scholarly journals Amino Acid Bound Surfactants: A New Synthetic Family of Polymeric Monoliths Opening Up Possibilities for Chiral Separations in Capillary Electrochromatography

2012 ◽  
Vol 84 (12) ◽  
pp. 5236-5242 ◽  
Author(s):  
Jun He ◽  
Xiaochun Wang ◽  
Mike Morill ◽  
Shahab A. Shamsi
Keyword(s):  
Amino Acid ◽  
Capillary Electrochromatography ◽  
Chiral Separations ◽  
Opening Up

Amino Acid Ionic Liquids as Chiral Ligands in Ligand-Exchange Chiral Separations

2009 ◽  
Vol 15 (38) ◽  
pp. 9889-9896 ◽  
Author(s):  
Qian Liu ◽  
Kangkang Wu ◽  
Fei Tang ◽  
Lihua Yao ◽  
Fei Yang ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Amino Acid ◽  
Ligand Exchange ◽  
Chiral Separations ◽  
Chiral Ligands

Chiral Separations Using Dipeptide Polymerized Surfactants:  Effect of Amino Acid Order

1998 ◽  
Vol 70 (7) ◽  
pp. 1375-1381 ◽  
Author(s):  
Eugene Billiot ◽  
Javier Macossay ◽  
Stefan Thibodeaux ◽  
Shahab A. Shamsi ◽  
Isiah M. Warner
Keyword(s):  
Amino Acid ◽  
Chiral Separations

Analytical and Preparative Scale Separation of Enantiomers of Chiral Drugs by Chromatography and Related Methods

2018 ◽  
Vol 25 (33) ◽  
pp. 4152-4188 ◽  
Author(s):  
Mehmet Gumustas ◽  
Sibel A. Ozkan ◽  
Bezhan Chankvetadze
Keyword(s):  
Capillary Electrochromatography ◽  
High Performance ◽  
Analytical Techniques ◽  
Chiral Separations ◽  
Chiral Drugs ◽  
Preparative Scale ◽  
Enantiomerically Pure ◽  
Separation Of Enantiomers ◽  
Chiral Compounds ◽  
Chiral Pharmaceuticals

While the amino acids, enzymes and hormones are chiral, chirality plays significant role in the life of plants, animals, as well as the human being. Chirality of molecules is important in various industries, such as pharmaceutical, agricultural, food, electronics, etc. Chiral drugs may have different bioavailability, distribution, biotransformation and excretion, as well as quantitatively and/or qualitatively different pharmacological or toxic properties. Enantiomerically pure chiral drugs have been increasingly developed for the pharmaceutical market due to their superiority from the viewpoints of potency and safety. This is supported by the development of new methods for enantioselective production of the chiral compounds, as well as by the capability of the enantioselective analytical methods to allow a detection and quantification of minor enantiomeric impurity in the presence of another enantiomer in a large excess. The aim of the present review is to provide a short summary of the basic principles of chiral separations on an analytical and preparative scale. In addition, some selected applications for analytical techniques, such as gas chromatography, supercritical fluid chromatography, high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography for the separation of enantiomers of chiral pharmaceuticals published in the last two years are also discussed.

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