scholarly journals Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway

Cell Reports ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. 910-917 ◽  
Author(s):  
Dagmar Hildebrand ◽  
Konrad A. Bode ◽  
David Rieß ◽  
Daniela Cerny ◽  
Anna Waldhuber ◽  
...  
Keyword(s):  
Granzyme A

scholarly journals Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides.

1992 ◽  
Vol 267 (35) ◽  
pp. 25488-25493
Author(s):  
R.J. Hershberger ◽  
H.K. Gershenfeld ◽  
I.L. Weissman ◽  
L Su
Keyword(s):  
Genomic Organization ◽  
Granzyme A ◽  
Leader Peptides

scholarly journals Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor

Cell ◽  
2003 ◽  
Vol 112 (5) ◽  
pp. 659-672 ◽  
Author(s):  
Zusen Fan ◽  
Paul J. Beresford ◽  
David Y. Oh ◽  
Dong Zhang ◽  
Judy Lieberman
Keyword(s):  
Tumor Suppressor ◽  
Nucleosome Assembly ◽  
Nucleosome Assembly Protein ◽  
Granzyme A

Inhibition of lymphocyte protease granzyme A by antithrombin III

1988 ◽  
Vol 25 (12) ◽  
pp. 1283-1289 ◽  
Author(s):  
Daniéle Masson ◽  
Jürg Tschopp
Keyword(s):  
Antithrombin Iii ◽  
Granzyme A

Roles of granzyme A in pathology of patients with atopic dermatitis

2016 ◽  
Vol 84 (1) ◽  
pp. e17
Author(s):  
Yayoi Kamata ◽  
Utako Kimura ◽  
Hironori Matsuda ◽  
Suhandy Tengara ◽  
Kyoichi Iizumi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Granzyme A

scholarly journals Granzyme A Causes Detachment of Alveolar Epithelial A549 Cells Accompanied by Promotion of Interleukin-8 Release

2008 ◽  
Vol 72 (9) ◽  
pp. 2481-2484 ◽  
Author(s):  
Yumiko YOSHIKAWA ◽  
Hirofumi HIRAYASU ◽  
Satoshi TSUZUKI ◽  
Tohru FUSHIKI
Keyword(s):  
A549 Cells ◽  
Interleukin 8 ◽  
Alveolar Epithelial ◽  
Granzyme A

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Science ◽  
2020 ◽  
Vol 368 (6494) ◽  
pp. eaaz7548 ◽  
Author(s):  
Zhiwei Zhou ◽  
Huabin He ◽  
Kun Wang ◽  
Xuyan Shi ◽  
Yupeng Wang ◽  
...  
Keyword(s):  
Antitumor Immunity ◽  
Interferon Γ ◽  
Target Cells ◽  
Cytotoxic Lymphocytes ◽  
Cytotoxic Lymphocyte ◽  
Granzyme A ◽  
Tumor Clearance ◽  
Ifn Γ ◽  
Underlying Mechanisms ◽  
Pore Forming Proteins

Cytotoxic lymphocyte–mediated immunity relies on granzymes. Granzymes are thought to kill target cells by inducing apoptosis, although the underlying mechanisms are not fully understood. Here, we report that natural killer cells and cytotoxic T lymphocytes kill gasdermin B (GSDMB)–positive cells through pyroptosis, a form of proinflammatory cell death executed by the gasdermin family of pore-forming proteins. Killing results from the cleavage of GSDMB by lymphocyte-derived granzyme A (GZMA), which unleashes its pore-forming activity. Interferon-γ (IFN-γ) up-regulates GSDMB expression and promotes pyroptosis. GSDMB is highly expressed in certain tissues, particularly digestive tract epithelia, including derived tumors. Introducing GZMA-cleavable GSDMB into mouse cancer cells promotes tumor clearance in mice. This study establishes gasdermin-mediated pyroptosis as a cytotoxic lymphocyte–killing mechanism, which may enhance antitumor immunity.

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