Urrutia ◽  
Monica Toledo ◽  
Michel Baldin ◽  
Jennifer L. Ford ◽  
Michael H. Green ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Milk Fat ◽  
Milk Fat Depression ◽  
Bolus Infusion ◽  
Bioactive Fatty Acids ◽  
Post Infusion ◽  
Kinetics Of ◽  
Transfer To Milk

AbstractTrans-10, cis-12-conjugated linoleic acid (CLA) is a potent bioactive fatty acids (FA) that causes milk fat depression in lactating animals. FA are transferred to milk directly through chylomicrons and indirectly by recycling through other tissues. The objective of this study was to characterise the kinetics of trans-10, cis-12 CLA transfer to plasma and milk after a single bolus infusion. Five multiparous mid-lactation cows received a single abomasal bolus infusion of an enriched CLA mixture providing 15 g of trans-10, cis-12 CLA and 15 g of cis-9, trans-11 CLA over a 30-min period. Plasma concentration of trans-10, cis-12 and cis-9, trans-11 CLA peaked 2 h post-bolus, reaching 0·29 and 0·38 % of total plasma FA, respectively, and returned to pre-bolus values at 72 h post-infusion. Milk trans-10, cis-12 CLA yield and concentration peaked 14 h post-bolus (0·25 g/h) and was not detectable in milk after 86 h. Total apparent transfer of trans-10, cis-12 CLA to milk was 41 %, with 73 % transferred to milk through the direct pool (chylomicrons) and the remaining 27 % transferred through the indirect pool (tissue recycling). Compartmental modelling revealed the existence of a transient unavailable pool of trans-10, cis-12 CLA in extravascular tissues represented primarily by the mammary gland, which slowly exchanges with an available pool for secretion in milk fat and transfer to milk. In conclusion, trans-10, cis-12 CLA is predominantly transferred to milk through the direct pathway; however, how this CLA isomer is processed within the mammary gland requires further investigation.

scholarly journals Absorption kinetics of dihydroergotoxine following oral administration to man.

1985 ◽  
Vol 20 (6) ◽  
pp. 603-609 ◽  
Author(s):  
BG Woodcock ◽  
N. Rietbrock ◽  
W. Loh ◽  
WD Habedank
Keyword(s):  
Oral Administration ◽  
Absorption Kinetics ◽  
Kinetics Of

Absorption Kinetics of Aspirin in Man follow Oral Administration of an Aqueous Solution

1972 ◽  
Vol 61 (3) ◽  
pp. 379-385 ◽  
Author(s):  
Malcolm Rowland ◽  
Sidney Riegelman ◽  
Phillip A. Harris ◽  
Stephen D. Sholkoff
Keyword(s):  
Aqueous Solution ◽  
Oral Administration ◽  
Absorption Kinetics ◽  
Kinetics Of

A single oral administration of conjugated linoleic acid enhanced energy metabolism in mice

Lipids ◽  
2001 ◽  
Vol 36 (6) ◽  
pp. 583-587 ◽  
Author(s):  
Koichiro Ohnuki ◽  
Satoshi Haramizu ◽  
Kasumi Oki ◽  
Kengo Ishihara ◽  
Tohru Fushiki
Keyword(s):  
Linoleic Acid ◽  
Energy Metabolism ◽  
Oral Administration ◽  
Conjugated Linoleic Acid ◽  
Single Oral Administration
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