Kefir Peptides Prevent Hyperlipidemia and Obesity in High-Fat-Diet-Induced Obese Rats via Lipid Metabolism Modulation

2018 ◽  
Vol 62 (3) ◽  
pp. 1700505 ◽  
Author(s):  
Yu-Tang Tung ◽  
Hsiao-Ling Chen ◽  
Hsin-Shan Wu ◽  
Mei-Hsuan Ho ◽  
Kowit-Yu Chong ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

scholarly journals Electroacupuncture Prevents Osteoarthritis of High-Fat Diet-Induced Obese Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Lin-Lin Xie ◽  
Yu-Li Zhao ◽  
Jian Yang ◽  
Hui Cheng ◽  
Zhen-Dong Zhong ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Joint Inflammation ◽  
Protective Effects ◽  
High Fat ◽  
Lipid Metabolism Disorder ◽  
Metabolism Disorder ◽  
Obese Rats

The effects of acupuncture on osteoarthritis (OA) pathogenesis have been demonstrated in vitro and in animal models. However, the potential for acupuncture to mediate protective effects on obese-induced OA has not been examined. Here, we investigated the effects of different acupuncture patterns on OA pathogenesis in high-fat diet- (HFD-) induced obese rats. After 12-week diet-induced obesity, obese rats were treated with three acupuncture protocols for 2 weeks, including ST36, GB34, and ST36+GB34. The results showed that the three acupuncture protocols both prevented obesity-induced cartilage matrix degradation and MMP expression and mitigated obesity-induced systemic and local inflammation but had different regulatory effects on lipid metabolism and gut microbiota disorder of obese-induced OA rats. Furthermore, the three acupuncture protocols increased the microbial diversity and altered the structure of community of feces in obese rats. We found that ST36 and GB34 could inhibit proinflammatory shift in the gut microbiome with an increase in the ratio of Bacteroidetes/Firmicutes and promote the recovery of relative abundance of Clostridium, Akkermansia, Butyricimonas, and Lactococcus. Although both ST36 and GB34 had an anti-inflammatory effect on serum inflammatory mediators, only the acupuncture protocol with both ST36 and GB34 could effectively inhibit LPS-mediated joint inflammation in obesity rats. Therefore, relieving obesity-related chronic inflammation, lipid metabolism disorder, and gut microbiota disorder may be an important mechanism for acupuncture with ST36 and GB34 to promote OA recovery.

scholarly journals Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats

Marine Drugs ◽  
2017 ◽  
Vol 15 (12) ◽  
pp. 386
Author(s):  
Wei-Tang Chang ◽  
Tsung-Yueh Lu ◽  
Ming-Ching Cheng ◽  
Hsun-Chi Lu ◽  
Mei-Fang Wu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fatty Acid Oxidation ◽  
Deep Sea ◽  
High Fat Diet ◽  
Sea Water ◽  
Acid Oxidation ◽  
High Fat ◽  
Deep Sea Water ◽  
Obese Rats

Chitosan oligosaccharide ameliorated obesity by reducing endoplasmic reticulum stress in diet-induced obese rats

2020 ◽  
Vol 11 (7) ◽  
pp. 6285-6296 ◽  
Author(s):  
Xiaoyi Deng ◽  
Zhijun Ye ◽  
Hua Cao ◽  
Yan Bai ◽  
Qishi Che ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Lipid Metabolism ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Chitosan Oligosaccharide ◽  
High Fat ◽  
Chitosan Oligosaccharides ◽  
Obese Rats

Chitosan oligosaccharides can alleviate liver endoplasmic reticulum stress to improve lipid metabolism and reduce obesity caused by high-fat diet.

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