Identification of Peptides Potentially Responsible for In Vivo Hypolipidemic Activity of a Hydrolysate from Olive Seeds

2020 ◽  
Vol 68 (14) ◽  
pp. 4237-4244 ◽  
Author(s):  
Isabel M. Prados ◽  
J. M. Orellana ◽  
M. Luisa Marina ◽  
M. Concepción García
Keyword(s):  
Hypolipidemic Activity ◽  
Olive Seeds

scholarly journals Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract ofCuratella americanaL. Leaves

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Rafael Henrique Oliveira Lopes ◽  
Luis Fernando Benitez Macorini ◽  
Katia Ávila Antunes ◽  
Priscilla Pereira de Toledo Espindola ◽  
Tamaeh Monteiro Alfredo ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
The Body ◽  
Hypolipidemic Activity ◽  
Key Factors ◽  
High Fructose ◽  
Scavenging Capacity ◽  
Dpph Scavenging ◽  
Hydroethanolic Extract ◽  
Positive Controls

High levels of reactive oxygen species in the body and hyperlipidemia are key factors for the development of cardiovascular diseases such as atherosclerosis. The present study investigated the antioxidant and hypolipidemic activity of hydroethanolic extract ofCuratella americanaL. leaves (ExC). The antioxidant activity of ExC was assessed by 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging capacity and protection against hemolysis induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH), followed by quantification of malondialdehyde (MDA). Wistar rats with hyperlipidemia induced by high-fructose diet (60%) were treated for 60 days with water, simvastatin (30 mg·Kg−1), ciprofibrate (2 mg·Kg−1), and ExC (200 mg·Kg−1). ExC revealed IC50of6.0±0.5 μg·mL−1, an intermediary value among positive controls used in the assay of DPPH scavenging capacity. At all concentrations (50 to 125 μg·mL−1) and times (60 to 240 min) evaluated, ExC protected erythrocytes against AAPH-induced hemolysis, which was confirmed by lower MDA levels.In vivotests showed a reduction of 34 and 45%, respectively, in serum concentration of cholesterol and triglycerides in hyperlipidemic rats treated with ExC, a similar effect compared to the reference drugs, simvastatin and ciprofibrate, respectively. Together, the results showed the antioxidant activity of ExC and its ability to improve the serum lipid profile in hyperlipidemic rats.

Synthesis of some novel substituted phenylisoxazol phenoxy 2-methylpropanoic acids and there in vivo hypolipidemic activity

2016 ◽  
Vol 25 (3) ◽  
pp. 422-428 ◽  
Author(s):  
Santosh N. Mokale ◽  
Pritam N. Dube ◽  
Manjusha C. Nevase ◽  
Nikhil S. Sakle ◽  
Vishakha R. Shelke ◽  
...  
Keyword(s):  
Hypolipidemic Activity

scholarly journals Biological Evaluation ofPupalia lappaceafor Antidiabetic, Antiadipogenic, and Hypolipidemic Activity BothIn VitroandIn Vivo

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Vivek Kumar ◽  
Parag Jain ◽  
Kalpana Rathore ◽  
Zabeer Ahmed
Keyword(s):  
Cell Line ◽  
Reference Group ◽  
Lipid Level ◽  
Biological Evaluation ◽  
Diabetic Rats ◽  
Hypolipidemic Activity ◽  
Albino Rats ◽  
Reference Drug

Objective. The present study assesses the effect ofPupalia lappacea(L.) Juss. (Amaranthaceae) (PL) leaves ethanolic extract on adipocytes, blood glucose level, and lipid level in streptozotocin (STZ) induced diabetic rats.Materials and Methods. Male Albino rats were rendered diabetic by a single moderately sized dose of STZ (45 mg/kg, intraperitoneally) at once before starting the treatment. Animals were divided into five groups: normoglycemic control, diabetic control, reference group (glibenclamide, 5.0 mg/kg), AS001 (250 mg/kg extract), and AS002 (500 mg/kg extract) each containing six animals forin vivostudy. Antidiabetic and hypolipidemic activity of extract were determined byin vivomethod on STZ induced diabetic rats. Antiadipogenic activity was determined byin vitromethod on 3T3-L1 cell line in comparison to simvastatin as reference drug.Result. The extract showed significant fall in fasting serum glucose (FSG), that is, 234.68 and 211.61 mg/dL, in STZ induced diabetic animals for dose groups AS001 and AS002, respectively. ThePLextract also exhibited noteworthy antiadipogenic activity on 3T3-L1 cell line. The value of inhibitory concentration (IC50) ofPLextract to reduce adipocyte cells was found to be 662.14 μg/mL.Conclusion. ThePLextract exhibited significant antiadipogenic, antidiabetic, and hypolipidemic activities.

scholarly journals The Pharmacological Activities of the Metabolites of N-[(Trimethylamineboryl)-Carbonyl]-L-Phenylalanine Methyl Ester

1996 ◽  
Vol 3 (5) ◽  
pp. 219-226 ◽  
Author(s):  
M. C. Miller ◽  
A. Sood ◽  
B. F. Spielvogel ◽  
R. P. Shrewsbury ◽  
I. H. Hall
Keyword(s):  
Methyl Ester ◽  
Parent Compound ◽  
Hypolipidemic Activity ◽  
Significant Activity ◽  
Male Mice ◽  
Anti Inflammatory ◽  
Foot Pad ◽  
Phenylalanine Methyl Ester ◽  
Better Than

The metabolites of N-[(trimethylamineboryl)-carbonyl]-L-phenylalanine methyl ester 1 proved to be active in a number of pharmacological screens where the parent had previously demonstrated potent activity. The proposed metabolites demonstrated significant activity as cytotoxic, hypolipidemic, and anti-inflammatory agents. In cytotoxicity screens several of the proposed metabolites afforded better activity than the parent compound against the growth of suspended and solid tumor cell lines. Evaluation of in vivo hypolipidemic activity demonstrated that the proposed metabolites of 1 were only moderately active and were generally less effective than the parent compound. Interestingly, L-phenylalanine methyl ester hydrochloride 3, which contains no boron atom, demonstrated equivalent hypolipidemic activity as the parent at 8 mg/kg/day in CF1 male mice. As anti-inflammatory agents the proposed metabolites demonstrated variable capacities to reduce foot pad inflammation. These compounds were similarly effective as the parent 1 at blocking local pain and were generally better than the parent at protecting CF1 male mice from LPS induced sepsis.

Molecular Characterization of Novel and Selective Peroxisome Proliferator-Activated Receptor α Agonists with Robust Hypolipidemic Activity in Vivo

2008 ◽  
Vol 75 (2) ◽  
pp. 296-306 ◽  
Author(s):  
Christopher D. Kane ◽  
Kimberly A. Stevens ◽  
James E. Fischer ◽  
Mehrdad Haghpassand ◽  
Lori J. Royer ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Hypolipidemic Activity ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

Synthesis and in-vivo hypolipidemic activity of some novel substituted phenyl isoxazol phenoxy acetic acid derivatives

2014 ◽  
Vol 24 (9) ◽  
pp. 2155-2158 ◽  
Author(s):  
Santosh N. Mokale ◽  
Manjusha C. Nevase ◽  
Nikhil S. Sakle ◽  
Pritam N. Dube ◽  
Vishakha R. Shelke ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Hypolipidemic Activity ◽  
Phenoxy Acetic Acid

scholarly journals Evaluation of in vivo Synergistic Hypoglycemic & Hypolipidemic Activity of Ethanolic Extract of Calotropis gigantean Leaves in Combination to Metformin in Alloxan Induced Rats

2019 ◽  
pp. 1-10
Author(s):  
Nisrat Jahan ◽  
Nasreen Akter ◽  
Mosiqur Rahman
Keyword(s):  
Body Weight ◽  
Combination Therapy ◽  
Plant Extract ◽  
Leaf Extract ◽  
Liver Weight ◽  
Diabetic Rats ◽  
Hypolipidemic Activity ◽  
Control Group ◽  
Ethanolic Leaf Extract

Aim: The present study was designed to investigate the antidiabetic & hypolipidemic activity of Calotropis gigantean (Family: Apocynaceae) in alloxan-induced diabetic rat model. Study Design: In vivo study was carried out by ethanolic leaf extract was administered in 250 mg/kg body weight concentration and then subjected to different rats models to authenticate the antidiabetic and hyperlipidimic properties of the plant. Place and Duration of Study: Department of Pharmacy, Southeast University, Banani, Dhaka-1213,Bangladesh within a period of July 2018 to December, 2018. Methodology: Diabetes was induced in rats by an intraperitoneal injection (i.p) of alloxan (100 mg/kg B.W). Ethanolic leaf extract of C. gigantean (250 mg/kg B.W) was administrated orally as a single dose per day to the diabetic rats for 7 days. The negative control group received 0.5 ml of sterile normal saline water orally & positive control group received metformin orally. Synergistic effect of plant was evaluated by combination with 100 mg/kg B.W & 50 mg/kg B.W oral administration of metformin. After 7 days study period, fasting blood glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol, liver weight & body weight were measured only for diabetic group to observe the effects of diabetes induction. Results: Individual plant extract (250 mg/Kg B.W) & Metformin (100 mg/kg B.W) reduced FBG significantly by 52% (P<0.001) & 55.3% (P<0.001) correspondingly. Metformin (100 mg/kg B.W) potentiated reduction (68%) (P<0.001) when combined to plant extract (250 mg/Kg B.W). Significant dose dependent manner was followed when metformin (50 mg/kg B.W) was combined to plant extract (250 mg/Kg B.W). Our results clearly suggests that C. gigantean exhibit hypoglycemic & hypolipidemic activity with an alteration in body-liver weight. The present study also suggested to develop a combination therapy of extract along with metfromin in different doses to minimize the intake of synthetic drug. Significant reduction of TG, TC were noted by extract (250 mg/kg B.W) with 32.42% (P<0.001) & 41.32% (P<0.001) respectively where standard shown the diminution 43.43% (P<0.05) & 47.21% (P<0.001) respectively as compare to Untreated diabetic rats. 50.21% (P<0.01) & 42.38% (P<0.001) reduction of TG & TC were estimated by C.gigantea extracts (250 mg/kg B.W) when combined with Metformin (100 mg/kg B.W). 34.53% (P<0.05) & 41.54% (P<0.001) reduction of TG & TC by C.gigantea extracts (250 mg/kg B.W) were confirmed when combined to Metformin (50 mg/kg B.W). Combination therapy also has shown synergistic effect in elevation of plasma HDL-cholesterol. Conclusion: The results of the study concluded that C. gigantean have potential antidiabetic and antioxidant properties.

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