Towards Absolute Quantification of Therapeutic Monoclonal Antibody in Serum by LC−MS/MS Using Isotope-Labeled Antibody Standard and Protein Cleavage Isotope Dilution Mass Spectrometry

2008 ◽  
Vol 80 (11) ◽  
pp. 4200-4207 ◽  
Author(s):  
Olivier Heudi ◽  
Samuel Barteau ◽  
Dieter Zimmer ◽  
Joerg Schmidt ◽  
Kurt Bill ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Absolute Quantification ◽  
Protein Cleavage ◽  
Therapeutic Monoclonal Antibody

Comprehensive Quantification of Monolignol-Pathway Enzymes inPopulus trichocarpaby Protein Cleavage Isotope Dilution Mass Spectrometry

2012 ◽  
Vol 11 (6) ◽  
pp. 3390-3404 ◽  
Author(s):  
Christopher M. Shuford ◽  
Quanzi Li ◽  
Ying-Hsuan Sun ◽  
Hsi-Chuan Chen ◽  
Jack Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Protein Cleavage

scholarly journals Establishing ion ratio thresholds based on absolute peak area for absolute protein quantification using protein cleavage isotope dilution mass spectrometry

The Analyst ◽  
2014 ◽  
Vol 139 (21) ◽  
pp. 5439-5450 ◽  
Author(s):  
Philip L. Loziuk ◽  
Ronald R. Sederoff ◽  
Vincent L. Chiang ◽  
David C. Muddiman
Keyword(s):  
Mass Spectrometry ◽  
Relative Abundance ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Protein Quantification ◽  
Protein Cleavage ◽  
Absolute Abundance

Relative abundance values and their associated variability are dynamic and dependent on absolute abundance.

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