Development of an Efficient Biosensor for the In Vivo Monitoring of Cu+ and pH in the Brain: Rational Design and Synthesis of Recognition Molecules

2017 ◽  
Vol 129 (51) ◽  
pp. 16546-16550 ◽  
Author(s):  
Wei Liu ◽  
Hui Dong ◽  
Limin Zhang ◽  
Yang Tian
Keyword(s):  
Rational Design ◽  
In Vivo Monitoring ◽  
Design And Synthesis ◽  
The Brain

scholarly journals The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses

2021 ◽  
Vol 12 ◽  
Author(s):  
Luping Zhang ◽  
Dengyuan Zhou ◽  
Qiuyan Li ◽  
Shuo Zhu ◽  
Muhammad Imran ◽  
...  
Keyword(s):  
Antiviral Effect ◽  
Therapeutic Drug ◽  
Dependent Manner ◽  
Design And Synthesis ◽  
Invasion Stage ◽  
Synthetic Derivatives ◽  
Dose Dependent ◽  
The Brain

Flaviviruses are the major emerging arthropod-borne pathogens globally. However, there is still no practical anti-flavivirus approach. Therefore, existing and emerging flaviviruses desperately need active broad-spectrum drugs. In the present study, the antiviral effect of steroidal dehydroepiandrosterone (DHEA) and 23 synthetic derivatives against flaviviruses such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), and Dengue virus (DENV) were appraised by examining the characteristics of virus infection both in vitro and in vivo. Our results revealed that AV1003, AV1004 and AV1017 were the most potent inhibitors of flavivirus propagation in cells. They mainly suppress the viral infection in the post-invasion stage in a dose-dependent manner. Furthermore, orally administered compound AV1004 protected mice from lethal JEV infection by increasing the survival rate and reducing the viral load in the brain of infected mice. These results indicate that the compound AV1004 might be a potential therapeutic drug against JEV infection. These DHEA derivatives may provide lead scaffolds for further design and synthesis of potential anti-flavivirus potential drugs.

In vivo monitoring of extracellular glutamate in the brain with a microsensor

2006 ◽  
Vol 1118 (1) ◽  
pp. 34-42 ◽  
Author(s):  
W.H. Oldenziel ◽  
G. Dijkstra ◽  
T.I.F.H. Cremers ◽  
B.H.C. Westerink
Keyword(s):  
Extracellular Glutamate ◽  
In Vivo Monitoring ◽  
The Brain

Dual real-time in vivo monitoring system of the brain-gut axis

2020 ◽  
Vol 524 (2) ◽  
pp. 340-345 ◽  
Author(s):  
Yuya Nishimura ◽  
Yota Fukuda ◽  
Toya Okonogi ◽  
Soichiro Yoshikawa ◽  
Hajime Karasuyama ◽  
...  
Keyword(s):  
Real Time ◽  
Monitoring System ◽  
In Vivo Monitoring ◽  
The Brain

Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio distribution studies

2018 ◽  
Vol 81 ◽  
pp. 481-493 ◽  
Author(s):  
Somaia S. Abd El-Karim ◽  
Manal M. Anwar ◽  
Yasmin M. Syam ◽  
Manal A. Nael ◽  
Hanan F. Ali ◽  
...  
Keyword(s):  
Rational Design ◽  
3D Qsar ◽  
Design And Synthesis ◽  
Distribution Studies

scholarly journals Development of a novel micro biosensor for in vivo monitoring of glutamate release in the brain

2019 ◽  
Vol 130 ◽  
pp. 103-109 ◽  
Author(s):  
Mallikarjunarao Ganesana ◽  
Elefterios Trikantzopoulos ◽  
Yash Maniar ◽  
Scott T. Lee ◽  
B. Jill Venton
Keyword(s):  
Glutamate Release ◽  
In Vivo Monitoring ◽  
The Brain
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