scholarly journals SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin

Biochemistry ◽  
2015 ◽  
Vol 54 (45) ◽  
pp. 6756-6759 ◽  
Author(s):  
Jason Z. Niehaus ◽  
Mark T. Miedel ◽  
Misty Good ◽  
Allyson N. Wyatt ◽  
Stephen C. Pak ◽  
...  
Keyword(s):  
Granzyme A ◽  
Slow Binding Inhibitor

scholarly journals Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides.

1992 ◽  
Vol 267 (35) ◽  
pp. 25488-25493
Author(s):  
R.J. Hershberger ◽  
H.K. Gershenfeld ◽  
I.L. Weissman ◽  
L Su
Keyword(s):  
Genomic Organization ◽  
Granzyme A ◽  
Leader Peptides

Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol

2012 ◽  
Vol 28 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Sara R. Schlesinger ◽  
Britain Bruner ◽  
Patrick J. Farmer ◽  
Sung-Kun Kim
Keyword(s):  
Kinetic Characterization ◽  
Slow Binding Inhibitor

scholarly journals Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor

Cell ◽  
2003 ◽  
Vol 112 (5) ◽  
pp. 659-672 ◽  
Author(s):  
Zusen Fan ◽  
Paul J. Beresford ◽  
David Y. Oh ◽  
Dong Zhang ◽  
Judy Lieberman
Keyword(s):  
Tumor Suppressor ◽  
Nucleosome Assembly ◽  
Nucleosome Assembly Protein ◽  
Granzyme A

scholarly journals d-alanine: d-alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme

1992 ◽  
Vol 282 (3) ◽  
pp. 747-752 ◽  
Author(s):  
O A M al-Bar ◽  
C D O'Connor ◽  
I G Giles ◽  
M Akhtar
Keyword(s):  
Escherichia Coli ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Gene Sequence ◽  
Phosphinic Acid ◽  
Mature Protein ◽  
Bamhi Fragment ◽  
E Coli ◽  
Escherichia Coli Expression ◽  
Slow Binding Inhibitor

A 1.2 kb BamHI fragment from pDK30 [Robinson, Kenan, Sweeney & Donachie (1986) J. Bacteriol. 167, 809-817] was cloned in pDOC55 [O'Connor & Timmis (1987) J. Bacteriol. 169, 4457-4482] to give two constructs, pDOC89 and pDOC87, in which the Escherichia coli D-alanine:D-alanine ligase (EC 6.3.2.4) gene (ddl) was placed under the control of the lac and lambda PL promoters respectively. Both constructs, when used to transform E. coli M72, gave similar levels of expression of the ddl gene. The expressed enzyme was purified to homogeneity and the amino acid sequence of its N-terminal region was found to be consistent with that predicted from the gene sequence, except that the N-terminal methionine was not present in the mature protein. [1(S)-Aminoethyl][(2RS)2-carboxy-1-octyl]phosphinic acid (I), previously shown to bind tightly to Enterococcus faecalis and Salmonella typhimurium D-alanine:D-alanine ligases following phosphorylation Parsons, Patchett, Bull, Schoen, Taub, Davidson, Combs, Springer, Gadebusch, Weissberger, Valiant, Mellin & Busch (1988) J. Med. Chem. 31, 1772-1778; Duncan & Walsh (1988) Biochemistry 27, 3709-3714], was found to be a classical slow-binding inhibitor of the E. coli ligase.

Inhibition of lymphocyte protease granzyme A by antithrombin III

1988 ◽  
Vol 25 (12) ◽  
pp. 1283-1289 ◽  
Author(s):  
Daniéle Masson ◽  
Jürg Tschopp
Keyword(s):  
Antithrombin Iii ◽  
Granzyme A

scholarly journals Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway

Cell Reports ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. 910-917 ◽  
Author(s):  
Dagmar Hildebrand ◽  
Konrad A. Bode ◽  
David Rieß ◽  
Daniela Cerny ◽  
Anna Waldhuber ◽  
...  
Keyword(s):  
Granzyme A
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