Hydrophilic Interaction Chromatography Hyphenated with Mass Spectrometry: A Powerful Analytical Tool for the Comparison of Originator and Biosimilar Therapeutic Monoclonal Antibodies at the Middle-up Level of Analysis

Valentina D’Atri; Szabolcs Fekete; Alain Beck; Matthew Lauber; Davy Guillarme

doi:10.1021/acs.analchem.6b04726

Hydrophilic Interaction Chromatography Hyphenated with Mass Spectrometry: A Powerful Analytical Tool for the Comparison of Originator and Biosimilar Therapeutic Monoclonal Antibodies at the Middle-up Level of Analysis

Analytical Chemistry ◽

10.1021/acs.analchem.6b04726 ◽

2017 ◽

Vol 89 (3) ◽

pp. 2086-2092 ◽

Cited By ~ 49

Author(s):

Valentina D’Atri ◽

Szabolcs Fekete ◽

Alain Beck ◽

Matthew Lauber ◽

Davy Guillarme

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Analytical Tool ◽

Hydrophilic Interaction Chromatography ◽

Hydrophilic Interaction ◽

Powerful Analytical Tool ◽

Therapeutic Monoclonal Antibodies ◽

Level Of Analysis

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Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2018.03.034 ◽

2018 ◽

Vol 154 ◽

pp. 468-475 ◽

Cited By ~ 16

Author(s):

Shunhai Wang ◽

Anita P. Liu ◽

Yuetian Yan ◽

Thomas J. Daly ◽

Ning Li

Keyword(s):

Mass Spectrometry ◽

Molecular Weight ◽

Monoclonal Antibodies ◽

Hydrophilic Interaction Chromatography ◽

Low Molecular Weight ◽

Hydrophilic Interaction ◽

Therapeutic Monoclonal Antibodies

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Glycan profiling of monoclonal antibodies using zwitterionic-type hydrophilic interaction chromatography coupled with electrospray ionization mass spectrometry detection

Analytical Biochemistry ◽

10.1016/j.ab.2010.09.035 ◽

2011 ◽

Vol 408 (2) ◽

pp. 235-241 ◽

Cited By ~ 36

Author(s):

Lea Mauko ◽

Anna Nordborg ◽

Joseph P. Hutchinson ◽

Nathan A. Lacher ◽

Emily F. Hilder ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Electrospray Ionization ◽

Electrospray Ionization Mass Spectrometry ◽

Hydrophilic Interaction Chromatography ◽

Ionization Mass Spectrometry ◽

Ionization Mass ◽

Mass Spectrometry Detection ◽

Hydrophilic Interaction ◽

Glycan Profiling

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Hydrogen Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

Hydrogen Exchange Mass Spectrometry of Proteins ◽

10.1002/9781118703748.ch18 ◽

2016 ◽

pp. 323-342

Author(s):

Ranajoy Majumdar ◽

C. Russell Middaugh ◽

David D. Weis ◽

David B. Volkin

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Hydrogen Exchange ◽

Analytical Tool ◽

Formulation Development ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry ◽

Therapeutic Monoclonal Antibodies

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Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24224 ◽

2015 ◽

Vol 104 (2) ◽

pp. 327-345 ◽

Cited By ~ 44

Author(s):

Ranajoy Majumdar ◽

C.Russell Middaugh ◽

David D. Weis ◽

David B. Volkin

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Analytical Tool ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Formulation Development ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Therapeutic Monoclonal Antibodies

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Analysis of picric acid and picramic acid in water samples by ultra performance hydrophilic interaction chromatography-tandem mass spectrometry

Chinese Journal of Chromatography ◽

10.3724/sp.j.1123.2013.11037 ◽

2014 ◽

Vol 32 (5) ◽

pp. 535 ◽

Cited By ~ 1

Author(s):

Feizhong QIAN ◽

Libo ZHU ◽

Nengbin XU ◽

Jiayong FENG ◽

Zhengfang HONG ◽

...

Keyword(s):

Mass Spectrometry ◽

Tandem Mass Spectrometry ◽

Water Samples ◽

Picric Acid ◽

Hydrophilic Interaction Chromatography ◽

Tandem Mass ◽

Hydrophilic Interaction ◽

Chromatography Tandem Mass Spectrometry

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Heparin stability by determining unsubstituted amino groups using hydrophilic interaction chromatography mass spectrometry

Analytical Biochemistry ◽

10.1016/j.ab.2014.05.028 ◽

2014 ◽

Vol 461 ◽

pp. 46-48 ◽

Cited By ~ 13

Author(s):

Li Fu ◽

Lingyun Li ◽

Chao Cai ◽

Guoyun Li ◽

Fuming Zhang ◽

...

Keyword(s):

Mass Spectrometry ◽

Hydrophilic Interaction Chromatography ◽

Amino Groups ◽

Hydrophilic Interaction ◽

Chromatography Mass Spectrometry

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A generic sample preparation method for the multiplex analysis of seven therapeutic monoclonal antibodies in human plasma or serum with liquid chromatography-tandem mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2021.462489 ◽

2021 ◽

Vol 1655 ◽

pp. 462489

Author(s):

Mohsin El Amrani ◽

Laszlo Gerencser ◽

Alwin D.R. Huitema ◽

C. Erik Hack ◽

Matthijs van Luin ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Liquid Chromatography ◽

Sample Preparation ◽

Preparation Method ◽

Tandem Mass ◽

Sample Preparation Method ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Therapeutic Monoclonal Antibodies

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Analysis of Underivatized Amino Acids: Zwitterionic Hydrophilic Interaction Chromatography Combined with Triple Quadrupole Tandem Mass Spectrometry

Methods in Molecular Biology - Amino Acid Analysis ◽

10.1007/978-1-4939-9639-1_29 ◽

2019 ◽

pp. 395-402

Author(s):

Madeleine Werneth ◽

Gunda Koellensperger ◽

Stephan Hann

Keyword(s):

Mass Spectrometry ◽

Amino Acids ◽

Tandem Mass Spectrometry ◽

Hydrophilic Interaction Chromatography ◽

Tandem Mass ◽

Triple Quadrupole ◽

Hydrophilic Interaction ◽

Underivatized Amino Acids

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Orthogonal Middle-up Approaches for Characterization of the Glycan Heterogeneity of Etanercept by Hydrophilic Interaction Chromatography Coupled to High-Resolution Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.8b03584 ◽

2018 ◽

Vol 91 (1) ◽

pp. 873-880 ◽

Cited By ~ 14

Author(s):

Valentina D’Atri ◽

Lucie Nováková ◽

Szabolcs Fekete ◽

Dwight Stoll ◽

Matthew Lauber ◽

...

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

High Resolution Mass Spectrometry ◽

Hydrophilic Interaction Chromatography ◽

Hydrophilic Interaction ◽

High Resolution Mass ◽

Glycan Heterogeneity ◽

Resolution Mass

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Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography–electrospray ionization mass spectrometry

Journal of Chromatography B ◽

10.1016/j.jchromb.2013.02.013 ◽

2013 ◽

Vol 923-924 ◽

pp. 83-91 ◽

Cited By ~ 19

Author(s):

Anja Ekdahl ◽

Maria C. Johansson ◽

Martin Ahnoff

Keyword(s):

Mass Spectrometry ◽

Electrospray Ionization ◽

Electrospray Ionization Mass Spectrometry ◽

Matrix Effects ◽

Hydrophilic Interaction Chromatography ◽

Ionization Mass Spectrometry ◽

Ionization Mass ◽

Hydrophilic Interaction

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