Designing Recognition Molecules and Tailoring Functional Surfaces for In Vivo Monitoring of Small Molecules in the Brain

2018 ◽  
Vol 51 (3) ◽  
pp. 688-696 ◽  
Author(s):  
Limin Zhang ◽  
Yang Tian
Keyword(s):  
Small Molecules ◽  
In Vivo Monitoring ◽  
Functional Surfaces ◽  
The Brain

In vivo monitoring of extracellular glutamate in the brain with a microsensor

2006 ◽  
Vol 1118 (1) ◽  
pp. 34-42 ◽  
Author(s):  
W.H. Oldenziel ◽  
G. Dijkstra ◽  
T.I.F.H. Cremers ◽  
B.H.C. Westerink
Keyword(s):  
Extracellular Glutamate ◽  
In Vivo Monitoring ◽  
The Brain

Dual real-time in vivo monitoring system of the brain-gut axis

2020 ◽  
Vol 524 (2) ◽  
pp. 340-345 ◽  
Author(s):  
Yuya Nishimura ◽  
Yota Fukuda ◽  
Toya Okonogi ◽  
Soichiro Yoshikawa ◽  
Hajime Karasuyama ◽  
...  
Keyword(s):  
Real Time ◽  
Monitoring System ◽  
In Vivo Monitoring ◽  
The Brain

In vivo near-infrared and Cerenkov luminescence imaging of amyloid-β deposits in the brain: a fluorinated small molecule used for dual-modality imaging

2016 ◽  
Vol 52 (86) ◽  
pp. 12745-12748 ◽  
Author(s):  
Hualong Fu ◽  
Cheng Peng ◽  
Zhigang Liang ◽  
Jiapei Dai ◽  
Boli Liu ◽  
...  
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Near Infrared ◽  
Amyloid Β ◽  
Dual Modality ◽  
Luminescence Imaging ◽  
Cerenkov Luminescence Imaging ◽  
Dual Modality Imaging ◽  
The Brain

Three fluorinated (19F or 18F) small molecules were evaluated as fluorescent or radiolabeled probes for Aβ deposits in the brain.

scholarly journals Development of a novel micro biosensor for in vivo monitoring of glutamate release in the brain

2019 ◽  
Vol 130 ◽  
pp. 103-109 ◽  
Author(s):  
Mallikarjunarao Ganesana ◽  
Elefterios Trikantzopoulos ◽  
Yash Maniar ◽  
Scott T. Lee ◽  
B. Jill Venton
Keyword(s):  
Glutamate Release ◽  
In Vivo Monitoring ◽  
The Brain

scholarly journals The Anti-Epileptic Effects of Carbenoxolone In Vitro and In Vivo

2022 ◽  
Vol 23 (2) ◽  
pp. 663
Author(s):  
Anna Volnova ◽  
Vassiliy Tsytsarev ◽  
Olga Ganina ◽  
Grace E. Vélez-Crespo ◽  
Janaina M. Alves ◽  
...  
Keyword(s):  
Small Molecules ◽  
Intercellular Junctions ◽  
Epileptic Seizures ◽  
Selective Inhibition ◽  
Epileptic Activity ◽  
Seizure Onset ◽  
Neuronal Synchronization ◽  
The Brain

Gap junctions (GJs) are intercellular junctions that allow the direct transfer of ions and small molecules between neighboring cells, and GJs between astrocytes play an important role in the development of various pathologies of the brain, including regulation of the pathological neuronal synchronization underlying epileptic seizures. Recently, we found that a pathological change is observed in astrocytes during the ictal and interictal phases of 4-aminopyridin (4-AP)-elicited epileptic activity in vitro, which was correlated with neuronal synchronization and extracellular epileptic electrical activity. This finding raises the question: Does this signal depend on GJs between astrocytes? In this study we investigated the effect of the GJ blocker, carbenoxolone (CBX), on epileptic activity in vitro and in vivo. Based on the results obtained, we came to the conclusion that the astrocytic syncytium formed by GJ-associated astrocytes, which is responsible for the regulation of potassium, affects the formation of epileptic activity in astrocytes in vitro and epileptic seizure onset. This effect is probably an important, but not the only, mechanism by which CBX suppresses epileptic activity. It is likely that the mechanisms of selective inhibition of GJs between astrocytes will show important translational benefits in anti-epileptic therapies.

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