Cocrystal Engineering of Itraconazole with Suberic Acid via Rotary Evaporation and Spray Drying

2019 ◽  
Vol 19 (5) ◽  
pp. 2736-2745 ◽  
Author(s):  
Jingwen Weng ◽  
Si Nga Wong ◽  
Xiaoyan Xu ◽  
Bianfei Xuan ◽  
Chenguang Wang ◽  
...  
Keyword(s):  
Spray Drying ◽  
Suberic Acid ◽  
Rotary Evaporation

scholarly journals Improved Dissolution Behavior of Aceclofenac Loadings with Kollidon VA 64 Using Spray Drying and Rotary Evaporation Process

Polymer Korea ◽  
2015 ◽  
Vol 39 (1) ◽  
pp. 6-12
Author(s):  
Jaewon Yang ◽  
Jin Young Park ◽  
Cheon Jung Lee ◽  
Hye Min Kim ◽  
Hyun Gu Lee ◽  
...  
Keyword(s):  
Spray Drying ◽  
Dissolution Behavior ◽  
Evaporation Process ◽  
Rotary Evaporation

scholarly journals FORMULATION OF CURCUMIN NANOSUSPENSION USING BOX-BEHNKEN DESIGN AND STUDY OF IMPACT OF DRYING TECHNIQUES ON ITS POWDER CHARACTERISTICS

2017 ◽  
Vol 10 (16) ◽  
pp. 43 ◽  
Author(s):  
Jasmine Kaur ◽  
Palak Bawa ◽  
Sarvi Yadav Rajesh ◽  
Parth Sharma ◽  
Deepak Ghai ◽  
...  
Keyword(s):  
Particle Size ◽  
Dissolution Rate ◽  
Spray Drying ◽  
Solidification Process ◽  
Stability Study ◽  
Vinyl Pyrrolidone ◽  
Critical Parameters ◽  
Lauryl Sulfate ◽  
Box Behnken Design ◽  
Rotary Evaporation

  Objective: The objective of this study was to formulate curcumin nanosuspension (NS) using Box-Behnken design (BBD) and solvent-antisolvent technique to overcome the challenges related to its poor dissolution rate.Methods: Sodium lauryl sulfate (SLS) and poly vinyl pyrrolidone K-60 (PVPK-60) have been used as a surfactant and polymer, respectively, to stabilize the NS. Ethanol was used as solvent to dissolve curcumin and water was used as antisolvent. The study revealed that SLS to curcumin ratio, PVPK-60 to curcumin ratio, solvent to antisolvent ratio and speed of mixing were the critical parameters that affected particle size and zeta potential of the formulation. Hence, based on Box- BBD, 25 formulations were prepared by varying these critical parameters. The optimized batch of CRM NS was further solidified using spray drying as well as rotary evaporation techniques to have a better insight for selection of solidification process in terms of retention of particle size, charge, flow, dissolution, and stability.Results: About 39.47 folds decrease in particle size of raw CRM was observed after conversion into NS. Further, about 53.57 and 45.45 folds decrease in particle size was observed after spray drying and rotary evaporation. Both the dried nanoparticles have shown comparatively higher solubility, powder flow, and dissolution rate as that of raw CRM. Powder X-ray diffraction study revealed the formation of amorphous nanoparticles. Accelerated stability study revealed that nanoparticles dried by spray drying were able to retain the properties such as particle size, flow, and dissolution rate as compared to rotary evaporated powders.Conclusion: It can be concluded that spray drying technique could offer many advantages while loading CRM nanoparticles into tablets for their oral administration.

Preparation and Characterization of Monodispersed and Spherical YAG Powder for Transparent Ceramic by Spray Drying

2015 ◽  
Vol 30 (5) ◽  
pp. 487 ◽  
Author(s):  
ZHANG Le ◽  
ZHOU Tian-Yuan ◽  
YANG Hao ◽  
QIAO Xue-Bin ◽  
WANG Zhong-Ying ◽  
...  
Keyword(s):  
Spray Drying ◽  
Transparent Ceramic

OSA modified starch in lipid encapsulation by spray drying

2013 ◽  
pp. 45-61
Author(s):  
Ewa Domian ◽  
Ewa Świrydow ◽  
Jan Cenkier
Keyword(s):  
Spray Drying ◽  
Modified Starch

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

TEKNOLOGI PENANGANAN EMISI GAS DARI INSINERATOR SAMPAH KOTA

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Prasetiyadi Prasetiyadi ◽  
Wiharja Wiharja ◽  
Sri Wahyono
Keyword(s):  
Fly Ash ◽  
Pressure Drop ◽  
Spray Drying ◽  
Flue Gas ◽  
Bag Filter

Proses pembakaran sampah kota melalui insinerator akan menghasilkan uap panas yang bisa dimanfaatkan  untuk membangkitkan energi listrik, akan tetapi pada proses ini juga menghasilkan output berupa flue gas yang didominasi oleh partikel (fly ash) dan gas beracun seperti: HCl, SO2, NOx, HF, Hg, Cd dan Dioxin. Sebelum dibuang ke udara bebas, flue gas tersebut harus diolah agar memenuhi baku mutu lingkungan. Teknologi penanganan partikel dan gas polutan tersedia dan dapat dibuat dengan berbagai kapasitas. Untuk menangani flue gas dari insinerator sampah digunakan Quencher untuk menekan laju pembentukan kembali dioksin dan furan setelah proses pembakaran,  Spray Drying Absorption (SDA) untuk mengikat gas asam dan  logam berat serta bag filter untuk menangkap partikel. Selain itu digunakan ID Fan dan Cerobong Asap untuk pengatasi pressure drop yang terjadi akibat pengoperasian peralatan APC dan melepas ke udara.

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