Ultrafast Microfluidic Mixer for Tracking the Early Folding Kinetics of Human Telomere G-Quadruplex

2014 ◽  
Vol 86 (9) ◽  
pp. 4333-4339 ◽  
Author(s):  
Ying Li ◽  
Chao Liu ◽  
Xiaojun Feng ◽  
Youzhi Xu ◽  
Bi-Feng Liu
Keyword(s):  
Folding Kinetics ◽  
Microfluidic Mixer ◽  
G Quadruplex ◽  
Human Telomere ◽  
Kinetics Of

scholarly journals Folding Kinetics of Multiple G-Quadruplex Telomeric DNA Structures

2020 ◽  
Vol 118 (3) ◽  
pp. 335a
Author(s):  
Emil L. Kristoffersen ◽  
Andrea Coletta ◽  
Line Lund ◽  
Birgit Schiøtt ◽  
Victoria Birkedal
Keyword(s):  
Folding Kinetics ◽  
Telomeric Dna ◽  
Dna Structures ◽  
G Quadruplex ◽  
Kinetics Of

scholarly journals Folding Kinetics of G-Quadruplexes: Duplex Stem Loops Drive and Accelerate G-Quadruplex Folding

2020 ◽  
Vol 124 (25) ◽  
pp. 5122-5130 ◽  
Author(s):  
Thi Quynh Ngoc Nguyen ◽  
Kah Wai Lim ◽  
Anh Tuân Phan
Keyword(s):  
Folding Kinetics ◽  
G Quadruplex ◽  
Kinetics Of

Domain-Specific Folding Kinetics of Staphylococcal Nuclease Observed through Single-Molecule FRET in a Microfluidic Mixer

ChemPhysChem ◽  
2011 ◽  
Vol 12 (18) ◽  
pp. 3515-3518 ◽  
Author(s):  
Zeyong Zhi ◽  
Pengcheng Liu ◽  
Peng Wang ◽  
Yanyi Huang ◽  
Xin Sheng Zhao
Keyword(s):  
Single Molecule ◽  
Staphylococcal Nuclease ◽  
Folding Kinetics ◽  
Microfluidic Mixer ◽  
Domain Specific ◽  
Single Molecule Fret ◽  
Kinetics Of

scholarly journals Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin

ACS Omega ◽  
2016 ◽  
Vol 1 (2) ◽  
pp. 244-250 ◽  
Author(s):  
Hai-Peng Ju ◽  
Yi-Zhou Wang ◽  
Jing You ◽  
Xi-Miao Hou ◽  
Xu-Guang Xi ◽  
...  
Keyword(s):  
Folding Kinetics ◽  
G Quadruplex ◽  
Kinetics Of

scholarly journals Effects of monovalent cations on folding kinetics of G-quadruplexes

2017 ◽  
Vol 37 (4) ◽  
Author(s):  
Jing You ◽  
Hui Li ◽  
Xi-Ming Lu ◽  
Wei Li ◽  
Peng-Ye Wang ◽  
...  
Keyword(s):  
Kinetic Parameters ◽  
Genome Stability ◽  
Structural Transition ◽  
Monovalent Cation ◽  
Monovalent Cations ◽  
Folding Kinetics ◽  
Folding Rates ◽  
Type K ◽  
G Quadruplex ◽  
Kinetics Of

G-quadruplexes are special structures existing at the ends of human telomeres, the folding kinetics of which are essential for their functions, such as in the maintenance of genome stability and the protection of chromosome ends. In the present study, we investigated the folding kinetics of G-quadruplex in different monovalent cation environments and determined the detailed kinetic parameters for Na+- and K+-induced G-quadruplex folding, and for its structural transition from the basket-type Na+ form to the hybrid-type K+ form. More interestingly, although Li+ was often used in previous studies of G-quadruplex folding as a control ion supposed to have no effect, we have found that Li+ can actually influence the folding kinetics of both Na+- and K+-induced G-quadruplexes significantly and in different ways, by changing the folding fraction of Na+-induced G-quadruplexes and greatly increasing the folding rates of K+-induced G-quadruplexes. The present study may shed new light on the roles of monovalent cations in G-quadruplex folding and should be useful for further studies of the underlying folding mechanism.

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