scholarly journals Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9

Biochemistry ◽  
2017 ◽  
Vol 56 (41) ◽  
pp. 5476-5480 ◽  
Author(s):  
Keiko Maekawa ◽  
Motoyasu Adachi ◽  
Yumiko Matsuzawa ◽  
Qinghai Zhang ◽  
Ryota Kuroki ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Single Nucleotide Polymorphisms ◽  
Structural Basis ◽  
Nucleotide Polymorphisms ◽  
Cytochrome P450 2C9 ◽  
Single Nucleotide

scholarly journals Polymorphisms in the cytochrome P450 CYP1A1, CYP1A2, CYP1B1 genes and risk of colorectal cancer in a population from Central Russia

2020 ◽  
pp. 60-61
Author(s):  
А.С. Москалев ◽  
Ф.В. Подольский ◽  
С.М. Зайцев ◽  
Е.А. Новикова ◽  
А.В. Полоников ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cytochrome P450 ◽  
Single Nucleotide Polymorphisms ◽  
Healthy Controls ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Central Russia ◽  
Increased Risk ◽  
Age And Sex

В исследование были включены 256 пациентов с колоректальным раком (134 мужчины, 122 женщины) и 608 практически здоровых добровольцев (279 мужчин, 329 женщин). Генотипирование однонуклеотидных полиморфизмов I462V (rs1048943) CYP1A1, -154A>C (rs762551) CYP1A2 и L432V (rs1056836) CYP1B1 было проведено методом ПЦР в режиме реального времени. Полиморфизм rs1056836 CYP1B1 (замена L432V) ассоциировался с повышенным риском колоректального рака в популяции Центральной России: OR=1,48, 95%CI=1,07-2,04; р=0,02. A total of 256 patients with colorectal cancer (134 males, 122 females) and 608 age- and sex-matched healthy controls (279 males, 329 females) were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) I462V (rs1048943) CYP1A1, -154A>C (rs762551) CYP1A2 and L432V (rs1056836) CYP1B1 were done using Taq-Man-based assays. Polymorphism rs1056836 (substitution L432V) CYP1B1 was associated with increased risk of colorectal cancer in the population from Central Russia: OR=1,48, 95%CI=1,07-2,04; p=0,02.

scholarly journals The Impact of Genetic Variability of CYP1A2, ADORA2A, and AHR on Caffeine Consumption and Response among Adult New Zealanders

Proceedings ◽  
2019 ◽  
Vol 37 (1) ◽  
pp. 30
Author(s):  
Tennent ◽  
Rutherfurd-Markwick ◽  
Ali ◽  
Wham
Keyword(s):  
Cytochrome P450 ◽  
Genetic Variability ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Caffeine Consumption ◽  
Cytochrome P450 1A2 ◽  
Single Nucleotide ◽  
The Impact ◽  
New Zealanders

Three single nucleotide polymorphisms (SNPs) have known links to caffeine consumption,metabolism, and post-consumption effects and responses: cytochrome P450 1A2 (CYP1A2; rs762551) [...]

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