scholarly journals Time Trends in Per- and Polyfluoroalkyl Substances (PFASs) in California Women: Declining Serum Levels, 2011–2015

2017 ◽  
Vol 52 (1) ◽  
pp. 277-287 ◽  
Author(s):  
Susan Hurley ◽  
Debbie Goldberg ◽  
Miaomiao Wang ◽  
June-Soo Park ◽  
Myrto Petreas ◽  
...  
Keyword(s):  
Time Trends ◽  
Serum Levels ◽  
Polyfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances in Landfill Leachate: Patterns, Time Trends, and Sources

2012 ◽  
Vol 46 (21) ◽  
pp. 11532-11540 ◽  
Author(s):  
Jonathan P. Benskin ◽  
Belinda Li ◽  
Michael G. Ikonomou ◽  
John R. Grace ◽  
Loretta Y. Li
Keyword(s):  
Landfill Leachate ◽  
Time Trends ◽  
Polyfluoroalkyl Substances

scholarly journals Per- and polyfluoroalkyl substances (PFASs) in Swedish household dust and exposure of pet cats

2021 ◽  
Author(s):  
Jana M. Weiss ◽  
Bernt Jones ◽  
Jacco Koekkoek ◽  
Anders Bignert ◽  
Marja H. Lamoree
Keyword(s):  
Thyroid Hormone ◽  
Solid Phase ◽  
Serum Levels ◽  
Mass Spectrometry Analysis ◽  
Household Dust ◽  
Serum Samples ◽  
Spectrometry Analysis ◽  
Exposure Pathway ◽  
Wide Range ◽  
Polyfluoroalkyl Substances

AbstractPer- and polyfluoroalkyl substances (PFASs) are used in a wide range of products and have been found ubiquitously in our indoor environment, and there is evidence that exposure to PFAS can lead to adverse endocrine effects, such as thyroid hormone disruption. Pet cats have a high dust intake due to their grooming behavior and have been shown to be a suitable sentinel species for assessment of toddler’s exposure. Here we used paired household dust (n=46) and cat serum (n=27) samples to establish whether dust is a relevant exposure pathway to PFASs. An analytical method for PFAS analysis was optimized using a low volume of cat serum samples, combining solid-phase extraction and online sample cleanup. Dust was extracted with methanol by sonication and cleaned up by addition of active carbon. In total, 27 PFASs were analyzed by liquid chromatography/mass spectrometry analysis. The correlation between PFAS levels in dust and serum, serum lipids and thyroid hormone levels, and PFAS levels in dust between different rooms were statistically evaluated. PFOS and PFDA could be quantified in all cat serum samples (median 2300 pg/mL and 430 pg/mL, respectively), followed by PFOA (median 1100 pg/mL), quantified in 96% of the samples. The levels of 6:2 and 8:2 diPAPs were determined in 65% and 92% of the serum samples, respectively, and were an order of magnitude lower (1.4–160 pg/mL). Household dust on the other hand was dominated by 6:2 and 8:2 diPAPs, with a median of 65 ng/g dust and 49 ng/g dust, respectively. PFOS (median 13 ng/g dust) and PFOA (median 9 ng/g dust) were quantified in 93% of the dust samples. Only eight PFASs were detected (>LOD) in at least 50% of the samples of both matrices and could be paired. Significant correlations between cat serum and dust were found for PFOA (rS=0.32, p<0.049) and PFUnDA (rS=0.55, p<0.001). Significant positive correlations were found between serum total thyroxine (rS=0.11, p<0.05) and PFNA and between serum cholesterol and PFHpA (rS=0.46, p<0.01), PFUnDA (rS=0.40, p<0.05), PFDoDA (rS=0.44, p<0.01), and sum PFAS (rS=0.48, p<0.01). In conclusion, this study confirmed that dust is a relevant exposure pathway for the ingestion of some PFASs for cats, and the serum levels of PFASs could be of relevance for the cat’s health.

scholarly journals Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women

2020 ◽  
Vol 17 (2) ◽  
pp. 606
Author(s):  
Eunjung Lee ◽  
April Kinninger ◽  
Giske Ursin ◽  
Chiuchen Tseng ◽  
Susan Hurley ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Mammographic Density ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Polybrominated Diphenyl Ethers ◽  
Multiple Testing ◽  
Serum Levels ◽  
P Value ◽  
Polyfluoroalkyl Substances ◽  
The Impact

There are little epidemiological data on the impact of persistent organic pollutants (POPs) and endocrine disruptors on mammographic density (MD), a strong predictor of breast cancer. We assessed MD in 116 non-Hispanic white post-menopausal women for whom serum concentrations of 23 commonly detected chemicals including 3 polybrominated diphenyl ethers (PBDEs), 8 per- and polyfluoroalkyl substances (PFASs), and 12 polychlorinated biphenyls (PCBs) had been measured. Linear regression analyses adjusting for potential confounders were used to examine the associations between the levels of the chemical compounds, modeled as continuous and dichotomized (above/below median) variables, and square-root-transformed MD. None of the associations were statistically significant after correcting for multiple testing. Prior to correction for multiple testing, all chemicals with un-corrected p-values < 0.05 had regression coefficients less than zero, suggesting inverse associations between increased levels and MD, if any. The smallest p-value was observed for PCB-153 (regression coefficient for above-median vs. below-median levels: −0.87, un-corrected p = 0.008). Neither parity nor body mass index modified the associations. Our results do not support an association between higher MD and serum levels of PBDEs, PCBs, or PFASs commonly detected in postmenopausal women.

scholarly journals Intra-individual variations and time trends 1991–2001 in human serum levels of PCB, DDE and hexachlorobenzene

Chemosphere ◽  
2006 ◽  
Vol 64 (9) ◽  
pp. 1507-1513 ◽  
Author(s):  
Lars Hagmar ◽  
Ewa Wallin ◽  
Bengt Vessby ◽  
Bo AG Jönsson ◽  
Åke Bergman ◽  
...  
Keyword(s):  
Human Serum ◽  
Time Trends ◽  
Serum Levels ◽  
Individual Variations

scholarly journals Prevalence and Predictors of Per- and Polyfluoroalkyl Substances (PFAS) Serum Levels among Members of a Suburban US Volunteer Fire Department

2021 ◽  
Vol 18 (7) ◽  
pp. 3730
Author(s):  
Judith M. Graber ◽  
Taylor M. Black ◽  
Nimit N. Shah ◽  
Alberto J. Caban-Martinez ◽  
Shou-en Lu ◽  
...  
Keyword(s):  
Fire Department ◽  
Serum Levels ◽  
Geometric Means ◽  
Adverse Health Outcomes ◽  
Health And Nutrition ◽  
Perfluorodecanoic Acid ◽  
Polyfluoroalkyl Substances ◽  
Volunteer Firefighters ◽  
Study Participants ◽  
Future Work

Background: Per-and polyfluoroalkyl substances (PFAS), are ubiquitous pollutants associated with adverse health outcomes. High PFAS levels have been demonstrated among career firefighters; less is known about PFAS levels among volunteer firefighters who comprise two-thirds of US firefighters. Methods: Volunteer fire department members completed a survey and provided blood samples. We calculated geometric means and 95% CIs for PFAS reported by the National Health and Nutrition Examination Survey (NHANES). We compared PFAS distribution and levels among non-Hispanic white adult male study participants to those in the 2015–2016 and 2017–2018 NHANES cycles. We assessed associations between PFAS serum levels and years of firefighting controlling demographics and occupation using linear regression. Results: Participant’s average age was 46.6 years (sd. 17.1). Perfluorododecanoic acid (PFDoA) was detected in almost half study but <3% of NHANES participants; serum levels of PFDoA, perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were elevated among participants compared with NHANES. Serum levels of both PFDA and PFDoA were positively associated with years of firefighting. Conclusions: Volunteer firefighters may have a different serum profile and levels of PFAS than the general population. Future work in this area should include volunteer firefighters from other geographic locations and assess sources of PFAS exposure.

scholarly journals Per- and polyfluoroalkyl substances (PFAS) and non-fasting total cholesterol serum levels among New Jersey volunteer firefighters

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Patricia A. Amarilla ◽  
Zorimar Rivera Nunez ◽  
Nimit N. Shah ◽  
Jefferey L. Burgess ◽  
Taylor Black ◽  
...  
Keyword(s):  
New Jersey ◽  
Total Cholesterol ◽  
Serum Levels ◽  
Polyfluoroalkyl Substances ◽  
Volunteer Firefighters

Serum levels of per- and polyfluoroalkyl substances alternatives and blood pressure by sex status: Isomers of C8 health project in China

Chemosphere ◽  
2020 ◽  
Vol 261 ◽  
pp. 127691
Author(s):  
Xin Mi ◽  
Yun-Qing Yang ◽  
Mohammed Zeeshan ◽  
Zhi-Bin Wang ◽  
Xiao-Yun Zeng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Serum Levels ◽  
Health Project ◽  
Polyfluoroalkyl Substances

Nucleolar Segregation and Chronic Methanol Intoxication

1969 ◽  
Vol 27 ◽  
pp. 360-361
Author(s):  
Julio H. Garcia ◽  
Janice P. Van Zandt
Keyword(s):  
Body Weight ◽  
Methyl Alcohol ◽  
Rhesus Monkeys ◽  
Repeated Administration ◽  
Serum Levels ◽  
Methanol Intoxication ◽  
Intragastric Tube ◽  
Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

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