High-Throughput Pesticide Residue Quantitative Analysis Achieved by Tandem Mass Spectrometry with Automated Flow Injection

2009 ◽  
Vol 81 (8) ◽  
pp. 3134-3142 ◽  
Author(s):  
Sergio C. Nanita ◽  
Anne M. Pentz ◽  
Frederick Q. Bramble
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Tandem Mass Spectrometry ◽  
Pesticide Residue ◽  
High Throughput ◽  
Flow Injection ◽  
Tandem Mass

Ammonium salting out extraction with analyte preconcentration for sub-part per billion quantitative analysis in surface, ground and drinking water by flow injection tandem mass spectrometry

2015 ◽  
Vol 7 (6) ◽  
pp. 2300-2312 ◽  
Author(s):  
Sergio C. Nanita ◽  
Laura G. Kaldon ◽  
David L. Bailey
Keyword(s):  
Mass Spectrometry ◽  
Drinking Water ◽  
Quantitative Analysis ◽  
Tandem Mass Spectrometry ◽  
High Throughput ◽  
Flow Injection ◽  
Tandem Mass ◽  
High Throughput Analysis ◽  
Salting Out ◽  
Analyte Preconcentration

Ammonium salting out provides instantaneous analyte preconcentration for high-throughput analysis of bioactive compounds in water by FIA-MS/MS.

Rapid Quantitative Analysis of Multiple Explosive Compound Classes on a Single Instrument via Flow‐Injection Analysis Tandem Mass Spectrometry

2018 ◽  
Vol 64 (1) ◽  
pp. 223-230 ◽  
Author(s):  
Alla Ostrinskaya ◽  
Roderick R. Kunz ◽  
Michelle Clark ◽  
Richard P. Kingsborough ◽  
Ta‐Hsuan Ong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Tandem Mass Spectrometry ◽  
Flow Injection ◽  
Flow Injection Analysis ◽  
Tandem Mass ◽  
Single Instrument

Accurate high throughput quantification of selenium in biological samples – the potential of combining isotope dilution ICP-tandem mass spectrometry with flow injection

2016 ◽  
Vol 31 (11) ◽  
pp. 2227-2232 ◽  
Author(s):  
Luca Bamonti ◽  
Sarah Theiner ◽  
Nataliya Rohr-Udilova ◽  
Bernhard K. Keppler ◽  
Gunda Koellensperger
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Human Serum ◽  
High Throughput ◽  
Flow Injection ◽  
Isotope Dilution ◽  
Biological Samples ◽  
Tandem Mass ◽  
Icp Ms

Different strategies for the analysis of selenium in human serum were validated by tandem ICP-MS and isotope dilution.

scholarly journals Analytical Evaluation of the Ideal Strategy for High-Throughput Flow Injection Analysis by Tandem Mass Spectrometry in Routine Newborn Screening

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 473
Author(s):  
Ilaria Cicalini ◽  
Silvia Valentinuzzi ◽  
Damiana Pieragostino ◽  
Ada Consalvo ◽  
Mirco Zucchelli ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Newborn Screening ◽  
High Throughput ◽  
Flow Injection ◽  
Tandem Mass ◽  
Fully Integrated ◽  
System A ◽  
Sample Extract ◽  
Expanded Newborn Screening

The introduction of tandem mass spectrometry (MS/MS) to clinical laboratories and the advent of expanded newborn screening (NBS) were crucial changes to public health programs worldwide. Speed, robustness, accuracy, selectivity, and specificity of analysis are all requirements of expanded NBS and are needed to minimize false positive results risks, to possibly eliminate false negatives, and to improve the positive predictive value of NBS. In this study, we firstly evaluated the analytical performances of the RenataDX Screening System, a fully integrated flow-injection MS/MS (FIA-MS/MS) IVD system for high-throughput dried blood spot (DBS) analysis in a routine NBS laboratory. Since a choice of several commercial NBS kits is available, we sought to compare NeoBaseTM 2 (PerkinElmer®) and MassChrom® (Chromsystems) non-derivatized kits on the RenataDX platform by evaluating their analytical performances. Moreover, we verified the degree of correlation between data obtained by the two different NBS MS/MS kits by FIA-MS/MS of over 500 samples. Our data suggest that both methods correlate well with clinically insignificant differences that do not impact the NBS result. Finally, while NeoBase™ 2 offers an easier and faster sample preparation, MassChrom® provides a cleaner sample extract which empirically should improve instrument reliability.

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