scholarly journals Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases

Biochemistry ◽  
2016 ◽  
Vol 55 (46) ◽  
pp. 6359-6362 ◽  
Author(s):  
Sydney P. Thomas ◽  
Eunji Kim ◽  
Jin-Soo Kim ◽  
Ronald T. Raines
Keyword(s):  
Human Cells ◽  
Ribonuclease Inhibitor ◽  
Inhibitor Gene

A chimaeric ribonuclease-inhibitor gene restores fertility to male sterile plants

Nature ◽  
1992 ◽  
Vol 357 (6377) ◽  
pp. 384-387 ◽  
Author(s):  
Celestina Mariani ◽  
Veronique Gossele ◽  
Marc De Beuckeleer ◽  
Marc De Block ◽  
Robert B. Goldberg ◽  
...  
Keyword(s):  
Male Sterile ◽  
Ribonuclease Inhibitor ◽  
Inhibitor Gene

Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization

Genomics ◽  
1990 ◽  
Vol 8 (1) ◽  
pp. 175-178 ◽  
Author(s):  
Susan M. Zneimer ◽  
David Crawford ◽  
Nancy R. Schneider ◽  
Bruce Beutler
Keyword(s):  
In Situ Hybridization ◽  
Ribonuclease Inhibitor ◽  
Chromosome 11P15 ◽  
Inhibitor Gene

Antitumor effects of human ribonuclease inhibitor gene transfected on B16 melanoma cells

2005 ◽  
Vol 37 (6) ◽  
pp. 1219-1231 ◽  
Author(s):  
Jun-Xia Chen ◽  
Ying Gao ◽  
Ji-Wei Liu ◽  
Yu-Xiang Tian ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Ribonuclease Inhibitor ◽  
Antitumor Effects ◽  
B16 Melanoma Cells ◽  
Inhibitor Gene

Alpha-Tocopherol Protects Cultured Human Cells from the Acute Lethal Cytotoxicity of Dioxin

2002 ◽  
Vol 72 (3) ◽  
pp. 147-153 ◽  
Author(s):  
Kei-Ichi Hirai ◽  
Jie-Hong Pan ◽  
Ying-Bo Shui ◽  
Eriko Simamura ◽  
Hiroki Shimada ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Smooth Endoplasmic Reticulum ◽  
Dehydroascorbic Acid ◽  
Human Cells ◽  
Alpha Tocopherol ◽  
Cervical Cancer Cells ◽  
Cultured Human Cells ◽  
Nuclear Damage ◽  
Conjunctival Epithelial Cells

The possible protection of cultured human cells from acute dioxin injury by antioxidants was investigated. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), caused vacuolization of the smooth endoplasmic reticulum and Golgi apparatus in cultured human conjunctival epithelial cells and cervical cancer cells. Subsequent nuclear damage included a deep irregular indentation resulting in cell death. A dosage of 30–40 ng/mL TCDD induced maximal intracellular production of H2O2 at 30 minutes and led to severe cell death (0–31% survival) at two hours. A dose of 1.7 mM alpha-tocopherol or 1 mM L-dehydroascorbic acid significantly protected human cells against acute TCDD injuries (78–97% survivals), but vitamin C did not provide this protection. These results indicate that accidental exposure to fatal doses of TCDD causes cytoplasmic free radical production within the smooth endoplasmic reticular systems, resulting in severe cytotoxicity, and that vitamin E and dehydroascorbic acid can protect against TCDD-induced cell damage.

Chromium oxidation state mapping in human cells

2003 ◽  
Vol 104 ◽  
pp. 289-292 ◽  
Author(s):  
R. Ortega ◽  
B. Fayard ◽  
M. Salomé ◽  
G. Devès ◽  
J. Susini
Keyword(s):  
Oxidation State ◽  
Human Cells ◽  
Chromium Oxidation

The role of the N34S mutation in the trypsin inhibitor gene SPINK1 in patients with chronic pancreatitis from Romania

2009 ◽  
Vol 47 (06) ◽  
Author(s):  
B Diaconu ◽  
A Schneider ◽  
R Pfützer ◽  
T Mocan ◽  
M Scăfaru ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Trypsin Inhibitor ◽  
N34s Mutation ◽  
Inhibitor Gene

The Role of Serine Peptidase Inhibitor Gene Variants in Asthma Development

2019 ◽  
Author(s):  
Hanna Angstmann ◽  
Karin Uliczka ◽  
Thomas Roeder ◽  
Susanne Krauss-Etschmann ◽  
Christina Wagner
Keyword(s):  
Gene Variants ◽  
Serine Peptidase ◽  
Peptidase Inhibitor ◽  
Inhibitor Gene

Transport of clozapine and its major metabolites into human cells of glial and neuronal origin

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
U Henning ◽  
K Krieger ◽  
S Loeffler ◽  
A Klimke
Keyword(s):  
Human Cells

Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland

2015 ◽  
Author(s):  
Gerard Ruiz Babot ◽  
Irene Hadjidemetriou ◽  
Sharon Jane Ajodha ◽  
David Taylor ◽  
Norman Taylor ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
New Technology ◽  
Human Cells
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