Consumption of Interesterified Medium- and Long-Chain Triacylglycerols Improves Lipid Metabolism and Reduces Inflammation in High-Fat Diet-Induced Obese Rats

2020 ◽  
Vol 68 (31) ◽  
pp. 8255-8262 ◽  
Author(s):  
Ying-Xue Du ◽  
Sun-Ni Chen ◽  
Hong-Lin Zhu ◽  
Xian Niu ◽  
Jing Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats ◽  
Long Chain

scholarly journals Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Lin-Lin Xie ◽  
Yu-Li Zhao ◽  
Jian Yang ◽  
Hui Cheng ◽  
Zhen-Dong Zhong ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Joint Inflammation ◽  
Protective Effects ◽  
High Fat ◽  
Lipid Metabolism Disorder ◽  
Metabolism Disorder ◽  
Obese Rats

The effects of acupuncture on osteoarthritis (OA) pathogenesis have been demonstrated in vitro and in animal models. However, the potential for acupuncture to mediate protective effects on obese-induced OA has not been examined. Here, we investigated the effects of different acupuncture patterns on OA pathogenesis in high-fat diet- (HFD-) induced obese rats. After 12-week diet-induced obesity, obese rats were treated with three acupuncture protocols for 2 weeks, including ST36, GB34, and ST36+GB34. The results showed that the three acupuncture protocols both prevented obesity-induced cartilage matrix degradation and MMP expression and mitigated obesity-induced systemic and local inflammation but had different regulatory effects on lipid metabolism and gut microbiota disorder of obese-induced OA rats. Furthermore, the three acupuncture protocols increased the microbial diversity and altered the structure of community of feces in obese rats. We found that ST36 and GB34 could inhibit proinflammatory shift in the gut microbiome with an increase in the ratio of Bacteroidetes/Firmicutes and promote the recovery of relative abundance of Clostridium, Akkermansia, Butyricimonas, and Lactococcus. Although both ST36 and GB34 had an anti-inflammatory effect on serum inflammatory mediators, only the acupuncture protocol with both ST36 and GB34 could effectively inhibit LPS-mediated joint inflammation in obesity rats. Therefore, relieving obesity-related chronic inflammation, lipid metabolism disorder, and gut microbiota disorder may be an important mechanism for acupuncture with ST36 and GB34 to promote OA recovery.

High-Fat Diet Elevates Liver Docosahexaenoic Acid Possibly through Over-Expression of Very Long-Chain Fatty Acid Elongase 2 in C57BL/6J Mice

2019 ◽  
Vol 89 (1-2) ◽  
pp. 62-72
Author(s):  
Mooli Raja Gopal Reddy ◽  
Gundluri Venkata Asha ◽  
Sravan Kumar Manchiryala ◽  
Uday Kumar Putcha ◽  
Ayyalasomayajula Vajreswari ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Chain Fatty Acid ◽  
High Fat ◽  
Long Chain Fatty Acid ◽  
Fatty Acid Elongase ◽  
Over Expression ◽  
Long Chain

Abstract. The liver is the main site of lipid metabolism and vitamin A storage. Dietary factors are known to affect liver function, thereby leading to metabolic abnormalities. Here, we assessed the impact of long-term feeding of a high-fat diet on hepatic vitamin A status and lipid metabolism. For this purpose, 14 male and 14 female 35-day-old mice (strain C57BL/6J) were each divided into 2 groups of 7 animals and fed either a stock diet or a high-fat (HF) diet for 26 weeks. In addition to increased body weight/weight gain, the HF diet induced hypertriglyceridemia in both (p < 0.01). However, liver triglyceride levels were comparable among groups, which could be partly explained by unaltered expression of various lipogenic pathway proteins such as sterol regulatory element binding protein 1 (SREBP1), fatty acid synthase (FAS), microsomal triglyceride transfer protein (MTTP), and glycerol 3-phosphate acyl transferase (GPAT). On the other hand, hepatic retinol stores increased significantly in both sexes, whereas males displayed elevated circulatory retinol levels. Notably, long-term feeding of a HF diet elevated n-3 polyunsaturated fatty acid (PUFA) and docosahexaenoic acid (DHA, C22:6) levels in the liver (p ≤ 0.001), which is in line with the over-expression of very long-chain fatty acid elongase 2 (ELOVL2) protein in both sexes of mice (p < 0.01). In conclusion, very long-term feeding of a HF diet increased hepatic retinol stores and induced hypertriglyceridemia. However, it had no effect on hepatic triglyceride accumulation, possibly due to increased DHA levels arising from the ELOVL2-mediated elongation pathway.

scholarly journals Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats

Marine Drugs ◽  
2017 ◽  
Vol 15 (12) ◽  
pp. 386
Author(s):  
Wei-Tang Chang ◽  
Tsung-Yueh Lu ◽  
Ming-Ching Cheng ◽  
Hsun-Chi Lu ◽  
Mei-Fang Wu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fatty Acid Oxidation ◽  
Deep Sea ◽  
High Fat Diet ◽  
Sea Water ◽  
Acid Oxidation ◽  
High Fat ◽  
Deep Sea Water ◽  
Obese Rats

Chitosan oligosaccharide ameliorated obesity by reducing endoplasmic reticulum stress in diet-induced obese rats

2020 ◽  
Vol 11 (7) ◽  
pp. 6285-6296 ◽  
Author(s):  
Xiaoyi Deng ◽  
Zhijun Ye ◽  
Hua Cao ◽  
Yan Bai ◽  
Qishi Che ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Lipid Metabolism ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Chitosan Oligosaccharide ◽  
High Fat ◽  
Chitosan Oligosaccharides ◽  
Obese Rats

Chitosan oligosaccharides can alleviate liver endoplasmic reticulum stress to improve lipid metabolism and reduce obesity caused by high-fat diet.

Kefir Peptides Prevent Hyperlipidemia and Obesity in High-Fat-Diet-Induced Obese Rats via Lipid Metabolism Modulation

2018 ◽  
Vol 62 (3) ◽  
pp. 1700505 ◽  
Author(s):  
Yu-Tang Tung ◽  
Hsiao-Ling Chen ◽  
Hsin-Shan Wu ◽  
Mei-Hsuan Ho ◽  
Kowit-Yu Chong ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats
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