scholarly journals Blu-ray Technology-Based Quantitative Assays for Cardiac Markers: From Disc Activation to Multiplex Detection

2016 ◽  
Vol 88 (13) ◽  
pp. 6889-6896 ◽  
Author(s):  
Samuel Weng ◽  
Xiaochun Li ◽  
Michelle Niu ◽  
Bixia Ge ◽  
Hua-Zhong Yu
Keyword(s):  
Cardiac Markers ◽  
Multiplex Detection

scholarly journals Paper-based cascade cationic isotachophoresis: Multiplex detection of cardiac markers

Talanta ◽  
2019 ◽  
Vol 205 ◽  
pp. 120112 ◽  
Author(s):  
Shuang Guo ◽  
William Schlecht ◽  
Lei Li ◽  
Wen-Ji Dong
Keyword(s):  
Cardiac Markers ◽  
Multiplex Detection

Multiplex detection of cardiac biomarkers

2017 ◽  
Vol 9 (25) ◽  
pp. 3773-3776 ◽  
Author(s):  
Mukesh Digambar Sonawane ◽  
Satish Balasaheb Nimse ◽  
Keum-Soo Song ◽  
Taisun Kim
Keyword(s):  
Cardiac Biomarkers ◽  
Cardiac Markers ◽  
Multiplex Detection

A method for multiplex detection of three cardiac markers cTnI, NT-proBNP, and cTnT specific to CVD is reported.

Autonomous Kit for Multiplex Detection of Antibodies to Infectious Diseases Causes

2018 ◽  
Vol 34 (5) ◽  
pp. 57-66
Author(s):  
A.G. Poltavchenko ◽  
◽  
O.V. Nechitailo ◽  
P.V. Filatov ◽  
A.V. Yorsh
Keyword(s):  
Infectious Diseases ◽  
Multiplex Detection

scholarly journals Implications of cardiac markers in risk-stratification and management for COVID-19 patients

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Pengping Li ◽  
Wei Wu ◽  
Tingting Zhang ◽  
Ziyu Wang ◽  
Jie Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Rna Sequencing ◽  
High Mortality ◽  
Admission Rate ◽  
Serum Levels ◽  
Receptor Expression ◽  
Cardiac Markers ◽  
Artery Disease

Abstract Background COVID-19 has resulted in high mortality worldwide. Information regarding cardiac markers for precise risk-stratification is limited. We aim to discover sensitive and reliable early-warning biomarkers for optimizing management and improving the prognosis of COVID-19 patients. Methods A total of 2954 consecutive COVID-19 patients who were receiving treatment from the Wuhan Huoshenshan Hospital in China from February 4 to April 10 were included in this retrospective cohort. Serum levels of cardiac markers were collected after admission. Coronary artery disease diagnosis and survival status were recorded. Single-cell RNA-sequencing and bulk RNA-sequencing from different cohorts of non-COVID-19 were performed to analyze SARS-CoV-2 receptor expression. Results Among 2954 COVID-19 patients in the analysis, the median age was 60 years (50–68 years), 1461 (49.5%) were female, and 1515 (51.3%) were severe/critical. Compared to mild/moderate (1439, 48.7%) patients, severe/critical patients showed significantly higher levels of cardiac markers within the first week after admission. In severe/critical COVID-19 patients, those with abnormal serum levels of BNP (42 [24.6%] vs 7 [1.1%]), hs-TNI (38 [48.1%] vs 6 [1.0%]), α- HBDH (55 [10.4%] vs 2 [0.2%]), CK-MB (45 [36.3%] vs 12 [0.9%]), and LDH (56 [12.5%] vs 1 [0.1%]) had a significantly higher mortality rate compared to patients with normal levels. The same trend was observed in the ICU admission rate. Severe/critical COVID-19 patients with pre-existing coronary artery disease (165/1,155 [10.9%]) had more cases of BNP (52 [46.5%] vs 119 [16.5%]), hs-TNI (24 [26.7%] vs 9.6 [%], α- HBDH (86 [55.5%] vs 443 [34.4%]), CK-MB (27 [17.4%] vs 97 [7.5%]), and LDH (65 [41.9%] vs 382 [29.7%]), when compared with those without coronary artery disease. There was enhanced SARS-CoV-2 receptor expression in coronary artery disease compared with healthy controls. From regression analysis, patients with five elevated cardiac markers were at a higher risk of death (hazards ratio 3.4 [95% CI 2.4–4.8]). Conclusions COVID-19 patients with pre-existing coronary artery disease represented a higher abnormal percentage of cardiac markers, accompanied by high mortality and ICU admission rate. BNP together with hs-TNI, α- HBDH, CK-MB and LDH act as a prognostic biomarker in COVID-19 patients with or without pre-existing coronary artery disease.

scholarly journals Evaluation of Immuno-Rolling Circle Amplification for Multiplex Detection and Profiling of Antigen-Specific Antibody Isotypes

2021 ◽  
Vol 93 (15) ◽  
pp. 6169-6177
Author(s):  
Sara Horta ◽  
Felix Neumann ◽  
Shu-hao Yeh ◽  
Christoffer Mattsson Langseth ◽  
Kadri Kangro ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Rolling Circle Amplification ◽  
Multiplex Detection ◽  
Rolling Circle ◽  
Antibody Isotypes
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