Effective Suppression of Antiphase Domains in GaP(N)/GaP Heterostructures on Si(001)

2019 ◽  
Vol 19 (8) ◽  
pp. 4510-4520 ◽  
Author(s):  
Alexey D. Bolshakov ◽  
Vladimir V. Fedorov ◽  
Olga Yu. Koval ◽  
Georgiy A. Sapunov ◽  
Maxim S. Sobolev ◽  
...  
Author(s):  
K.M. Jones ◽  
M.M. Al-Jassim ◽  
J.M. Olson

The epitaxial growth of III-V semiconductors on Si for integrated optoelectronic applications is currently of great interest. GaP, with a lattice constant close to that of Si, is an attractive buffer between Si and, for example, GaAsP. In spite of the good lattice match, the growth of device quality GaP on Si is not without difficulty. The formation of antiphase domains, the difficulty in cleaning the Si substrates prior to growth, and the poor layer morphology are some of the problems encountered. In this work, the structural perfection of GaP layers was investigated as a function of several process variables including growth rate and temperature, and Si substrate orientation. The GaP layers were grown in an atmospheric pressure metal organic chemical vapour deposition (MOCVD) system using trimethylgallium and phosphine in H2. The Si substrates orientations used were (100), 2° off (100) towards (110), (111) and (211).


Author(s):  
Masaru Itakura ◽  
Noriyuki Kuwano ◽  
Kensuke Oki

The low temperature phase of Pd5Ce (L-Pd5Ce) has a one-dimensional long period superstructure (1D-LPS) derived from Ll2. The periodic antiphase boundaries (APBs) are parallel to (110) planes and have a shift vector of 1/2[110]. Hereafter, the indices are referred to the basic lattices of Ll2 As insertion of the APB causes a change in composition, such an APB is called “non-conservative”. Then, a domain size M depends upon the Ce concentration in the alloy. It was found that M increases also with temperature. The temperature dependency of M is attributed to a change of the degree of order within the antiphase domains. In this work, morphology of the non-conservative APBs is observed to clarify the formation process of the 1D-LPS.The alloy of Pd-16.7 at%Ce was prepared by arc melting in argon atmosphere. Disc specimens made from the alloy ingot were first held at 985 K for 260 ks and quenched in iced water to obtain the state of M=∞ or Ll2, followed by annealing for various lengths of time. The annealing temperature was 873 K where the equilibrium value for M is about 3 in unit of (110) lattice spacing of Ll2. Observation was carried out using microscopes JEM-2000FX, JEM-4000EX (HVEM Lab., Kyushu Univ.) and JEM-2000EX (Dept. of Mater. Sci. Tech., Kyushu Univ.).


1984 ◽  
Vol 107 (3) ◽  
pp. 489-494 ◽  
Author(s):  
Wolfgang F. Müller ◽  
Ralf J. John ◽  
Herbert Kroll
Keyword(s):  

2017 ◽  
Author(s):  
Osamu Ichikawa ◽  
Takashi Fukuda ◽  
Gakuto Kurata ◽  
Steven J. Rennie

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ryan Kolb ◽  
Umasankar De ◽  
Sajid Khan ◽  
Yuewan Luo ◽  
Myung-Chul Kim ◽  
...  

AbstractRegulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an immunosuppressive microenvironment. Therapeutic strategies that can eliminate Tregs in the tumor (i.e., therapies that do not run the risk of affecting normal tissues), are urgently needed for the development of cancer immunotherapies. Here we report our discovery of B-cell lymphoma extra-large (BCL-XL) as a potential molecular target of tumor-infiltrating (TI) Tregs. We show that pharmacological degradation of BCL-XL using a newly developed platelet-sparing BCL-XL Proteolysis-targeting chimera (PROTAC) induces the apoptosis of TI-Tregs and the activation of TI-CD8+ T cells. Moreover, these activities result in an effective suppression of syngeneic tumor growth in immunocompetent, but not in immunodeficient or CD8+ T cell-depleted mice. Notably, treatment with BCL-XL PROTAC does not cause detectable damage within several normal tissues or thrombocytopenia. These findings identify BCL-XL as a target in the elimination of TI-Tregs as a component of cancer immunotherapies, and that the BCL-XL-specific PROTAC has the potential to be developed as a therapeutic for cancer immunotherapy.


1976 ◽  
Vol 63 (6) ◽  
pp. 294-294 ◽  
Author(s):  
W. F. M�ller ◽  
H. Schulz
Keyword(s):  

ACS Omega ◽  
2018 ◽  
Vol 3 (12) ◽  
pp. 16465-16471 ◽  
Author(s):  
Jin Hong Lee ◽  
Jisoo Kang ◽  
Seung-Wan Kim ◽  
Willy Halim ◽  
Margaret W. Frey ◽  
...  

2015 ◽  
Vol 240 (9) ◽  
pp. 1136-1146 ◽  
Author(s):  
Doo Suk Lee ◽  
Binna N. Kim ◽  
Seonung Lim ◽  
Junsub Lee ◽  
Jiyoung Kim ◽  
...  

2016 ◽  
Vol 378 ◽  
pp. 467-472 ◽  
Author(s):  
Yuri Kamon ◽  
Naoko Inoue ◽  
Erika Mihara ◽  
Yukiya Kitayama ◽  
Tooru Ooya ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document