Directed Evolution of Carbonyl Reductase from Rhodosporidium toruloides and Its Application in Stereoselective Synthesis of tert-Butyl (3R,5S)-6-Chloro-3,5-dihydroxyhexanoate

2017 ◽  
Vol 65 (18) ◽  
pp. 3721-3729 ◽  
Author(s):  
Zhi-Qiang Liu ◽  
Lin Wu ◽  
Xiao-Jian Zhang ◽  
Ya-Ping Xue ◽  
Yu-Guo Zheng
Keyword(s):  
Directed Evolution ◽  
Stereoselective Synthesis ◽  
Carbonyl Reductase ◽  
Rhodosporidium Toruloides ◽  
Tert Butyl

Stereoselective Synthesis of Chiral δ-Lactones via an Engineered Carbonyl Reductase

2021 ◽  
Author(s):  
Tao Wang ◽  
Xiaoyan Zhang ◽  
Yucong Zheng ◽  
Yunpeng Bai
Keyword(s):  
Serratia Marcescens ◽  
Directed Evolution ◽  
Stereoselective Synthesis ◽  
Specific Activity ◽  
Carbonyl Reductase

A carbonyl reductase variant, SmCRM5, from Serratia marcescens was obtained through structure-guided directed evolution. The variant showed improved specific activity (U mg-1) toward most of 16 tested substrates and gave...

Biosynthesis of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate by carbonyl reductase from Rhodosporidium toruloides in mono and biphasic media

2018 ◽  
Vol 249 ◽  
pp. 161-167 ◽  
Author(s):  
Zhi-Qiang Liu ◽  
Lin Wu ◽  
Ling Zheng ◽  
Wen-Zhong Wang ◽  
Xiao-Jian Zhang ◽  
...  
Keyword(s):  
Carbonyl Reductase ◽  
Rhodosporidium Toruloides ◽  
Tert Butyl

Stereoselective synthesis of (3S,4S)-tert-butyl-N-Boc-3-ethyl-4-hydroxy-l-prolinate and (3S,4R)-tert-butyl-N-Boc-3-ethyl-4-hydroxy-l-prolinate

Tetrahedron ◽  
2005 ◽  
Vol 61 (15) ◽  
pp. 3725-3731 ◽  
Author(s):  
Pauline Chabaud ◽  
Gérard Pèpe ◽  
Jérôme Courcambeck ◽  
Michel Camplo
Keyword(s):  
Stereoselective Synthesis ◽  
Tert Butyl

Stereoselective synthesis of isoindolinones and tert -butyl sulfoxides

Tetrahedron ◽  
2018 ◽  
Vol 74 (5) ◽  
pp. 578-584 ◽  
Author(s):  
Robert Kawęcki ◽  
Wojciech Stańczyk ◽  
Agnieszka Jaglińska
Keyword(s):  
Stereoselective Synthesis ◽  
Tert Butyl

Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase

2019 ◽  
Vol 2 (10) ◽  
pp. 931-941 ◽  
Author(s):  
Xi Chen ◽  
Hongliu Zhang ◽  
Miguel A. Maria-Solano ◽  
Weidong Liu ◽  
Juan Li ◽  
...  
Keyword(s):  
Directed Evolution ◽  
Carbonyl Reductase

Efficient Stereoselective Synthesis of Structurally Diverse γ‐ and δ‐Lactones Using an Engineered Carbonyl Reductase

ChemCatChem ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2600-2606 ◽  
Author(s):  
Meng Chen ◽  
Xiao‐Yan Zhang ◽  
Chen‐Guang Xing ◽  
Chao Zhang ◽  
Yu‐Cong Zheng ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Carbonyl Reductase
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