Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

Ranajoy Majumdar; C.Russell Middaugh; David D. Weis; David B. Volkin

doi:10.1002/jps.24224

Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24224 ◽

2015 ◽

Vol 104 (2) ◽

pp. 327-345 ◽

Cited By ~ 44

Author(s):

Ranajoy Majumdar ◽

C.Russell Middaugh ◽

David D. Weis ◽

David B. Volkin

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Analytical Tool ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Formulation Development ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Therapeutic Monoclonal Antibodies

Download Full-text

Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

Analytical Chemistry ◽

10.1021/ac404130a ◽

2014 ◽

Vol 86 (7) ◽

pp. 3468-3475 ◽

Cited By ~ 73

Author(s):

Aming Zhang ◽

Ping Hu ◽

Paul MacGregor ◽

Yu Xue ◽

Haihong Fan ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Sequence Variation ◽

Structural Modeling ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Chemical Modifications ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Conformational Analysis of Recombinant Monoclonal Antibodies with Hydrogen/Deuterium Exchange Mass Spectrometry

Methods in Molecular Biology - Glycosylation Engineering of Biopharmaceuticals ◽

10.1007/978-1-62703-327-5_17 ◽

2013 ◽

pp. 269-289 ◽

Cited By ~ 29

Author(s):

Damian Houde ◽

John R. Engen

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Conformational Analysis ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX‐MS): An Accelerated Workflow for Evaluation of Lead Monoclonal Antibodies

Biotechnology Journal ◽

10.1002/biot.202100358 ◽

2021 ◽

pp. 2100358

Author(s):

Shaolong Zhu ◽

Peter Liuni ◽

Tricia Chen ◽

Camille Houy ◽

Derek J. Wilson ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Hdx Ms

Download Full-text

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-017-1831-8 ◽

2017 ◽

Vol 29 (1) ◽

pp. 85-94 ◽

Cited By ~ 4

Author(s):

Thamina Acter ◽

Seulgidaun Lee ◽

Eunji Cho ◽

Maeng-Joon Jung ◽

Sunghwan Kim

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Atmospheric Pressure Photoionization ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Continuous Feeding

Download Full-text

Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry

Journal of Structural Biology ◽

10.1016/j.jsb.2015.04.006 ◽

2015 ◽

Vol 190 (2) ◽

pp. 250-259 ◽

Cited By ~ 11

Author(s):

Dong Kyun Kim ◽

Youngjoo Yun ◽

Hee Ryung Kim ◽

Min-Duk Seo ◽

Ka Young Chung

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

Analytica Chimica Acta ◽

10.1016/j.aca.2016.08.006 ◽

2016 ◽

Vol 940 ◽

pp. 8-20 ◽

Cited By ~ 36

Author(s):

Bin Deng ◽

Cristina Lento ◽

Derek J. Wilson

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Hydrogen-Deuterium Exchange Mass Spectrometry of Phosphorylation Induced Changes in Smooth Muscle Myosin

Biophysical Journal ◽

10.1016/j.bpj.2012.11.2501 ◽

2013 ◽

Vol 104 (2) ◽

pp. 452a

Author(s):

K. Ilker Sen ◽

Brian D. Haldeman ◽

Richard Brizendine ◽

Roger Mercer ◽

Christine R. Cremo ◽

...

Keyword(s):

Mass Spectrometry ◽

Smooth Muscle ◽

Smooth Muscle Myosin ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Induced Changes ◽

Muscle Myosin

Download Full-text

Deglycosylation induces extensive dynamics changes in α-amylase revealed by hydrogen/deuterium exchange mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.6732 ◽

2013 ◽

Vol 27 (23) ◽

pp. 2625-2630 ◽

Cited By ~ 4

Author(s):

Chengjie Ji ◽

Gary Wei

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text

Research advances in hydrogen–deuterium exchange mass spectrometry for protein epitope mapping

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-020-03091-9 ◽

2021 ◽

Author(s):

Haofeng Sun ◽

Lingyun Ma ◽

Leyu Wang ◽

Peng Xiao ◽

Hongmei Li ◽

...

Keyword(s):

Mass Spectrometry ◽

Epitope Mapping ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

Download Full-text