Perfluorooctane Sulfonate Plasma Half-Life Determination and Long-Term Tissue Distribution in Beef Cattle (Bos taurus)

2015 ◽  
Vol 63 (51) ◽  
pp. 10988-10994 ◽  
Author(s):  
Sara J. Lupton ◽  
Kerry L. Dearfield ◽  
John J. Johnston ◽  
Sarah Wagner ◽  
Janice K. Huwe
Keyword(s):  
Beef Cattle ◽  
Tissue Distribution ◽  
Half Life ◽  
Bos Taurus ◽  
Perfluorooctane Sulfonate ◽  
Plasma Half Life

scholarly journals Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Akihiro Kikuchi ◽  
Hiroaki Takayama ◽  
Hirohiko Tsugane ◽  
Kazuhiro Shiba ◽  
Keita Chikamoto ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Half Life ◽  
Plasma Half Life

scholarly journals Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution

1991 ◽  
Vol 19 (17) ◽  
pp. 4695-4700 ◽  
Author(s):  
P.Chris de Smidt ◽  
Trung Le Doan ◽  
Sandro de Falco ◽  
Theo J.C.van Berkel
Keyword(s):  
Tissue Distribution ◽  
Half Life ◽  
Antisense Oligonucleotides ◽  
Plasma Half Life

Topical application of a chlordane-containing ectoparasiticide: effect on the plasma half-life of warfarin in dogs

1975 ◽  
Vol 9 (2) ◽  
pp. 135-137 ◽  
Author(s):  
K. A. Bachmann ◽  
A. M. Burkman
Keyword(s):  
Half Life ◽  
Inductive Effect ◽  
Intact Skin ◽  
Metabolizing Enzymes ◽  
Fat Depots ◽  
Long Term Storage ◽  
Plasma Half Life ◽  
Term Storage ◽  
Pharmacologic Study

Brief exposure of dogs to topical chlordane solutions resulted in a significant and long-lasting decrease in the biological half-life of orally administered warfarin. The effect is presumed to be an expression of chlordane's well-documented inductive effect on hepatic microsomal drug metabolizing enzymes and its long-term storage in fat depots. The facility with which chlordane is absorbed through the intact skin of dogs may render casually-treated animals unsuitable for subsequent pharmacologic study for long periods of time.

Distribution and Excretion of Perfluorooctane Sulfonate (PFOS) in Beef Cattle (Bos taurus)

2014 ◽  
Vol 62 (5) ◽  
pp. 1167-1173 ◽  
Author(s):  
Sara J. Lupton ◽  
Janice K. Huwe ◽  
David J. Smith ◽  
Kerry L. Dearfield ◽  
John J. Johnston
Keyword(s):  
Beef Cattle ◽  
Bos Taurus ◽  
Perfluorooctane Sulfonate

Genetic options to replace dehorning in beef cattle—a review

2007 ◽  
Vol 58 (1) ◽  
pp. 1 ◽  
Author(s):  
K. C. Prayaga
Keyword(s):  
Beef Cattle ◽  
Bos Taurus ◽  
Scientific Evidence ◽  
Molecular Genetic ◽  
Chromosome 1 ◽  
Current State ◽  
Large Scope ◽  
Genetic Level ◽  
New Research

Breeding polled cattle is a long-term solution to problems commonly associated with horned cattle. The current practice of dehorning does not eradicate the problem and is an animal-welfare concern. The present study reviews the current state of knowledge on the genetic basis of polled inheritance in cattle. The poll/horn condition is presumed to be under a relatively complex mode of inheritance whereby poll, scur, and African horn genes segregate independently, but interact with each other to produce polled, scurred, and horned animals. Molecular genetic studies have mapped the polled gene to a specific region on bovine chromosome 1 in Bos taurus animals, but the actual gene is still to be located. Scur and African horn genes have not been studied extensively at a molecular genetic level. With the current advances in molecular genetics and statistical methods, there is large scope to undertake new research programs to develop DNA tests that identify homozygous/heterozygous animals for poll, scur, and African horn genes. This would assist faster introgression of the polled condition into beef cattle populations. Existing scientific evidence to counter or support industry perceptions about the production-related issues of the polled condition are presented.

Covalent Complexes Between Low Molecular Weight Heparin Fragments and Antithrombin III – Inhibition Kinetics and Turnover Parameters

1983 ◽  
Vol 49 (02) ◽  
pp. 109-115 ◽  
Author(s):  
M Hoylaerts ◽  
E Holmer ◽  
M de Mol ◽  
D Collen
Keyword(s):  
Molecular Weight ◽  
Half Life ◽  
Low Molecular Weight Heparin ◽  
Antithrombin Iii ◽  
Factor Xa ◽  
Life Time ◽  
Low Molecular Weight ◽  
High Affinity ◽  
Plasma Half Life ◽  
Covalent Complex

SummaryTwo high affinity heparin fragments (A/r 4,300 and M, 3,200) were covalently coupled to antithrombin III (J. Biol. Chem. 1982; 257: 3401-3408) with an apparent 1:1 stoichiometry and a 30-35% yield.The purified covalent complexes inhibited factor Xa with second order rate constants very similar to those obtained for antithrombin III saturated with these heparin fragments and to that obtained for the covalent complex between antithrombin III and native high affinity heparin.The disappearance rates from plasma in rabbits of both low molecular weight heparin fragments and their complexes could adequately be represented by two-compartment mammillary models. The plasma half-life (t'/j) of both low Afr-heparin fragments was approximately 2.4 hr. Covalent coupling of the fragments to antithrombin III increased this half-life about 3.5 fold (t1/2 ≃ 7.7 hr), approaching that of free antithrombin III (t1/2 ≃ 11 ± 0.4 hr) and resulting in a 30fold longer life time of factor Xa inhibitory activity in plasma as compared to that of free intact heparin (t1/2 ≃ 0.25 ± 0.04 hr).

scholarly journals Evaluation of sustained release mineral boluses as a long-term nutrient delivery method for beef cattle

2021 ◽  
pp. 115028
Author(s):  
Tanner J. Carlisle ◽  
Samuel A. Wyffels ◽  
Steve D. Stafford ◽  
Anna R. Taylor ◽  
Megan L. Van Emon ◽  
...  
Keyword(s):  
Beef Cattle ◽  
Sustained Release ◽  
Delivery Method ◽  
Nutrient Delivery

Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O

2004 ◽  
Vol 286 (4) ◽  
pp. E577-E588 ◽  
Author(s):  
A. Strawford ◽  
F. Antelo ◽  
M. Christiansen ◽  
M. K. Hellerstein
Keyword(s):  
Cell Proliferation ◽  
Adipose Tissue ◽  
Half Life ◽  
De Novo ◽  
Human Subjects ◽  
De Novo Lipogenesis ◽  
Gas Chromatography Mass Spectrometry ◽  
Distribution Analysis ◽  
Mass Isotopomer Distribution Analysis

The turnover of adipose tissue components (lipids and cells) and the pathways of adipose lipid deposition have been difficult to measure in humans. We apply here a 2H2O long-term labeling technique for concurrent measurement of adipose-triglyceride (TG) turnover, cell (DNA) proliferation, and de novo lipogenesis (DNL). Healthy subjects drank 2H2O (70 ml/day) for 5-9 wk. Subcutaneous adipose tissue aspirates were taken (gluteal, thigh, and flank depots). Deuterium incorporation into TG glycerol (representing all-source TG synthesis), TG palmitate (representing DNL, by mass isotopomer distribution analysis), and DNA (representing cell proliferation) was measured by gas chromatography-mass spectrometry. Subjects tolerated the protocol well, and body 2H2O enrichments were stable. Mean TG-glycerol fractional synthesis was 0.12 (i.e., 12%) with a range of 0.03-0.32 after 5 wk and 0.20 (range 0.08-0.49) after 9 wk (TG half-life 200-270 days). Label decay measurements 5-8 mo after discontinuing 2H2O gave similar turnover estimates. Net lipolysis (TG turnover) was 50-60 g/day. DNL contribution to adipose-TG was 0.04 after 9 wk, representing ∼20% of newly deposited TG. Cell proliferation was 0.10-0.17 after 9 wk (half-life 240-425 days). In summary, long-term 2H2O administration to human subjects allows measurement of the dynamics of adipose tissue components. Turnover of all elements is slow, and DNL contributes ∼20% of new TG.

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