Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling

2015 ◽  
Vol 63 (26) ◽  
pp. 6001-6008 ◽  
Author(s):  
Hua Sun ◽  
Xiaotong Zhou ◽  
Xingwang Zhang ◽  
Baojian Wu
Keyword(s):  
Multidrug Resistance ◽  
Hela Cells

Inhibitory role of oleanolic acid and esculetin in HeLa cells involve multiple signaling pathways

Gene ◽  
2021 ◽  
Vol 771 ◽  
pp. 145370
Author(s):  
Prajitha Mohandas Edathara ◽  
Shivakanth Chintalapally ◽  
Venkata Krishna Kanth Makani ◽  
Chitrakshi Pant ◽  
Suresh Yerramsetty ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Hela Cells ◽  
Inhibitory Role ◽  
Multiple Signaling

scholarly journals Reversal Effects of Antifungal Drugs on Multidrug Resistance in MDR1-Overexpressing HeLa Cells

2001 ◽  
Vol 24 (9) ◽  
pp. 1032-1036 ◽  
Author(s):  
Nami IIDA ◽  
Kohji TAKARA ◽  
Nobuko OHMOTO ◽  
Tsutomu NAKAMURA ◽  
Takashi KIMURA ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Hela Cells ◽  
Antifungal Drugs

Possible Role of Phosphoinositide-3-Kinase in Mx1 Protein Translation and Antiviral Activity of Interferon-Omega-Stimulated HeLa Cells

Pharmacology ◽  
2011 ◽  
Vol 87 (3-4) ◽  
pp. 224-231 ◽  
Author(s):  
Youngjun Seo ◽  
Mihee Kim ◽  
Minjoung Choi ◽  
Sunhee Kim ◽  
Kidae Park ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Hela Cells ◽  
Protein Translation ◽  
Phosphoinositide 3 Kinase

scholarly journals An essential role of Cdc42-like GTPases in mitosis of HeLa cells

FEBS Letters ◽  
2006 ◽  
Vol 580 (14) ◽  
pp. 3375-3380 ◽  
Author(s):  
Shingo Yasuda ◽  
Hiroyuki Taniguchi ◽  
Fabian Oceguera-Yanez ◽  
Yoshikazu Ando ◽  
Sadanori Watanabe ◽  
...  
Keyword(s):  
Hela Cells ◽  
Essential Role

scholarly journals Role of anacrRmutation in multidrug resistance ofin vitro-selected fluoroquinolone-resistant mutants ofSalmonella entericaserovar Typhimurium

2004 ◽  
Vol 238 (1) ◽  
pp. 267-272 ◽  
Author(s):  
Anne Olliver ◽  
Michel Vallé ◽  
Elisabeth Chaslus-Dancla ◽  
Axel Cloeckaert
Keyword(s):  
Multidrug Resistance ◽  
Resistant Mutants

The role of the membrane-spanning domain and stalk region of N-acetylglucosaminyltransferase I in retention, kin recognition and structural maintenance of the Golgi apparatus in HeLa cells

1996 ◽  
Vol 109 (7) ◽  
pp. 1975-1989 ◽  
Author(s):  
T. Nilsson ◽  
C. Rabouille ◽  
N. Hui ◽  
R. Watson ◽  
G. Warren
Keyword(s):  
Golgi Apparatus ◽  
Cell Lines ◽  
Hela Cells ◽  
Kin Recognition ◽  
Dramatic Effect ◽  
Golgi Stack ◽  
Stable Cell Lines ◽  
Membrane Spanning ◽  
Necessary And Sufficient

Using a series of chimeric and truncated N-acetylglucosaminyltransferase I (NAGT I) molecules we have shown that part of the lumenal stalk region is both necessary and sufficient for kin recognition of mannosidase II and retention in the Golgi stack. The membrane-spanning domain was not required for retention, but replacing part or all of this domain with leucine residues did have a dramatic effect on Golgi morphology. In stable cell lines, stacked cisternae were replaced by tubulo-vesicular clusters containing the mutated NAGT I. The loss of stacked cisternae was proportional to the number of leucines used to replace the membrane-spanning domain.

scholarly journals The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Carolina Soekmadji ◽  
Colleen C. Nelson
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Advanced Prostate Cancer ◽  
Control Cell ◽  
Extracellular Vesicle ◽  
Multidrug Resistance Proteins ◽  
Acquired Drug Resistance ◽  
Resistance Proteins

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

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