Chromatographic Separation and Determination of Straight-Chain Saturated Monocarboxylic Acids C1through C10and Dicarboxylic Acids C11through C16

1956 ◽  
Vol 28 (2) ◽  
pp. 168-171 ◽  
Author(s):  
G. B. Corcoran
Keyword(s):  
Chromatographic Separation ◽  
Dicarboxylic Acids ◽  
Straight Chain ◽  
Monocarboxylic Acids

Chromatographic Separation and Determination of Dicarboxylic Acids C4to C10

1952 ◽  
Vol 24 (3) ◽  
pp. 491-493 ◽  
Author(s):  
Takeru Higuchi ◽  
N. C. Hill ◽  
G. B. Corcoran
Keyword(s):  
Chromatographic Separation ◽  
Dicarboxylic Acids

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: IV. THE ESTERS OF ACIDS CLOSELY RELATED TO 10-HYDROXY- 2-DECENOIC ACID FROM ROYAL JELLY AGAINST TRANSPLANTABLE MOUSE LEUKEMIA

1961 ◽  
Vol 39 (11) ◽  
pp. 1765-1770 ◽  
Author(s):  
Gordon F. Townsend ◽  
William H. Brown ◽  
Ethel E. Felauer ◽  
Barbara Hazlett
Keyword(s):  
Fatty Acids ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Leukemic Cells ◽  
Straight Chain ◽  
Decenoic Acid ◽  
Monocarboxylic Acids ◽  
Mouse Leukemia ◽  
Related Compounds

Previous studies have shown that whole royal jelly, a fraction from royal jelly (10-hydroxy-2-decenoic acid), and certain closely related dicarboxylic acids, some of which are also found in royal jelly, will inhibit the development of transplantable AKR leukemia when the pH is below 5.6.The ester of 10-hydroxy-2-decenoic acid from royal jelly was found to be just as effective against AKR leukemic cells as the acid itself, with the added advantage that it could be used at neutrality.Through the testing of a series of mono- and di-carboxylic acids, as well as other closely related compounds, the activity has been shown to be associated mainly with 9- and 10-carbon straight chain monocarboxylic acids either saturated or unsaturated. Slight variations in the structure either reduce or destroy the activity.

DETERMINATION OF MICRO-AMOUNTS OF 5β-PREGNAN-3α-OL-20-ONE IN URINE USING INFRARED-SPECTROMETRY

1962 ◽  
Vol 41 (2) ◽  
pp. 234-246 ◽  
Author(s):  
H. J. van der Molen
Keyword(s):  
Infrared Spectrum ◽  
Quantitative Determination ◽  
Acid Hydrolysis ◽  
Chromatographic Separation ◽  
Pure Form ◽  
Infrared Spectrometry ◽  
Hydrolysis Of

ABSTRACT A procedure for the quantitative determination of 5β-pregnan-3α-ol-20-one in urine is described. After acid hydrolysis of the pregnanolone-conjugates in urine, the free steroids are extracted with toluene. Pregnanolone is isolated in a pure form as its acetate; after chromatographic separation of the free steroids on alumina, the fraction containing pregnanolone is acetylated and rechromatographed on alumina. Quantitative determination of the isolated pregnanolone-acetate is carried out with the aid of the infrared spectrum recorded by a micro KBr-wafermethod. The reliability of the method under various conditions is discussed under the headings, specificity, accuracy, precision and sensitivity. It is possible to determine 30–40 μg pregnanolone in a 24-hours urine portion with a precision of 25%.

INFLUENCE OF DICARBOXYLIC ACIDS ON SOWING QUALITY OF SPRING BARLEY

1970 ◽  
pp. 22-25
Author(s):  
N. N. Loy ◽  
S. N. Gulina
Keyword(s):  
Organic Acids ◽  
Spring Barley ◽  
Dose Range ◽  
Dicarboxylic Acids ◽  
Rotary Machine ◽  
Working Solution ◽  
Negative Effect ◽  
Sprouted Seeds

The effect of presowing seed treatment on various concentrations of dicarboxylic (organic) acids on the sowing characteristics of spring barley has been studied. Seeds were treated with organic acids obtained by exposing cuttings to the radiation with a dose of 100 kGy and consequent hydrolysis, in concentrations: 1•10-7 %; 1•10-9; 1•10-11; 1•10-13 and 1•10-15 % on a laboratory rotary machine RVO-64 for one day before laying for germination. Distilled water was used for the control case. The rate of application of the working solution calculated as 10 liters / ton of seeds. Seeds were germinated in filter paper rolls in accordance with GOST 12038-84 requirements. The temperature was maintained at +24 ° C in the thermostat where the glasses with rolls were placed. For determination of germinative power and laboratory germination the sprouted seeds were evaluated after three and seven days, respectively. In laboratory experiments it was established that the treatment of barley seeds of varieties Zazersky 85, Nur and Vladimir with organic acids (OK) in different concentrations had both a stimulating and a negative effect. On the Zazersky 85 variety, in variants with acid concentrations of 1•10-9 and 1•10-11, an increase in germination energy (EP) by 2-4% and a significant decrease (by 3-4%) of laboratory germination (LV) of barley seeds were noted. On the Nur variety, the increase in EP was observed at 4% (concentration 1•10-11), LV and seed growth force (CPC) by 2-7% at a concentration of 1•10-7 and in the dose range 1•10-11 - 1•10-14 compared to the control values. On the grade of Vladimir, an increase in EP, LV, and CPC was found to increase by 1-6% at concentrations OK 1•10-7 and 1•10-13. It was shown that the treatment of seeds with acids led to an increase in the length of the germ in all studied varieties (by 3-9%) and dry biomass of 7-day-old seedlings - by 3-6%. Consequently, the treatment of seeds with a mixture of dicarboxylic acids has a stimulating effect on the sowing quality of spring barley.

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