scholarly journals MiR-144 promotes β-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury

Oncotarget ◽  
2017 ◽  
Vol 8 (35) ◽  
pp. 59181-59203 ◽  
Author(s):  
Liqian Sun ◽  
Manman Zhao ◽  
Jingbo Zhang ◽  
Aihua Liu ◽  
Wenjun Ji ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Impairments ◽  
Amyloid Accumulation ◽  
Β Amyloid

Cognitive Functioning Among Individuals With Traumatic Brain Injury, Alzheimer??s Disease, and No Cognitive Impairments

2008 ◽  
Vol 23 (3) ◽  
pp. 149-157 ◽  
Author(s):  
Sabrina Breed ◽  
Amanda Sacks ◽  
Teresa A. Ashman ◽  
Wayne A. Gordon ◽  
Karen Dahlman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Functioning ◽  
Cognitive Impairments

PO266 Targeted treatment for cognitive impairments following traumatic brain injury with methylphenidate

2017 ◽  
Vol 88 (Suppl 1) ◽  
pp. A82.2-A82
Author(s):  
Peter Jenkins ◽  
Sara De Simoni ◽  
Niall Bourke ◽  
James Cole ◽  
David Sharp
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Impairments ◽  
Targeted Treatment

Stratifying drug treatment of cognitive impairments after traumatic brain injury using neuroimaging

Brain ◽  
2019 ◽  
Vol 142 (8) ◽  
pp. 2367-2379 ◽  
Author(s):  
Peter O Jenkins ◽  
Sara De Simoni ◽  
Niall J Bourke ◽  
Jessica Fleminger ◽  
Gregory Scott ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Reaction Time ◽  
Dopamine Transporter ◽  
Choice Reaction Time ◽  
Cognitive Impairments ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Dopaminergic Drugs ◽  
Median Change

Abstract Cognitive impairment is common following traumatic brain injury. Dopaminergic drugs can enhance cognition after traumatic brain injury, but individual responses are highly variable. This may be due to variability in dopaminergic damage between patients. We investigate whether measuring dopamine transporter levels using 123I-ioflupane single-photon emission computed tomography (SPECT) predicts response to methylphenidate, a stimulant with dopaminergic effects. Forty patients with moderate-severe traumatic brain injury and cognitive impairments completed a randomized, double-blind, placebo-controlled, crossover study. 123I-ioflupane SPECT, MRI and neuropsychological testing were performed. Patients received 0.3 mg/kg of methylphenidate or placebo twice a day in 2-week blocks. Subjects received neuropsychological assessment after each block and completed daily home cognitive testing during the trial. The primary outcome measure was change in choice reaction time produced by methylphenidate and its relationship to stratification of patients into groups with normal and low dopamine transporter binding in the caudate. Overall, traumatic brain injury patients showed slow information processing speed. Patients with low caudate dopamine transporter binding showed improvement in response times with methylphenidate compared to placebo [median change = −16 ms; 95% confidence interval (CI): −28 to −3 ms; P = 0.02]. This represents a 27% improvement in the slowing produced by traumatic brain injury. Patients with normal dopamine transporter binding did not improve. Daily home-based choice reaction time results supported this: the low dopamine transporter group improved (median change −19 ms; 95% CI: −23 to −7 ms; P = 0.002) with no change in the normal dopamine transporter group (P = 0.50). The low dopamine transporter group also improved on self-reported and caregiver apathy assessments (P = 0.03 and P = 0.02, respectively). Both groups reported improvements in fatigue (P = 0.03 and P = 0.007). The cognitive effects of methylphenidate after traumatic brain injury were only seen in patients with low caudate dopamine transporter levels. This shows that identifying patients with a hypodopaminergic state after traumatic brain injury can help stratify the choice of cognitive enhancing therapy.

Consequences of cognitive impairments following traumatic brain injury: Pilot study on visual exploration while driving

Brain Injury ◽  
2010 ◽  
Vol 24 (4) ◽  
pp. 678-691 ◽  
Author(s):  
Isabelle Milleville-Pennel ◽  
Johanna Pothier ◽  
Jean-Michel Hoc ◽  
Jean-François Mathé
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Pilot Study ◽  
Cognitive Impairments ◽  
Visual Exploration

scholarly journals The effect of time on cognitive impairments after non-traumatic subarachnoid haemorrhage and after traumatic brain injury

Brain Injury ◽  
2018 ◽  
Vol 32 (12) ◽  
pp. 1465-1476 ◽  
Author(s):  
Anna Tölli ◽  
Charlotte Höybye ◽  
Bo-Michael Bellander ◽  
Fredrik Johansson ◽  
Jörgen Borg
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Subarachnoid Haemorrhage ◽  
Cognitive Impairments ◽  
Traumatic Subarachnoid Haemorrhage
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