Identification and Characterization of a New Class of (6–4) Photolyase from Vibrio cholerae

Biochemistry ◽  
2019 ◽  
Vol 58 (43) ◽  
pp. 4352-4360 ◽  
Author(s):  
Ugur Meric Dikbas ◽  
Mehmet Tardu ◽  
Asena Canturk ◽  
Seref Gul ◽  
Gozde Ozcelik ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
New Class ◽  
Identification And Characterization

scholarly journals Identification and Characterization of OscR, a Transcriptional Regulator Involved in Osmolarity Adaptation in Vibrio cholerae

2009 ◽  
Vol 191 (13) ◽  
pp. 4082-4096 ◽  
Author(s):  
Nicholas J. Shikuma ◽  
Fitnat H. Yildiz
Keyword(s):  
Vibrio Cholerae ◽  
Biofilm Formation ◽  
Transcriptional Regulator ◽  
Dependent Manner ◽  
Genome Wide ◽  
Low Salt ◽  
Adaptation Response ◽  
Matrix Production ◽  
Identification And Characterization

ABSTRACT Vibrio cholerae is a facultative human pathogen. In its aquatic habitat and as it passes through the digestive tract, V. cholerae must cope with fluctuations in salinity. We analyzed the genome-wide transcriptional profile of V. cholerae grown at different NaCl concentrations and determined that the expression of compatible solute biosynthesis and transporter genes, virulence genes, and genes involved in adhesion and biofilm formation is differentially regulated. We determined that salinity modulates biofilm formation, and this response was mediated through the transcriptional regulators VpsR and VpsT. Additionally, a transcriptional regulator controlling an osmolarity adaptation response was identified. This regulator, OscR (osmolarity controlled regulator), was found to modulate the transcription of genes involved in biofilm matrix production and motility in a salinity-dependent manner. oscR mutants were less motile and exhibited enhanced biofilm formation only under low-salt conditions.

scholarly journals Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy

2017 ◽  
Vol 58 (14) ◽  
pp. 6500 ◽  
Author(s):  
Shu-Jie Zhang ◽  
Xue Chen ◽  
Chao-Peng Li ◽  
Xiu-Miao Li ◽  
Chang Liu ◽  
...  
Keyword(s):  
Circular Rnas ◽  
New Class ◽  
Diabetes Retinopathy ◽  
Identification And Characterization

scholarly journals Identification and Characterization of a New Class of Trafficking Motifs for Controlling Clathrin-independent Internalization and Recycling

2007 ◽  
Vol 282 (17) ◽  
pp. 13087-13097 ◽  
Author(s):  
Qiang Gong ◽  
Michael Weide ◽  
Christopher Huntsman ◽  
Zhuojin Xu ◽  
Lily Y. Jan ◽  
...  
Keyword(s):  
New Class ◽  
Identification And Characterization

scholarly journals A mycobacterial glycine-rich protein governs actin-based motility

2021 ◽  
Author(s):  
Norbert S. Hill ◽  
Matthew D. Welch
Keyword(s):  
Lipid Droplet ◽  
Actin Polymerization ◽  
Close Relative ◽  
Bacterial Surface ◽  
Motility Factor ◽  
New Class ◽  
Intracellular Movement ◽  
Mycobacterial Pathogenesis ◽  
Identification And Characterization

Mycobacterium marinum, a close relative of the significant human pathogen Mycobacterium tuberculosis, polymerizes host actin at the bacterial surface to drive intracellular movement and cell-to-cell spread during infection. Here, we report the identification and characterization of MirA, the M. marinum actin-based motility factor. MirA is a member of the glycine-rich PE_PGRS family of ESX-5-secreted proteins. MirA uses an amphipathic helix to anchor into the mycobacterial outer membrane and, surprisingly, also the surface of host lipid droplet organelles. The glycine-rich PGRS domain in MirA directly binds and activates host N-WASP to stimulate actin polymerization through the Arp2/3 complex, directing both bacterial and lipid droplet actin-based motility. MirA is dissimilar to known N-WASP activating ligands and may represent a new class of microbial and host actin regulator. Additionally, the MirA-N-WASP interaction represents a model to understand how the enigmatic PE_PGRS proteins contribute to mycobacterial pathogenesis.

scholarly journals Long read sequencing reveals a novel class of structural aberrations in cancers: identification and characterization of cancerous local amplifications

2019 ◽  
Author(s):  
Yoshitaka Sakamoto ◽  
Liu Xu ◽  
Masahide Seki ◽  
Toshiyuki T. Yokoyama ◽  
Masahiro Kasahara ◽  
...  
Keyword(s):  
Point Mutations ◽  
Lung Cancers ◽  
New Class ◽  
Large Deletions ◽  
Long Read ◽  
Structural Aberrations ◽  
Molecular Etiology ◽  
Identification And Characterization

AbstractHere we report identification of a new class of local structural aberrations in lung cancers. The whole-genome sequencing of cell lines using a long read sequencer, PromethION, demonstrated that typical cancerous mutations, such as point mutations, large deletions and gene fusions can be detected also on this platform. Unexpectedly, we revealed unique structural aberrations consisting of complex combinations of local duplications, inversions and micro deletions. We further analyzed and found that these mutations also occur in vivo, even in key cancer-related genes. These mutations may elucidate the molecular etiology of patients for whom causative cancerous events and therapeutic strategies remain elusive.

scholarly journals Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141214 ◽  
Author(s):  
Sebastian Memczak ◽  
Panagiotis Papavasileiou ◽  
Oliver Peters ◽  
Nikolaus Rajewsky
Keyword(s):  
Human Blood ◽  
Circular Rnas ◽  
New Class ◽  
Identification And Characterization

scholarly journals Identification and Characterization of a New Class of Bilin Lyase

2006 ◽  
Vol 281 (26) ◽  
pp. 17768-17778 ◽  
Author(s):  
Gaozhong Shen ◽  
Nicolle A. Saunée ◽  
Shervonda R. Williams ◽  
Eduardo F. Gallo ◽  
Wendy M. Schluchter ◽  
...  
Keyword(s):  
New Class ◽  
Identification And Characterization
Sign in / Sign up

Export Citation Format

Share Document