Capillary Electrophoresis ofN-Acetylneuraminic Acid Polymers and Hyaluronic Acid:  Correlation between Migration Order Reversal and Biological Functions

1999 ◽  
Vol 71 (8) ◽  
pp. 1592-1596 ◽  
Author(s):  
Kazuaki Kakehi ◽  
Mitsuhiro Kinoshita ◽  
Shozo Hayase ◽  
Yasuo Oda
Keyword(s):  
Capillary Electrophoresis ◽  
Hyaluronic Acid ◽  
Biological Functions ◽  
Acetylneuraminic Acid

scholarly journals Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

2020 ◽  
Vol 9 (1) ◽  
pp. 1059-1079
Author(s):  
Fei Xing ◽  
Changchun Zhou ◽  
Didi Hui ◽  
Colin Du ◽  
Lina Wu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Wound Repair ◽  
Bone Tissue Regeneration ◽  
Biological Functions ◽  
Bioactive Polymers ◽  
Bioactive Component ◽  
Good Potential ◽  
Processing Properties

AbstractHyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.

Online preconcentration and determination of chondroitin sulfate, dermatan sulfate and hyaluronic acid in biological and cosmetic samples using capillary electrophoresis

2019 ◽  
Vol 42 (17) ◽  
pp. 2867-2874 ◽  
Author(s):  
Kanokporn Chindaphan ◽  
Kanet Wongravee ◽  
Thumnoon Nhujak ◽  
Thasinas Dissayabutra ◽  
Monpichar Srisa‐Art
Keyword(s):  
Capillary Electrophoresis ◽  
Hyaluronic Acid ◽  
Chondroitin Sulfate ◽  
Dermatan Sulfate ◽  
Online Preconcentration

Cartilage: Multiscale Structure and Biomechanical Properties

MRS Advances ◽  
2016 ◽  
Vol 1 (8) ◽  
pp. 509-519
Author(s):  
Ferenc Horkay ◽  
Peter J. Basser ◽  
Anne-Marie Hecht ◽  
Erik Geissler
Keyword(s):  
Hyaluronic Acid ◽  
Small Angle ◽  
Swelling Pressure ◽  
Biomechanical Properties ◽  
Tissue Level ◽  
Biological Functions ◽  
Osmotic Swelling ◽  
X Ray ◽  
X Ray Scattering ◽  
Compressive Resistance

ABSTRACTCartilage is a load bearing tissue that has multiple biological functions. The major proteoglycan in cartilage is the bottlebrush shaped aggrecan whose complexes with hyaluronic acid provide the compressive resistance of cartilage. The negatively charged aggrecan-hyaluronic acid complexes generate an osmotic swelling pressure within the tissue, which is balanced by the collagen network. To better understand the function of cartilage at the tissue level, we study aggrecan assemblies using an array of microscopic and macroscopic techniques. The organization of aggrecan assemblies at the supramolecular level is probed by light scattering, small-angle neutron scattering and small-angle X-ray scattering. Osmotic and rheological measurements are used to investigate the macroscopic physical properties.

scholarly journals Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 931 ◽  
Author(s):  
N.Vijayakameswara Rao ◽  
Jun Gi Rho ◽  
Wooram Um ◽  
Pramod Kumar EK ◽  
Van Quy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Therapeutic Agent ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Biological Functions ◽  
Wide Range ◽  
Diagnostic Agents ◽  
Long Acting

Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

Lactone formation ofN-acetylneuraminic acid oligomers and polymers as examined by capillary electrophoresis

2001 ◽  
Vol 22 (16) ◽  
pp. 3466-3470 ◽  
Author(s):  
Kazuaki Kakehi ◽  
Mitsuhiro Kinoshita ◽  
Kozue Kitano ◽  
Masanori Morita ◽  
Yasuo Oda
Keyword(s):  
Capillary Electrophoresis ◽  
Acetylneuraminic Acid
Sign in / Sign up

Export Citation Format

Share Document