Identification and Rationalization of Kinetic Folding Intermediates for a Low-Density Lipoprotein Receptor Ligand-Binding Module

Biochemistry ◽  
2018 ◽  
Vol 57 (32) ◽  
pp. 4776-4787 ◽  
Author(s):  
Or Szekely ◽  
Gad Armony ◽  
Gregory Lars Olsen ◽  
Lavi S. Bigman ◽  
Yaakov Levy ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Receptor Ligand ◽  
Folding Intermediates ◽  
Density Lipoprotein Receptor ◽  
Kinetic Folding

Structural features of the low-density lipoprotein receptor facilitating ligand binding and release

2004 ◽  
Vol 32 (5) ◽  
pp. 721-723 ◽  
Author(s):  
N. Beglova ◽  
H. Jeon ◽  
C. Fisher ◽  
S.C. Blacklow
Keyword(s):  
Ligand Binding ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Structural Features ◽  
Low Ph ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
Epidermal Growth

The LDLR (low-density lipoprotein receptor) is a modular protein built from several distinct structural units: LA (LDLR type-A), epidermal growth factor-like and β-propeller modules. The low pH X-ray structure of the LDLR revealed long-range intramolecular contacts between the propeller domain and the central LA repeats of the ligand-binding domain, suggesting that the receptor changes its overall shape from extended to closed, in response to pH. Here we discuss how the LDLR uses flexibility and rigidity of linkers between modules to facilitate ligand binding and low-pH ligand release.

scholarly journals Ligand Binding Properties of the Very Low Density Lipoprotein Receptor

1999 ◽  
Vol 274 (13) ◽  
pp. 8973-8980 ◽  
Author(s):  
Peter M. Rettenberger ◽  
Kazuhiro Oka ◽  
Lars Ellgaard ◽  
Helle H. Petersen ◽  
Anni Christensen ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Binding Properties ◽  
Density Lipoprotein Receptor
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