Efficient Stereoselective Synthesis of Structurally Diverse γ‐ and δ‐Lactones Using an Engineered Carbonyl Reductase

ChemCatChem ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2600-2606 ◽  
Author(s):  
Meng Chen ◽  
Xiao‐Yan Zhang ◽  
Chen‐Guang Xing ◽  
Chao Zhang ◽  
Yu‐Cong Zheng ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Carbonyl Reductase

Stereoselective Synthesis of Chiral δ-Lactones via an Engineered Carbonyl Reductase

2021 ◽  
Author(s):  
Tao Wang ◽  
Xiaoyan Zhang ◽  
Yucong Zheng ◽  
Yunpeng Bai
Keyword(s):  
Serratia Marcescens ◽  
Directed Evolution ◽  
Stereoselective Synthesis ◽  
Specific Activity ◽  
Carbonyl Reductase

A carbonyl reductase variant, SmCRM5, from Serratia marcescens was obtained through structure-guided directed evolution. The variant showed improved specific activity (U mg-1) toward most of 16 tested substrates and gave...

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