Apparent Absorption Kinetics of Micronized Griseofulvin after Its Oral Administration on Single‐ and Multiple‐Dose Regimens to Rats as a Corn Oil‐in‐Water Emulsion and Aqueous Suspension

1975 ◽  
Vol 64 (9) ◽  
pp. 1475-1481 ◽  
Author(s):  
Theodore R. Bates ◽  
Philip J. Carrigan
Keyword(s):  
Oral Administration ◽  
Multiple Dose ◽  
Corn Oil ◽  
Aqueous Suspension ◽  
Absorption Kinetics ◽  
Water Emulsion ◽  
Apparent Absorption ◽  
Oil In Water ◽  
Oil In Water Emulsion ◽  
Kinetics Of

Morphology of crosslinked poly(ε-caprolactone) microparticles

2013 ◽  
Vol 1569 ◽  
pp. 173-178
Author(s):  
Fabian Friess ◽  
Andreas Lendlein ◽  
Christian Wischke
Keyword(s):  
Solid State ◽  
Aqueous Suspension ◽  
Polymer Network ◽  
Water Emulsion ◽  
Chain Mobility ◽  
Oil In Water ◽  
Emulsion Process ◽  
Oil In Water Emulsion ◽  
Particle Shapes ◽  
Internal Inhomogeneity

ABSTRACTIn order to explore the feasibility for preparing defined crosslinked particulate structures, oligo(ε-caprolactone) [oCL] derived microparticles (MPs) were crosslinked in non-molten, non-dissolved, i.e. solid state in aqueous suspension by applying a controlled regime with well-defined polymer network precursors either with or without photoinitiator. The MPs (diameter ∼ 40 μm) were prepared by an oil-in-water emulsion process from linear 2oCL or 4-arm star-shaped 4oCL with methacrylate end groups. Crosslinking was initiated by UV-laser irradiation (308 nm) at room temperature. Conversion of methacrylate was monitored by ATR-FTIR spectroscopy and crosslinking was confirmed by a lack of MP dissolution in dichloromethane. In a quantitative evaluation of swelling by dynamic light scattering, higher swelling ratios were detected for particles synthesized with photoinitiator. Wrinkled particle surfaces and distorted particle shapes were observed by light microscopy in the solvent-swollen state and by scanning electron microscopy after deswelling. This work indicated some limitations due to internal inhomogeneity of the MP, but particle crosslinking in solid state was generally possible and may be further improved by higher chain mobility during crosslinking.

Freezing Kinetics of a Model Oil-in-Water Emulsion under High Pressure or by Pressure Release. Impact on Ice Crystals and Oil Droplets

LWT ◽  
1999 ◽  
Vol 32 (7) ◽  
pp. 396-405 ◽  
Author(s):  
Jérôme Lévy ◽  
Eliane Dumay ◽  
Eric Kolodziejczyk ◽  
Jean Claude Cheftel
Keyword(s):  
High Pressure ◽  
Ice Crystals ◽  
Oil Droplets ◽  
Water Emulsion ◽  
Pressure Release ◽  
Oil In Water ◽  
Model Oil ◽  
Oil In Water Emulsion ◽  
Kinetics Of
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