Broad-Specific Antibodies for a Generic Immunoassay of Quinolone: Development of a Molecular Model for Selection of Haptens Based on Molecular Field-Overlapping

2009 ◽  
Vol 81 (9) ◽  
pp. 3246-3251 ◽  
Author(s):  
Limin Cao ◽  
Dexin Kong ◽  
Jianxin Sui ◽  
Tao Jiang ◽  
Zongyan Li ◽  
...  

The investigation of a preceding paper has shown that the temperature variation of viscosity, as determined experimentally, can be satisfactorily explained in many gases on the assumption that the repulsive and attractive parts of the molecular field are each according to an inverse power of the distance. In some cases, in argon, for example, it was further shown that the experimental facts can be explained by more than one molecular model, from which we inferred that viscosity results alone are insufficient to determine precisely the nature of molecular fields. The object of the present paper is to ascertain whether a molecular model of the same type will also explain available experimental data concerning the equation of state of a gas, and if so, whether the results so obtained, when taken in conjunction with those obtained from viscosity, will definitely fix the molecular field. Such an investigation is made possible by the elaborate analysis by Kamerlingh Onnes of the observational material. He has expressed the results in the form of an empirical equation of state of the type pv = A + B/ v + C/ v 2 + D/ v 4 + E/ v 6 + F/ v 8 , where the coefficients A ... F, called by him virial coefficients , are determined as functions of the temperature to fit the observations. Now it is possible by various methods to obtain a theoretical expression for B as a function of the temperature and a strict comparison can then be made between theory and experiment. Unfortunately the solution for B, although applicable to any molecular model of spherical symmetry, is purely formal and contains an integral which can be evaluated only in special cases. This has been done up to now for only two simple models, viz., a van der Waals molecule, and a molecule repelling according to an inverse power law (without attraction), but it is shown in this paper that it can also be evaluated in the case of the model, which was successful in explaining viscosity results. As the two other models just mentioned are particular cases of this, the appropriate formulæ for B are easily deduced from the general one given here.


2010 ◽  
Vol 353 (1-2) ◽  
pp. 24-30 ◽  
Author(s):  
Helena Persson ◽  
Jonas Persson ◽  
Lena Danielsson ◽  
Mats Ohlin

Author(s):  
Santoso Santoso ◽  
Sri Cahyaningrum

Agam District finished the repetition of Filariasis treatment for 2 years, so Agam must be conducting the Re-TAS. Re-TAS was conducted on elementary school students grade 1 and 2 in the district of Agam. Survey design using the school cluster. The number of schools selected were 40 schools. Selection of the sample schools were calculated using sample survey builder (SSB). All students grades 1 and 2 in selected schools were examined using Brugia Rapid test to assess the presence of specific antibodies against Brugia malayi and B. timori worms. The  number of students who registered as many as 1,999 children, while being examined by RDT as many as 1,717. A total of 282 students were absent during the examination or refused to be examined.Test results showed that 3 positive, 1694 negative, 20 invalid and 3 samples were excluded. The number of samples taken into account to assess the transmission of filariasis as many as 1,697, which is only positive and negative samples. The survey found that the minimum sample was adequate and the number of positive children under the cut off point, so Agam passed TAS 1.


2006 ◽  
Vol 24 (6) ◽  
pp. 703-707 ◽  
Author(s):  
J Christopher Love ◽  
Jehnna L Ronan ◽  
Gijsbert M Grotenbreg ◽  
Annemarthe G van der Veen ◽  
Hidde L Ploegh

2018 ◽  
Vol 74 (8) ◽  
pp. 517-519
Author(s):  
WIKTOR BOJAR ◽  
ANDRZEJ JUNKUSZEW ◽  
MONIKA OLECH ◽  
JACEK KUŹMAK ◽  
KLAUDIUSZ SZCZEPANIAK

The aim of the study was to determine the prevalence of SRLV infection in sheep breeds farmed in mid-Eastern Poland. Out of 6,470 mother ewes kept in 98 nucleus flocks of various sizes, 2,924 belonging to 15 breeds and lines were selected for serum sample collection. The selection of the animals analyzed was carried out using stratification which enabled the determination of infection prevalence with an error margin no greater than 8%. The assay of SRLV-specific antibodies in blood serum was performed using the ELISA test. The analyses revealed a large diversity of prevalence between the sheep breeds studied. The lowest prevalence was observed in Uhruska sheep, in which only 5.07% had a positive serological reaction, despite the fact that the number of animals of this breed included in the analysis was large (1675 mother ewes). The prevalence for this variety was over 5-7 times lower in comparison to Wielkopolska sheep (35%), Polish Pogorze sheep (22.73%), Podhale Zackel sheep (29.03%) and over 10 times lower than Świniarka sheep (57.04%). The results should be used for developing breeding strategies and establishing anti-SRLV programs..


2015 ◽  
Vol 19 (8) ◽  
pp. 1939-1948 ◽  
Author(s):  
Simon Asbjørn Larsen ◽  
Theresa Meldgaard ◽  
Simon Lykkemark ◽  
Ole Aalund Mandrup ◽  
Peter Kristensen

Sign in / Sign up

Export Citation Format

Share Document