Synthesis and Characterization of New Zirconia-Based Polymeric Cation-Exchange Stationary Phases for High-Performance Liquid Chromatography of Proteins

1998 ◽  
Vol 70 (9) ◽  
pp. 1934-1942 ◽  
Author(s):  
Yue Hu ◽  
Peter W. Carr
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Cation Exchange ◽  
High Performance ◽  
Stationary Phases ◽  
Synthesis And Characterization

scholarly journals Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

2008 ◽  
Vol 5 (3) ◽  
pp. 562-566
Author(s):  
Singamsetty Radha Krishna ◽  
Mandava Venkata Naga Brahmeshwar Rao ◽  
Tirmalaraju Satyanaryana Raju ◽  
Vurimidi Himabindu ◽  
Ghanta Mahesh Reddy
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Mass Number ◽  
Synthesis And Characterization ◽  
Reverse Phase ◽  
Bulk Drug

Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.

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