Continuous Spherical Crystallization of Lysozyme in an Oscillatory Baffled Crystallizer Using Emulsion Solvent Diffusion in Droplets

2020 ◽  
Vol 20 (2) ◽  
pp. 934-947 ◽  
Author(s):  
Joseph A. Oliva ◽  
Wei-Lee Wu ◽  
Michael R. Greene ◽  
Kanjakha Pal ◽  
Zoltan K. Nagy
Keyword(s):  
Solvent Diffusion ◽  
Spherical Crystallization

scholarly journals Spherical crystallization of drugs

2012 ◽  
Vol 62 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Borut Kovačič ◽  
Franc Vrečer ◽  
Odon Planinšek
Keyword(s):  
Mechanical Properties ◽  
Process Parameters ◽  
Physical And Mechanical Properties ◽  
Spherical Particles ◽  
Direct Compression ◽  
Solvent Diffusion ◽  
Spherical Crystallization ◽  
Stirring Rate ◽  
Diffusion Systems ◽  
Rate Type

Spherical crystallization of drugs Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.

Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion

2020 ◽  
Vol 17 (4) ◽  
pp. 1387-1396 ◽  
Author(s):  
Hongbo Chen ◽  
Shubhajit Paul ◽  
Hongyun Xu ◽  
Kunlin Wang ◽  
Mahesh K. Mahanthappa ◽  
...  
Keyword(s):  
Solvent Diffusion ◽  
Spherical Crystallization

scholarly journals Spherical Crystallization: Modeling of the Emulsion Solvent Diffusion Technique

1997 ◽  
Vol 15 (0) ◽  
pp. 159-169
Author(s):  
Fabienne Espitalier ◽  
Béatrice Biscans ◽  
Claude Laguerie ◽  
Michel Deleuil
Keyword(s):  
Solvent Diffusion ◽  
Spherical Crystallization ◽  
Diffusion Technique

Micromeritic characteristics and agglomeration mechanisms in the spherical crystallization of bucillamine by the spherical agglomeration and the emulsion solvent diffusion methods

1993 ◽  
Vol 76 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Kenji Morishima ◽  
Yoichi Kawashima ◽  
Yoshiaki Kawashima ◽  
Hirofumi Takeuchi ◽  
Toshiyuki Niwa ◽  
...  
Keyword(s):  
Solvent Diffusion ◽  
Spherical Crystallization

An Overview of Optimization of Spherical Crystallisation Process

2013 ◽  
Vol 6 (4) ◽  
pp. 2203-2209
Author(s):  
N B Bhagat ◽  
A V Yadav ◽  
P R Mastud ◽  
R A Khutale
Keyword(s):  
Physical Phenomenon ◽  
Chemical Properties ◽  
Spherical Shape ◽  
Particle Engineering ◽  
Spherical Crystallization ◽  
Stirring Rate ◽  
Physico Chemical ◽  
Rate Selection ◽  
Pharmaceutical Agents ◽  
Spherical Crystals

In this article we describe the optimizing parameters in the process of spherical crystallisation. Particle engineering of active pharmaceutical agents is an innovative area of research in pharmaceutical industry because of several advantages. Spherical crystallization is one of the particle engineering technique in which drug directly gets crystallized and agglomerated into spherical shape. The spherical crystals can be obtained by different methods like solvent change, Quasi-emulsion droplet, ammonia diffusion and neutralisation. The optimization of process of spherical crystallization is important for obtaining the ideal spherical crystal agglomerates. It includes stirring rate, selection of solvent, pH, temperature etc. which affects on the physico-chemical properties of crystals. These optimizing parameters play its specific role in formation of spherical crystals. Stirring rate affects the shape as well as size of the final agglomerates and solvent selection helps in the formation of maximum amount of agglomerates in the system. The factors like pH and temperature should be maintained in case of drugs which show polymorphism. Apart from this, several others physical phenomenon or parameters like interfacial tension and rate of crystallisation are also important for thorough optimization of process.  

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