Dissecting the Antenna in Human Glutamate Dehydrogenase: Understanding Its Role in Subunit Communication and Allosteric Regulation

Biochemistry ◽  
2019 ◽  
Vol 58 (41) ◽  
pp. 4195-4206
Author(s):  
Zoe A. Hoffpauir ◽  
Eleena Sherman ◽  
Thomas J. Smith
Keyword(s):  
Glutamate Dehydrogenase ◽  
Allosteric Regulation ◽  
Subunit Communication

scholarly journals The structure and allosteric regulation of mammalian glutamate dehydrogenase

2012 ◽  
Vol 519 (2) ◽  
pp. 69-80 ◽  
Author(s):  
Ming Li ◽  
Changhong Li ◽  
Aron Allen ◽  
Charles A. Stanley ◽  
Thomas J. Smith
Keyword(s):  
Glutamate Dehydrogenase ◽  
Allosteric Regulation

scholarly journals Allosteric regulation: Illuminating allosteric conformational change with an environmentally sensitive fluorescent probe

2015 ◽  
Vol 37 (3) ◽  
pp. 54-57
Author(s):  
Robert B. Freedman ◽  
Alan D.B. Malcolm
Keyword(s):  
Glutamate Dehydrogenase ◽  
Fluorescent Probe ◽  
Conformational Change ◽  
Conformational Changes ◽  
Allosteric Regulation ◽  
Structural Data ◽  
Biochemical Journal ◽  
Environmentally Sensitive ◽  
The 1960S ◽  
Classic Paper

Allosteric regulation was a hot topic in the 1960s, but there was very limited structural data on allosteric equilibria, and no solid information on the rates of allosteric conformational changes. In this Biochemical Journal Classic paper from 1969 George Radda and his first D.Phil. student, George Dodd determined the rate of allosteric transition in the regulatory enzyme glutamate dehydrogenase by a method new in the 1960s, the fluorescence of an environmentally sensitive extrinsic probe.

scholarly journals Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Karolina Luczkowska ◽  
Caroline Stekelenburg ◽  
Frédérique Sloan-Béna ◽  
Emmanuelle Ranza ◽  
Giacomo Gastaldi ◽  
...  
Keyword(s):  
Glutamate Dehydrogenase ◽  
Functional Characterization ◽  
Allosteric Regulation

scholarly journals The structure and allosteric regulation of glutamate dehydrogenase

2011 ◽  
Vol 59 (4) ◽  
pp. 445-455 ◽  
Author(s):  
Ming Li ◽  
Changhong Li ◽  
Aron Allen ◽  
Charles A. Stanley ◽  
Thomas J. Smith
Keyword(s):  
Glutamate Dehydrogenase ◽  
Allosteric Regulation
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